Concentration gradient generation methods based on microfluidic systems

Chaotic Mixer for Microchannels

Stroock, A. D., Dertinger, S. K. W., Ajdari, A., Mezić, I., Stone, H. A., & Whitesides, G. M. (2002) · Science · doi:10.1126/science.1066238 · Cited by 3,435 · see citing works

The present and future role of microfluidics in biomedical research

Sackmann, E. K., Fulton, A. L., & Beebe, D. J. (2014) · Nature · doi:10.1038/nature13118 · Cited by 2,995 · see citing works

Control and detection of chemical reactions in microfluidic systems

deMello, A. J. (2006) · Nature · doi:10.1038/nature05062 · Cited by 1,498 · see citing works

Biology's new dimension

Abbott, A. (2003) · Nature · doi:10.1038/424870a · Cited by 1,237 · see citing works

Dynamics of microfluidic droplets

Baroud, C. N., Gallaire, F., & Dangla, R. (2010) · Lab on a Chip · doi:10.1039/c001191f · Cited by 1,081 · see citing works

Droplet microfluidic technology for single-cell high-throughput screening

Brouzes, E., Medkova, M., Savenelli, N., Marran, D., Twardowski, M., Hutchison, J. B., Rothberg, J., Link, D., Perrimon, N., & Samuels, M. (2009) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.0903542106 · Cited by 1,064 · see citing works

Generation of Solution and Surface Gradients Using Microfluidic Systems

Jeon, N. L., Dertinger, S. K. W., Chiu, D. T., Choi, I. S., Stroock, A. D., & Whitesides, G. M. (2000) · Langmuir · doi:10.1021/la000600b · Cited by 965 · see citing works

Cold Spring Harbor Perspectives in BiologyPreprint

(2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect_biol/ · Cited by 949 · see citing works

Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device

Jeon, N. L., Baskaran, H., Dertinger, S. K. W., Whitesides, G. M., Water, L. V. D., & Toner, M. (2002) · Nature Biotechnology · doi:10.1038/nbt712 · Cited by 918 · see citing works

Generation of Gradients Having Complex Shapes Using Microfluidic Networks

Dertinger, S. K. W., Chiu, D. T., Jeon, N. L., & Whitesides, G. M. (2001) · Analytical Chemistry · doi:10.1021/ac001132d · Cited by 842 · see citing works

Millisecond Kinetics on a Microfluidic Chip Using Nanoliters of Reagents

Song, H., & Ismagilov, R. F. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0354566 · Cited by 693 · see citing works

Design of pressure-driven microfluidic networks using electric circuit analogy

Oh, K. W., Lee, K., Ahn, B., & Furlani, E. P. (2011) · Lab on a Chip · doi:10.1039/c2lc20799k · Cited by 685 · see citing works

Microfabrication Inside Capillaries Using Multiphase Laminar Flow Patterning

Kenis, P. J. A., Ismagilov, R. F., & Whitesides, G. M. (1999) · Science · doi:10.1126/science.285.5424.83 · Cited by 660 · see citing works

Droplet formation in a microchannel network

Nisisako, T., Torii, T., & Higuchi, T. (2002) · Lab on a Chip · doi:10.1039/b108740c · Cited by 610 · see citing works

Biomolecular gradients in cell culture systems

Keenan, T. M., & Folch, A. (2008) · Lab Chip · doi:10.1039/b711887b · Cited by 596 · see citing works

Human neural stem cell growth and differentiation in a gradient-generating microfluidic device

Chung, B. G., Flanagan, L. A., Rhee, S. W., Schwartz, P. H., Lee, A. P., Monuki, E. S., & Jeon, N. L. (2005) · Lab on a Chip · doi:10.1039/b417651k · Cited by 558 · see citing works

Experimental and theoretical scaling laws for transverse diffusive broadening in two-phase laminar flows in microchannels

Ismagilov, R. F., Stroock, A. D., Kenis, P. J. A., Whitesides, G. M., & Stone, H. A. (2000) · Applied Physics Letters · doi:10.1063/1.126351 · Cited by 540 · see citing works

Continuous perfusion microfluidic cell culture array for high‐throughput cell‐based assays

Hung, P. J., Lee, P. J., Sabounchi, P., Lin, R., & Lee, L. P. (2004) · Biotechnology and Bioengineering · doi:10.1002/bit.20289 · Cited by 522 · see citing works

Microfluidic Diffusion-Based Separation and Detection

Weigl, B. H., & Yager, P. (1999) · Science · doi:10.1126/science.283.5400.346 · Cited by 505 · see citing works

Dynamics of Drosophila embryonic patterning network perturbed in space and time using microfluidics

Lucchetta, E. M., Lee, J. H., Fu, L. A., Patel, N. H., & Ismagilov, R. F. (2005) · Nature · doi:10.1038/nature03509 · Cited by 449 · see citing works

Gradients of substrate-bound laminin orient axonal specification of neurons

Dertinger, S. K. W., Jiang, X., Li, Z., Murthy, V. N., & Whitesides, G. M. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192457199 · Cited by 446 · see citing works

A Droplet‐Based, Composite PDMS/Glass Capillary Microfluidic System for Evaluating Protein Crystallization Conditions by Microbatch and Vapor‐Diffusion Methods with On‐Chip X‐Ray Diffraction

Zheng, B., Tice, J. D., Roach, L. S., & Ismagilov, R. F. (2004) · Angewandte Chemie International Edition · doi:10.1002/anie.200453974 · Cited by 399 · see citing works

Microenvironment design considerations for cellular scale studies

Walker, G. M., Zeringue, H. C., & Beebe, D. J. (2004) · Lab on a Chip · doi:10.1039/b311214d · Cited by 387 · see citing works

A rapid diffusion immunoassay in a T-sensor

Hatch, A. V., Kamholz, A. E., Hawkins, K. R., Munson, M. S., Schilling, E. A., Weigl, B. H., & Yager, P. (2001) · Nature Biotechnology · doi:10.1038/88135 · Cited by 383 · see citing works

Pillar-induced droplet merging in microfluidic circuits

Niu, X., Gulati, S., Edel, J. B., & deMello, A. J. (2008) · Lab on a Chip · doi:10.1039/b813325e · Cited by 375 · see citing works

A hydrogel-based microfluidic device for the studies of directed cell migration

Cheng, S.-Y., Heilman, S., Wasserman, M., Archer, S. D., Shuler, M. L., & Wu, M. (2007) · Lab on a Chip · doi:10.1039/b618463d · Cited by 359 · see citing works

