The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays
Abstract
We describe the design, fabrication and use of a single-layered poly(dimethylsiloxane) microfluidic structure for the entrapment and release of microdroplets in an array format controlled entirely by liquid flow. Aqueous picoliter droplets are trapped en masse and optically monitored for extended periods of time. Such an array-based approach is used to characterize droplet shrinkage, aggregation of encapsulated E. coli cells and enzymatic reactions. We also demonstrate that trapped droplets may be recovered from the microfluidic array for further processing.
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Cites
Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents
Song, H., & Ismagilov, R. F. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0354566 · Cited by 693
Cited by
Single-cell analysis tools for drug discovery and development
Heath, J. R., Ribas, A., & Mischel, P. S. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.16 · Cited by 473
Droplet microfluidics: recent developments and future applications
Casadevall i Solvas, X., & deMello, A. (2011) · Chem. Commun. · doi:10.1039/c0cc02474k · Cited by 353
Self-citationDevelopment and future of droplet microfluidics
Nan, L., Zhang, H., Weitz, D. A., & Shum, H. C. (2024) · Lab on a Chip · doi:10.1039/d3lc00729d · Cited by 253
Concentration gradient generation methods based on microfluidic systems
Wang, X., Liu, Z., & Pang, Y. (2017) · RSC Advances · doi:10.1039/c7ra04494a · Cited by 219
Metadata
- Authors
- Huebner, A., Bratton, D., Whyte, G., Yang, M., deMello, A. J., Abell, C., & Hollfelder, F.
- Venue
- Lab Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 9
- Issue
- 5
- Pages
- 692-698
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W1967179899
- Cited by
- 346
- References
- 1
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- closed
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- Huebner, A., Bratton, D., Whyte, G., Yang, M., deMello, A. J., Abell, C., & Hollfelder, F. (2009). Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays. Lab Chip. https://doi.org/10.1039/b813709a
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