Static microdroplet arrays: a microfluidic device for droplet trapping, incubation and release for enzymatic and cell-based assays

Huebner, A., Bratton, D., Whyte, G., Yang, M., deMello, A. J., Abell, C., & Hollfelder, F. (2008) · Lab on a Chip · doi:10.1039/b813709a · Cited by 348 · see citing works

Design, fabrication and implementation of a novel multi-parameter control microfluidic platform for three-dimensional cell culture and real-time imaging

Vickerman, V., Blundo, J. T., Chung, S. H., & Kamm, R. D. (2008) · Lab on a Chip · doi:10.1039/b802395f · Cited by 337 · see citing works

MAPK-mediated bimodal gene expression and adaptive gradient sensing in yeast

Paliwal, S., Iglesias, P. A., Campbell, K., Hilioti, Z., Groisman, A., & Levchenko, A. (2007) · Nature · doi:10.1038/nature05561 · Cited by 291 · see citing works

High-resolution dose–response screening using droplet-based microfluidics

Miller, O. J., Harrak, A. E., Mangeat, T., Baret, J., Frenz, L., Debs, B. E., Mayot, E., Samuels, M. L., Rooney, E. K., Dieu, P., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113324109 · Cited by 285 · see citing works

Droplet microfluidics driven by gradients of confinement

Dangla, R., Kayi, S. C., & Baroud, C. N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209186110 · Cited by 282 · see citing works

Differential effects of EGF gradient profiles on MDA-MB-231 breast cancer cell chemotaxis

Wang, S., Saadi, W. M., Lin, F., Nguyen, C. M.-C., & Jeon, N. L. (2004) · Experimental Cell Research · doi:10.1016/j.yexcr.2004.06.030 · Cited by 277 · see citing works

Effects of flow and diffusion on chemotaxis studies in a microfabricated gradient generator

Walker, G. M., Sai, J., Richmond, A. J., Stremler, M. A., Chung, C. Y., & Wikswo, J. P. (2005) · Lab on a Chip · doi:10.1039/b417245k · Cited by 267 · see citing works

Theoretical Analysis of Molecular Diffusion in Pressure-Driven Laminar Flow in Microfluidic Channels

Kamholz, A. E., & Yager, P. (2001) · Biophysical Journal · doi:10.1016/s0006-3495(01)76003-1 · Cited by 249 · see citing works

Cell-based high content screening using an integrated microfluidic device

Ye, N., Qin, J., Shi, W., Liu, X., & Lin, B. (2007) · Lab on a Chip · doi:10.1039/b711513j · Cited by 246 · see citing works

Characterization of a membrane-based gradient generator for use in cell-signaling studies

Abhyankar, V. V., Lokuta, M. A., Anna Huttenlocher, A., & Beebe, D. J. (2006) · Lab on a Chip · doi:10.1039/b514133h · Cited by 241 · see citing works

A three-channel microfluidic device for generating static linear gradients and its application to the quantitative analysis of bacterial chemotaxis

Diao, J., Young, L., Kim, S., Fogarty, E. A., Heilman, S., Zhou, P., Shuler, M. L., Wu, M., & DeLisa, M. P. (2005) · Lab on a Chip · doi:10.1039/b511958h · Cited by 239 · see citing works

Universal Microfluidic Gradient Generator

Irimia, D., Geba, D. A., & Toner, M. (2006) · Analytical Chemistry · doi:10.1021/ac0518710 · Cited by 234 · see citing works

Picoliter Cell Lysate Assays in Microfluidic Droplet Compartments for Directed Enzyme Evolution

Kintses, B., Hein, C., Mohamed, M. F., Fischlechner, M., Courtois, F., Lainé, C., & Hollfelder, F. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.06.009 · Cited by 233 · see citing works

Rapid screening of antibiotic toxicity in an automated microdroplet system

Churski, K., Kamiński, T. S., Jakieła, S., Kamysz, W., Barańska‐Rybak, W., Weibel, D. B., & Garstecki, P. (2012) · Lab on a Chip · doi:10.1039/c2lc21284f · Cited by 227 · see citing works

Generation of dynamic temporal and spatial concentration gradients using microfluidic devices

Lin, F., Saadi, W. M., Rhee, S. W., Wang, S., Mittal, S., & Jeon, N. L. (2004) · Lab on a Chip · doi:10.1039/b313600k · Cited by 222 · see citing works

Interstitial cell migration: integrin-dependent and alternative adhesion mechanisms

Schmidt, S., & Friedl, P. (2009) · Cell and Tissue Research · doi:10.1007/s00441-009-0892-9 · Cited by 217 · see citing works

Microvalve-actuated precise control of individual droplets in microfluidic devices

Zeng, S., Li, B., Su, X., Qin, J., & Lin, B. (2009) · Lab on a Chip · doi:10.1039/b821803j · Cited by 214 · see citing works

Nanoliter scale microbioreactor array for quantitative cell biology

Lee, P. J., Hung, P. J., Rao, V. M., & Lee, L. P. (2005) · Biotechnology and Bioengineering · doi:10.1002/bit.20745 · Cited by 212 · see citing works

Selective Chemical Treatment of Cellular Microdomains Using Multiple Laminar Streams

Takayama, S., Ostuni, E., LeDuc, P. R., Naruse, K., Ingber, D. E., & Whitesides, G. M. (2003) · Chemistry & Biology · doi:10.1016/s1074-5521(03)00019-x · Cited by 210 · see citing works

Endothelial cell polarization and chemotaxis in a microfluidic device

Shamloo, A., Ma, N., Poo, M., Sohn, L. L., & Heilshorn, S. C. (2008) · Lab on a Chip · doi:10.1039/b719788h · Cited by 209 · see citing works

Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19

Haessler, U., Pisano, M., Wu, M., & Swartz, M. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014920108 · Cited by 207 · see citing works

A parallel-gradient microfluidic chamber for quantitative analysis of breast cancer cell chemotaxis

Saadi, W. M., Wang, S., Lin, F., & Jeon, N. L. (2006) · Biomedical Microdevices · doi:10.1007/s10544-006-7706-6 · Cited by 204 · see citing works

Microfluidic system for measuring neutrophil migratory responses to fast switches of chemical gradients

Irimia, D., Liu, S.-Y., Tharp, W. G., Samadani, A., Toner, M., & Poznansky, M. C. (2005) · Lab on a Chip · doi:10.1039/b511877h · Cited by 196 · see citing works

A microdroplet dilutor for high-throughput screening

Niu, X., Gielen, F., Edel, J. B., & deMello, A. J. (2011) · Nature Chemistry · doi:10.1038/nchem.1046 · Cited by 196 · see citing works

Generation of stable concentration gradients in 2D and 3D environments using a microfluidic ladder chamber

Saadi, W. M., Rhee, S. W., Lin, F., Vahidi, B., Chung, B. G., & Jeon, N. L. (2007) · Biomedical Microdevices · doi:10.1007/s10544-007-9051-9 · Cited by 194 · see citing works

Engineering microfluidic concentration gradient generators for biological applications

Toh, A. G. G., Wang, Z. P., Yang, C., & Nguyen, N. (2013) · Microfluidics and Nanofluidics · doi:10.1007/s10404-013-1236-3 · Cited by 189 · see citing works

Generation of oxygen gradients in microfluidic devices for cell culture using spatially confined chemical reactions

Chen, Y.-A., King, A., Shih, H.-C., Peng, C., Wu, C., Liao, W., & Tung, Y. (2011) · Lab on a Chip · doi:10.1039/c1lc20325h · Cited by 185 · see citing works

An Integrated Device for Monitoring Time‐Dependent in vitro Expression From Single Genes in Picolitre Droplets

Courtois, F., Olguín, L. F., Whyte, G., Bratton, D., Huck, W. T. S., Abell, C., & Hollfelder, F. (2008) · ChemBioChem · doi:10.1002/cbic.200700536 · Cited by 183 · see citing works

An agarose-based microfluidic platform with a gradient buffer for 3D chemotaxis studies

Haessler, U., Kalinin, Y. V., Swartz, M. A., & Wu, M. (2009) · Biomedical Microdevices · doi:10.1007/s10544-009-9299-3 · Cited by 180 · see citing works

A Digital Microfluidic Approach to Homogeneous Enzyme Assays

Miller, E. M., & Wheeler, A. R. (2008) · Analytical Chemistry · doi:10.1021/ac702269d · Cited by 167 · see citing works

Bacterial Chemotaxis in Linear and Nonlinear Steady Microfluidic Gradients

Ahmed, T., Shimizu, T. S., & Stocker, R. (2010) · Nano Letters · doi:10.1021/nl101204e · Cited by 165 · see citing works

Generating fixed concentration arrays in a microfluidic device

Holden, M. A., Kumar, S., Castellana, E. T., Beşkök, A., & Cremer, P. S. (2003) · Sensors and Actuators B Chemical · doi:10.1016/s0925-4005(03)00129-1 · Cited by 161 · see citing works

A high-throughput microfluidic assay to study neurite response to growth factor gradients

Kothapalli, C. R., van Veen, J. E., de Valence, S., Chung, S. H., Zervantonakis, I. K., Gertler, F. B., & Kamm, R. D. (2010) · Lab on a Chip · doi:10.1039/c0lc00240b · Cited by 161 · see citing works

A Miniaturized, Parallel, Serially Diluted Immunoassay for Analyzing Multiple Antigens

Jiang, X., Ng, J. M. K., Stroock, A. D., Dertinger, S. K. W., & Whitesides, G. M. (2003) · Journal of the American Chemical Society · doi:10.1021/ja034566+ · Cited by 160 · see citing works

The Signaling Mechanisms Underlying Cell Polarity and ChemotaxisPreprint

Wang, F. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a002980 · Cited by 156 · see citing works

Combinatorial mixing of microfluidic streams

NEILS, C. M., Tyree, Z., Finlayson, B. A., & Folch, A. (2004) · Lab on a Chip · doi:10.1039/b314962e · Cited by 154 · see citing works

A polydimethylsiloxane–polycarbonate hybrid microfluidic device capable of generating perpendicular chemical and oxygen gradients for cell culture studies

Chang, C.-W., Cheng, Y.-J., Tu, M., Chen, Y.-H., Peng, C.-C., Liao, W.-H., & Tung, Y.-C. (2014) · Lab Chip · doi:10.1039/c4lc00732h · Cited by 154 · see citing works

A General Method for Patterning Gradients of Biomolecules on Surfaces Using Microfluidic Networks

Jiang, X., Xu, Q., Dertinger, S. K. W., Stroock, A. D., Fu, T., & Whitesides, G. M. (2005) · Analytical Chemistry · doi:10.1021/ac048440m · Cited by 154 · see citing works

The microfluidic palette: A diffusive gradient generator with spatio-temporal control

Atencia, J., Morrow, J. B., & Locascio, L. E. (2009) · Lab on a Chip · doi:10.1039/b902113b · Cited by 154 · see citing works

Polar stimulation and constrained cell migration in microfluidic channels

Irimia, D., Charras, G., Agrawal, N., Mitchison, T. J., & Toner, M. (2007) · Lab on a Chip · doi:10.1039/b710524j · Cited by 149 · see citing works

Generalized serial dilution module for monotonic and arbitrary microfluidic gradient generators

Lee, K., Kim, C., Ahn, B., Panchapakesan, R., Full, A. R., Nordee, L., Kang, J. Y., & Oh, K. W. (2008) · Lab on a Chip · doi:10.1039/b813582g · Cited by 145 · see citing works

On-Chip Titration of an Anticoagulant Argatroban and Determination of the Clotting Time within Whole Blood or Plasma Using a Plug-Based Microfluidic System

Song, H., Li, H., Munson, M. S., Ha, T. G. V., & Ismagilov, R. F. (2006) · Analytical Chemistry · doi:10.1021/ac0601718 · Cited by 144 · see citing works

Chemotaxis of Cell Populations through Confined Spaces at Single-Cell Resolution

Tong, Z., Balzer, E. M., Dallas, M. R., Hung, W.-C., Stebe, K. J., & Κωνσταντόπουλος, Κ. (2012) · PLoS ONE · doi:10.1371/journal.pone.0029211 · Cited by 141 · see citing works

A microfluidics-based turning assay reveals complex growth cone responses to integrated gradients of substrate-bound ECM molecules and diffusible guidance cues

Wang, C. J., Li, X., Lin, B., Shim, S., Ming, G., & Levchenko, A. (2008) · Lab on a Chip · doi:10.1039/b713945d · Cited by 140 · see citing works

Microfluidic static droplet arrays with tuneable gradients in material composition

Sun, M. Z., Bithi, S. S., & Vanapalli, S. A. (2011) · Lab on a Chip · doi:10.1039/c1lc20709a · Cited by 136 · see citing works

Microfluidic Gradient-Generating Device for Pharmacological Profiling

Pihl, J., Sinclair, J., Sahlin, E., Karlsson, M., Petterson, F., Olofsson, J., & Orwar, O. (2005) · Analytical Chemistry · doi:10.1021/ac050218+ · Cited by 135 · see citing works

A platform for assessing chemotactic migration within a spatiotemporally defined 3D microenvironment

Abhyankar, V. V., Toepke, M. W., Cortesio, C. L., Lokuta, M. A., Anna Huttenlocher, A., & Beebe, D. J. (2008) · Lab on a Chip · doi:10.1039/b803533d · Cited by 134 · see citing works

Flow-Based Microfluidic Device for Quantifying Bacterial Chemotaxis in Stable, Competing Gradients

Englert, D. L., Manson, M. D., & Jayaraman, A. (2009) · Applied and Environmental Microbiology · doi:10.1128/aem.02952-08 · Cited by 126 · see citing works

Combining rails and anchors with laser forcing for selective manipulation within 2D droplet arrays

Fradet, E., McDougall, C., Abbyad, P., Dangla, R., McGloin, D., & Baroud, C. N. (2011) · Lab on a Chip · doi:10.1039/c1lc20541b · Cited by 119 · see citing works

Novel PDMS cylindrical channels that generate coaxial flow, and application to fabrication of microfibers and particles

Kang, E., Shin, S.-J., Lee, K. H., & Lee, S. (2010) · Lab on a Chip · doi:10.1039/c002695f · Cited by 119 · see citing works

Sprouting Angiogenesis under a Chemical Gradient Regulated by Interactions with an Endothelial Monolayer in a Microfluidic Platform

Jeong, G. S., Han, S., Shin, Y., Kwon, G. H., Kamm, R. D., Lee, S., & Chung, S. H. (2011) · Analytical Chemistry · doi:10.1021/ac202170e · Cited by 119 · see citing works

A serial dilution microfluidic device using a ladder network generating logarithmic or linear concentrations

Kim, C., Lee, K., Kim, J., Shin, K. S., Lee, K., Kim, T. S., & Kang, J. Y. (2008) · Lab on a Chip · doi:10.1039/b714536e · Cited by 119 · see citing works

High-throughput automated droplet microfluidic system for screening of reaction conditions

Churski, K., Korczyk, P. M., & Garstecki, P. (2010) · Lab on a Chip · doi:10.1039/b925500a · Cited by 118 · see citing works

Robust Spatial Sensing of Mating Pheromone Gradients by Yeast Cells

Moore, T. I., Chou, C., Nie, Q. H., Jeon, N. L., & Yi, T. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003865 · Cited by 117 · see citing works

On the flow topology inside droplets moving in rectangular microchannels

Ma, S., Sherwood, J. M., Huck, W. T. S., & Balabani, S. (2014) · Lab on a Chip · doi:10.1039/c4lc00671b · Cited by 116 · see citing works

Molecular diffusive scaling laws in pressure-driven microfluidic channels: deviation from one-dimensional Einstein approximations

Kamholz, A. E., & Yager, P. (2002) · Sensors and Actuators B Chemical · doi:10.1016/s0925-4005(01)00990-x · Cited by 113 · see citing works

Mixed hydrogel bead-based tumor spheroid formation and anticancer drug testing

Wang, Y., & Wang, J. (2014) · The Analyst · doi:10.1039/c4an00015c · Cited by 110 · see citing works

Generation of Stable Complex Gradients Across Two-Dimensional Surfaces and Three-Dimensional Gels

Mosadegh, B., Huang, C. P., Park, J. W., Shin, H. S., Chung, B. G., Hwang, S., Lee, K., Kim, H. J., Brody, J. P., & Jeon, N. L. (2007) · Langmuir · doi:10.1021/la7026835 · Cited by 109 · see citing works

Gradient generation by an osmotic pump and the behavior of human mesenchymal stem cells under the fetal bovine serum concentration gradient

Park, J. Y., Hwang, C. M., Lee, S. H., & Lee, S.-H. (2007) · Lab on a Chip · doi:10.1039/b710777c · Cited by 109 · see citing works

Droplet-Based Microfluidic Flow Injection System with Large-Scale Concentration Gradient by a Single Nanoliter-Scale Injection for Enzyme Inhibition Assay

Cai, L., Zhu, Y., Du, G.-S., & Fang, Q. (2011) · Analytical Chemistry · doi:10.1021/ac2029198 · Cited by 108 · see citing works

A microfluidic device based on droplet storage for screening solubility diagrams

Laval, P., Lisai, N., Salmon, J., & Joanicot, M. (2007) · Lab on a Chip · doi:10.1039/b700799j · Cited by 107 · see citing works

Neutrophil Migration in Opposing Chemoattractant Gradients Using Microfluidic Chemotaxis Devices

Lin, F., Nguyen, C. M.-C., Wang, S., Saadi, W. M., Gross, S. P., & Jeon, N. L. (2005) · Annals of Biomedical Engineering · doi:10.1007/s10439-005-2503-6 · Cited by 106 · see citing works

A microfluidic multi-injector for gradient generation

Chung, B. G., Lin, F., & Jeon, N. L. (2006) · Lab on a Chip · doi:10.1039/b512667c · Cited by 104 · see citing works

Generation of Complex, Static Solution Gradients in Microfluidic Channels

Wu, H., Huang, B., & Zare, R. N. (2006) · Journal of the American Chemical Society · doi:10.1021/ja058530o · Cited by 104 · see citing works

An automated two-phase microfluidic system for kinetic analyses and the screening of compound libraries

Clausell-Tormos, J., Griffiths, A. D., & Merten, C. A. (2010) · Lab on a Chip · doi:10.1039/b921754a · Cited by 104 · see citing works

Multifunctional Picoliter Droplet Manipulation Platform and Its Application in Single Cell Analysis

Gu, S., Zhang, Y., Zhu, Y., Du, W., Yao, B., & Fang, Q. (2011) · Analytical Chemistry · doi:10.1021/ac201678g · Cited by 101 · see citing works

Generation of complex concentration profiles in microchannels in a logarithmically small number of steps

Campbell, K., & Groisman, A. (2006) · Lab on a Chip · doi:10.1039/b610011b · Cited by 98 · see citing works

A review of chemical gradient systems for cell analysis

Somaweera, H., Ibraguimov, A., & Pappas, D. (2016) · Analytica Chimica Acta · doi:10.1016/j.aca.2015.12.008 · Cited by 98 · see citing works

Droplet microfluidics for characterizing the neurotoxin-induced responses in individual Caenorhabditis elegans

Shi, W., Wen, H., Lu, Y., Shi, Y., Lin, B., & Qin, J. (2010) · Lab on a Chip · doi:10.1039/c0lc00256a · Cited by 95 · see citing works

A Fully Unsupervised Compartment-on-Demand Platform for Precise Nanoliter Assays of Time-Dependent Steady-State Enzyme Kinetics and Inhibition

Gielen, F., van Vliet, L., Koprowski, B. T., Devenish, S. R. A., Fischlechner, M., Edel, J. B., Niu, X., deMello, A. J., & Hollfelder, F. (2013) · Analytical Chemistry · doi:10.1021/ac400480z · Cited by 93 · see citing works

Electro-Coalescence of Digitally Controlled Droplets

Niu, X., Gielen, F., deMello, A. J., & Edel, J. B. (2009) · Analytical Chemistry · doi:10.1021/ac901188n · Cited by 92 · see citing works

High-Throughput Analysis of Protein–Protein Interactions in Picoliter-Volume Droplets Using Fluorescence Polarization

Choi, J.-W., Kang, D., Park, H. W., deMello, A. J., & Chang, S. (2012) · Analytical Chemistry · doi:10.1021/ac300414g · Cited by 92 · see citing works

Enhanced Transverse Migration of Bacteria by Chemotaxis in a Porous T-Sensor

Long, T., & Ford, R. M. (2009) · Environmental Science & Technology · doi:10.1021/es802558j · Cited by 92 · see citing works

Chemical stimulation of the Arabidopsis thaliana root using multi-laminar flow on a microfluidic chip

Meier, M., Lucchetta, E. M., & Ismagilov, R. F. (2010) · Lab on a Chip · doi:10.1039/c004629a · Cited by 92 · see citing works

Microfluidic device generating stable concentration gradients for long term cell culture: application to Wnt3a regulation of β-catenin signaling

Cimetta, E., Cannizzaro, C., James, R. G., Biechele, T. L., Moon, R. T., Elvassore, N., & Vunjak‐Novakovic, G. (2010) · Lab on a Chip · doi:10.1039/c0lc00033g · Cited by 89 · see citing works

Automated Microfluidic Screening Assay Platform Based on DropLab

Du, W., Sun, M. Z., Gu, S., Zhu, Y., & Fang, Q. (2010) · Analytical Chemistry · doi:10.1021/ac1020479 · Cited by 88 · see citing works

Multiplex analysis of enzyme kinetics and inhibition by droplet microfluidics using picoinjectors

Sjostrom, S. L., Joensson, H. N., & Svahn, H. A. (2013) · Lab on a Chip · doi:10.1039/c3lc41398e · Cited by 88 · see citing works

Orf virus interferes with MHC class I surface expression by targeting vesicular transport and Golgi

Rohde, J., Emschermann, F., Knittler, M. R., & Rziha, H.-J. (2012) · BMC Veterinary Research · doi:10.1186/1746-6148-8-114 · Cited by 85 · see citing works

Enzyme Kinetic Measurements Using a Droplet-Based Microfluidic System with a Concentration Gradient

Bui, M.-P. N., Li, C. A., Han, K. N., Choo, J., Lee, E. K., & Seong, G. H. (2011) · Analytical Chemistry · doi:10.1021/ac102472a · Cited by 84 · see citing works

Modular microfluidics for gradient generation

Sun, K., Wang, Z., & Jiang, X. (2008) · Lab on a Chip · doi:10.1039/b806140h · Cited by 82 · see citing works

Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells

Torisawa, Y., Mosadegh, B., Bersano-Begey, T. F., Steele, J. M., Luker, K. E., Luker, G. D., & Takayama, S. (2010) · Integrative Biology · doi:10.1039/c0ib00041h · Cited by 81 · see citing works

Cell infection within a microfluidic device using virus gradients

Walker, G. M. (2003) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2003.10.014 · Cited by 78 · see citing works

A microfluidic cell culture array with various oxygen tensions

Peng, C., Liao, W., Chen, Y., Wu, C., & Tung, Y. (2013) · Lab on a Chip · doi:10.1039/c3lc50388g · Cited by 78 · see citing works

Microfluidic Serial Dilution Cell-Based Assay for Analyzing Drug Dose Response over a Wide Concentration Range

Sugiura, S., Hattori, K., & Kanamori, T. (2010) · Analytical Chemistry · doi:10.1021/ac1017666 · Cited by 78 · see citing works

Investigation of bacterial chemotaxis in flow-based microfluidic devices

Englert, D. L., Manson, M. D., & Jayaraman, A. (2010) · Nature Protocols · doi:10.1038/nprot.2010.18 · Cited by 77 · see citing works

A robust diffusion-based gradient generator for dynamic cell assays

Atencia, J., Cooksey, G. A., & Locascio, L. E. (2011) · Lab on a Chip · doi:10.1039/c1lc20829b · Cited by 74 · see citing works

Ischemia/reperfusion injury of primary porcine cardiomyocytes in a low-shear microfluidic culture and analysis device

Khanal, G., Chung, K. Y., Solis-Wever, X., Johnson, B. J., & Pappas, D. (2011) · The Analyst · doi:10.1039/c0an00845a · Cited by 70 · see citing works

Generation of stable orthogonal gradients of chemical concentration and substrate stiffness in a microfluidic device

García, S., Sunyer, R., Olivares, A. L., Noailly, J., Atencia, J., & Trepat, X. (2015) · Lab on a Chip · doi:10.1039/c5lc00140d · Cited by 70 · see citing works

Simultaneous measurement of reactions in microdroplets filled by concentration gradients

Damean, N. A., Olguín, L. F., Hollfelder, F., Abell, C., & Huck, W. T. S. (2009) · Lab on a Chip · doi:10.1039/b821021g · Cited by 69 · see citing works

Rapid spatial and temporal controlled signal delivery over large cell culture areas

VanDersarl, J. J., Xu, A. M., & Melosh, N. A. (2011) · Lab on a Chip · doi:10.1039/c1lc20311h · Cited by 67 · see citing works

Stationary nanoliter droplet array with a substrate of choice for single adherent/nonadherent cell incubation and analysis

Shemesh, J., Arye, T. B., Avesar, J., Kang, J. H., Fine, A., Super, M., Meller, A., Ingber, D. E., & Levenberg, S. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404472111 · Cited by 63 · see citing works

Flow-switching allows independently programmable, extremely stable, high-throughput diffusion-based gradients

Frank, T., & Tay, S. (2013) · Lab on a Chip · doi:10.1039/c3lc41076e · Cited by 63 · see citing works

Microfluidic static droplet array for analyzing microbial communication on a population gradient

Jeong, H., Jin, S. H., Lee, B. J., Kim, T., & Lee, C. (2014) · Lab on a Chip · doi:10.1039/c4lc01097c · Cited by 63 · see citing works

A droplet microchip with substance exchange capability for the developmental study of C. elegans

Wen, H., Yu, Y., Zhu, G., Jiang, L., & Qin, J. (2015) · Lab on a Chip · doi:10.1039/c4lc01377h · Cited by 63 · see citing works

A programmable microfluidic static droplet array for droplet generation, transportation, fusion, storage, and retrieval

Jin, S. H., Jeong, H., Lee, B., Lee, S. S., & Lee, C. (2015) · Lab on a Chip · doi:10.1039/c5lc00651a · Cited by 62 · see citing works

Droplet-Based Microfluidic Platform for High-Throughput, Multi-Parameter Screening of Photosensitizer Activity

Cho, S., Kang, D., Sim, S., Geier, F. M., Kim, J., Niu, X., Edel, J. B., Chang, S., Wootton, R. C. R., Elvira, K. S., et al. (2013) · Analytical Chemistry · doi:10.1021/ac4022067 · Cited by 62 · see citing works

Uncovering toxicological complexity by multi-dimensional screenings in microsegmented flow: modulation of antibiotic interference by nanoparticles

Cao, J., Kürsten, D., Schneider, S., Knauer, A., Günther, P. M., & Köhler, J. M. (2011) · Lab on a Chip · doi:10.1039/c1lc20584f · Cited by 60 · see citing works

Microfluidic delivery of small molecules into mammalian cells based on hydrodynamic focusing

Wang, F., Wang, H., Wang, J., Wang, H.-Y. A., Rummel, P. L., Garimella, S. V., & Lu, C. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21737 · Cited by 60 · see citing works

Systematic modeling of microfluidic concentration gradient generators

Wang, Y., Mukherjee, T., & Lin, Q. (2006) · Journal of Micromechanics and Microengineering · doi:10.1088/0960-1317/16/10/029 · Cited by 59 · see citing works

Generation of arbitrary monotonic concentration profiles by a serial dilution microfluidic network composed of microchannels with a high fluidic-resistance ratio

Hattori, K., Sugiura, S., & Kanamori, T. (2009) · Lab on a Chip · doi:10.1039/b816995k · Cited by 59 · see citing works

Microfluidic traps for hard-wired operations on droplets

Korczyk, P. M., Derzsi, L., Jakieła, S., & Garstecki, P. (2013) · Lab on a Chip · doi:10.1039/c3lc50347j · Cited by 58 · see citing works

3D Droplet Microfluidic Systems for High-Throughput Biological Experimentation

Kang, D., Gong, X., Cho, S., Kim, J., Edel, J. B., Chang, S., Choo, J., & deMello, A. J. (2015) · Analytical Chemistry · doi:10.1021/acs.analchem.5b02402 · Cited by 55 · see citing works

Automated generation of libraries of nL droplets

Kamiński, T. S., Jakieła, S., Czekalska, M. A., Postek, W., & Garstecki, P. (2012) · Lab on a Chip · doi:10.1039/c2lc40540g · Cited by 53 · see citing works

Microfluidic Perfusion System for Automated Delivery of Temporal Gradients to Islets of Langerhans

Zhang, X., & Roper, M. G. (2008) · Analytical Chemistry · doi:10.1021/ac802579z · Cited by 53 · see citing works

Microdroplet coalescences at microchannel junctions with different collision angles

Wang, K., Lü, Y., Lu, Y., & Luo, G. (2012) · AIChE Journal · doi:10.1002/aic.13825 · Cited by 52 · see citing works

Valve-based microfluidic device for droplet on-demand operation and static assay

Guo, F., Liu, K., Ji, X., Ding, H., Zhang, M., Zeng, Q., Liu, W., Guo, S., & Zhao, X. (2010) · Applied Physics Letters · doi:10.1063/1.3521283 · Cited by 52 · see citing works

Microfabricated analytical systems for integrated cancer cytomics

Włodkowic, D., & Cooper, J. M. (2010) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-010-3722-8 · Cited by 51 · see citing works

Generation of Picoliter Droplets with Defined Contents and Concentration Gradients from the Separation of Chemical Mixtures

Theberge, A. B., Whyte, G., & Huck, W. T. S. (2010) · Analytical Chemistry · doi:10.1021/ac1005316 · Cited by 50 · see citing works

Creation of Stepwise Concentration Gradient in Picoliter Droplets for Parallel Reactions of Matrix Metalloproteinase II and IX

Jambovane, S. R., Kim, D. J., Duin, E. C., Kim, S., & Hong, J. W. (2011) · Analytical Chemistry · doi:10.1021/ac103217p · Cited by 49 · see citing works

Blood plasma separation in a long two-phase plug flowing through disposable tubing

Sun, M. Z., Khan, Z. S., & Vanapalli, S. A. (2012) · Lab on a Chip · doi:10.1039/c2lc40544j · Cited by 49 · see citing works

High-throughput single cell multidrug resistance analysis with multifunctional gradients-customizing microfluidic device

Li, Y., Chen, D., Zhang, Y., Liu, C., Chen, P., Wang, Y., Feng, X., Du, W., & Liu, B. (2015) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2015.11.097 · Cited by 48 · see citing works

A highly addressable static droplet array enabling digital control of a single droplet at pico-volume resolution

Jeong, H., Lee, B., Jin, S. H., Jeong, S., & Lee, C. (2016) · Lab on a Chip · doi:10.1039/c6lc00212a · Cited by 48 · see citing works

Controlled dispensing and mixing of pico- to nanoliter volumes using on-demand droplet-based microfluidics

Sun, X., Tang, K., Smith, R. D., & Kelly, R. (2013) · Microfluidics and Nanofluidics · doi:10.1007/s10404-012-1133-1 · Cited by 46 · see citing works

An integrated microfluidic culture device to regulate endothelial cell differentiation from embryonic stem cells

Lee, J. M., Kim, J., Kang, E., Lee, S., & Chung, B. G. (2011) · Electrophoresis · doi:10.1002/elps.201100161 · Cited by 46 · see citing works

Antibiograms in five pipetting steps: precise dilution assays in sub-microliter volumes with a conventional pipette

Derzsi, L., Kamiński, T. S., & Garstecki, P. (2016) · Lab on a Chip · doi:10.1039/c5lc01151e · Cited by 45 · see citing works

Microalgal motility measurement microfluidic chip for toxicity assessment of heavy metals

Zheng, G., Wang, Y., & Qin, J. (2012) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-012-6408-6 · Cited by 44 · see citing works

A simple and versatile microfluidic cell density gradient generator for quantum dot cytotoxicity assay

Wu, J., Chen, Q., Liu, W., & Lin, J. (2013) · Lab on a Chip · doi:10.1039/c3lc00041a · Cited by 44 · see citing works

A microfluidic concentration-gradient droplet array generator for the production of multi-color nanoparticles

Yang, C., Xu, Z., Lee, A. P., & Wang, J. (2013) · Lab on a Chip · doi:10.1039/c3lc50254f · Cited by 43 · see citing works

Block-and-break generation of microdroplets with fixed volume

van Steijn, V., Korczyk, P. M., Derzsi, L., Abate, A. R., Weitz, D. A., & Garstecki, P. (2013) · Biomicrofluidics · doi:10.1063/1.4801637 · Cited by 42 · see citing works

Concentration landscape generators for shear free dynamic chemical stimulation

Morel, M., Galas, J.-C., Dahan, M., & Studer, V. (2012) · Lab on a Chip · doi:10.1039/c2lc20994b · Cited by 42 · see citing works

Simultaneous generation of multiple aqueous droplets in a microfluidic device

Lorenz, R. M., Fiorini, G. S., Jeffries, G. D. M., Lim, D. S. W., He, M., & Chiu, D. T. (2008) · Analytica Chimica Acta · doi:10.1016/j.aca.2008.10.009 · Cited by 41 · see citing works

A low resistance microfluidic system for the creation of stable concentration gradients in a defined 3D microenvironment

Amadi, O. C., Steinhauser, M. L., Nishi, Y., Chung, S. H., Kamm, R. D., McMahon, A. P., & Lee, R. T. (2010) · Biomedical Microdevices · doi:10.1007/s10544-010-9457-7 · Cited by 41 · see citing works

Cell differentiation guidance using chemical stimulation controlled by a microfluidic device

Nakashima, Y., & Yasuda, T. (2007) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2007.05.035 · Cited by 41 · see citing works

Interfacing Microwells with Nanoliter Compartments: A Sampler Generating High-Resolution Concentration Gradients for Quantitative Biochemical Analyses in Droplets

Gielen, F., Buryška, T., van Vliet, L., Butz, M., Damborský, J., Prokop, Z., & Hollfelder, F. (2014) · Analytical Chemistry · doi:10.1021/ac503336g · Cited by 40 · see citing works

Coalescing drops in microfluidic parking networks: A multifunctional platform for drop-based microfluidics

Bithi, S. S., Wang, W. S., Sun, M. Z., Bławzdziewicz, J., & Vanapalli, S. A. (2014) · Biomicrofluidics · doi:10.1063/1.4885079 · Cited by 39 · see citing works

A microfluidic localized, multiple cell culture array using vacuum actuated cell seeding: integrated anticancer drug testing

Gao, Y., Li, P., & Pappas, D. (2013) · Biomedical Microdevices · doi:10.1007/s10544-013-9779-3 · Cited by 39 · see citing works

Generation of complex concentration profiles by partial diffusive mixing in multi-stream laminar flow

Zhou, Y., Wang, Y., Mukherjee, T., & Lin, Q. (2009) · Lab on a Chip · doi:10.1039/b818485b · Cited by 38 · see citing works

Droplet-based microfluidic device for multiple-droplet clustering

Xu, J. J., Ahn, B., Lee, H., Xu, L., Lee, K., Panchapakesan, R., & Oh, K. W. (2011) · Lab on a Chip · doi:10.1039/c2lc20883k · Cited by 38 · see citing works

Small-molecule axon-polarization studies enabled by a shear-free microfluidic gradient generator

Xu, H., Ferreira, M. M., & Heilshorn, S. C. (2014) · Lab on a Chip · doi:10.1039/c4lc00162a · Cited by 36 · see citing works

A microfluidic concentration generator for dose-response assays on ion channel pharmacology

Chen, C.-Y., Wo, A. M., & Jong, D. (2012) · Lab on a Chip · doi:10.1039/c1lc20548j · Cited by 36 · see citing works

A Brazilian Population of the Asexual Fungus-Growing Ant Mycocepurus smithii (Formicidae, Myrmicinae, Attini) Cultivates Fungal Symbionts with Gongylidia-Like Structures

Masiulionis, V. E., Rabeling, C., Licht, H. H. D. F., Schultz, T. R., Bacci, M., Bezerra, C. M. S., & Pagnocca, F. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103800 · Cited by 35 · see citing works

The microenvironment of double emulsions in rectangular microchannels

Ma, S., Sherwood, J. M., Huck, W. T. S., & Balabani, S. (2015) · Lab on a Chip · doi:10.1039/c5lc00346f · Cited by 35 · see citing works

Characterization of transport in microfluidic gradient generators

Gorman, B. R., & Wikswo, J. P. (2007) · Microfluidics and Nanofluidics · doi:10.1007/s10404-007-0169-0 · Cited by 32 · see citing works

Electrokinetic concentration gradient generation using a converging–diverging microchannel

Lee, J. S. H., Hu, Y., & Li, D. (2005) · Analytica Chimica Acta · doi:10.1016/j.aca.2005.04.041 · Cited by 32 · see citing works

Generation of droplets with different concentrations using gradient-microfluidic droplet generator

Yeh, C.-H., Chen, Y., & Lin, Y.-C. (2011) · Microfluidics and Nanofluidics · doi:10.1007/s10404-011-0791-8 · Cited by 32 · see citing works

Microfluidic flow-free generation of chemical concentration gradients

Zhou, Y., & Lin, Q. (2013) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2013.08.073 · Cited by 31 · see citing works

A facile on-demand droplet microfluidic system for lab-on-a-chip applications

Zhou, H., & Yao, S. (2013) · Microfluidics and Nanofluidics · doi:10.1007/s10404-013-1268-8 · Cited by 30 · see citing works

Droplet coalescence at microchannel intersection chambers with different shapes

Liu, Z., Wang, X., Cao, R., & Pang, Y. (2016) · Soft Matter · doi:10.1039/c6sm01158f · Cited by 30 · see citing works

Fabrication of a microfluidic chip containing dam, weirs and gradient generator for studying cellular response to chemical modulation

Ruan, J., Wang, L., Xu, M., Cui, D., Zhou, X., & Liu, D. (2008) · Materials Science and Engineering C · doi:10.1016/j.msec.2008.12.009 · Cited by 28 · see citing works

Real-time luminescence-based colorimetric determination of double-strand DNA in droplet on demand

Xiang, X., Chen, L., Zhuang, Q., Ji, X., & He, Z. (2011) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2011.11.013 · Cited by 28 · see citing works

High Throughput Assay of Diffusion through Cx43 Gap Junction Channels with a Microfluidic Chip

Bathany, C., Beahm, D. L., Felske, J. D., Sachs, F., & Hua, S. Z. (2010) · Analytical Chemistry · doi:10.1021/ac102658h · Cited by 28 · see citing works

Generation of Chemical Concentration Gradients in Mobile Droplet Arrays via Fragmentation of Long Immiscible Diluting Plugs

Sun, M., & Vanapalli, S. A. (2013) · Analytical Chemistry · doi:10.1021/ac303526y · Cited by 26 · see citing works

A microfluidic device that forms and redirects pheromone gradients to study chemotropism in yeast

Brett, M., DeFlorio, R., Stone, D. E., & Eddington, D. (2012) · Lab on a Chip · doi:10.1039/c2lc40398f · Cited by 26 · see citing works

Temporal gradients in microfluidic systems to probe cellular dynamics: A review

Dhumpa, R., & Roper, M. G. (2012) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.07.006 · Cited by 24 · see citing works

2-layer based microfluidic concentration generator by hybrid serial and volumetric dilutions

Lee, K., Kim, C., Kim, Y., Jung, K., Ahn, B., Kang, J. Y., & Oh, K. W. (2010) · Biomedical Microdevices · doi:10.1007/s10544-009-9385-6 · Cited by 24 · see citing works

On‐Site Formation of Emulsions by Controlled Air Plugs

Huang, X., Hui, W., Hao, C., Yue, W., Yang, M., Cui, Y., & Wang, Z. (2013) · Small · doi:10.1002/smll.201202659 · Cited by 24 · see citing works

Integrated pneumatic micro-pumps for high-throughput droplet-based microfluidics

Choi, J.-W., Lee, S., Lee, D. H., Kim, J., deMello, A. J., & Chang, S. (2014) · RSC Advances · doi:10.1039/c4ra02033b · Cited by 22 · see citing works

Overexpression of chemokine ligand 7 is associated with the progression of canine transmissible venereal tumor

Chiang, H.-C., Wang, Y., Chou, C., Liao, A. T., Chu, R., & Lin, C. (2012) · BMC Veterinary Research · doi:10.1186/1746-6148-8-216 · Cited by 22 · see citing works

Combinatorial generation of droplets by controlled assembly and coalescence

Um, E., Rogers, M., & Stone, H. A. (2013) · Lab on a Chip · doi:10.1039/c3lc50957e · Cited by 21 · see citing works

On-chip gradient generation in 256 microfluidic cell cultures: simulation and experimental validation

Somaweera, H., Haputhanthri, S. O., Ibraguimov, A., & Pappas, D. (2015) · The Analyst · doi:10.1039/c5an00481k · Cited by 21 · see citing works

Coalescence-assisted generation of single nanoliter droplets with predefined composition

Shemesh, J., Nir, A., Bransky, A., & Levenberg, S. (2011) · Lab on a Chip · doi:10.1039/c0lc00730g · Cited by 20 · see citing works

Novel microsystems for concentration gradient generation through computer optimization with validation using optical instrumentation

Yusuf, H. A., Baldock, S. J., Barber, R. W., Fielden, P. R., Goddard, N. J., & Brown, B. J. T. (2008) · Microelectronic Engineering · doi:10.1016/j.mee.2007.12.052 · Cited by 20 · see citing works

Microfluidic architectures for efficient generation of chemistry gradations in droplets

Węgrzyn, J., Samborski, A., Reissig, L., Korczyk, P. M., Błoński, S., & Garstecki, P. (2012) · Microfluidics and Nanofluidics · doi:10.1007/s10404-012-1042-3 · Cited by 20 · see citing works

Spatially selective reagent delivery into cancer cells using a two-layer microfluidic culture system

Liu, Y., Butler, W. B., & Pappas, D. (2012) · Analytica Chimica Acta · doi:10.1016/j.aca.2012.06.054 · Cited by 19 · see citing works

Rapid modulation of droplet composition with pincer microvalves

Ochs, C. J., & Abate, A. R. (2014) · Lab on a Chip · doi:10.1039/c4lc01040j · Cited by 18 · see citing works

Optimisation and analysis of microreactor designs for microfluidic gradient generation using a purpose built optical detection system for entire chip imaging

Yusuf, H. A., Baldock, S. J., Barber, R. W., Fielden, P. R., Goddard, N. J., Mohr, S., & Brown, B. J. T. (2009) · Lab on a Chip · doi:10.1039/b823101j · Cited by 17 · see citing works

Generation of tunable and pulsatile concentration gradients via microfluidic network

Zhou, B., Xu, W. X., Wang, C., Chau, Y. Y., Zeng, X., Zhang, X., Shen, R., & Wen, W. (2014) · Microfluidics and Nanofluidics · doi:10.1007/s10404-014-1432-9 · Cited by 16 · see citing works

Assay for molecular transport across gap junction channels in one-dimensional cell arrays

Ye, N., Bathany, C., & Hua, S. Z. (2011) · Lab on a Chip · doi:10.1039/c0lc00350f · Cited by 16 · see citing works

Electrocoalescence based serial dilution of microfluidic droplets

Bhattacharjee, B., & Vanapalli, S. A. (2014) · Biomicrofluidics · doi:10.1063/1.4891775 · Cited by 16 · see citing works

Generation of a chemical gradient across an array of 256 cell cultures in a single chip

Somaweera, H., Ibragimov, A., & Pappas, D. (2013) · The Analyst · doi:10.1039/c3an00946g · Cited by 16 · see citing works

Finite element modelling and design of a concentration gradient generating bioreactor: Application to biological pattern formation and toxicology

Vozzi, G., Mazzei, D., Tirella, A., Vozzi, F., & Ahluwalia, A. D. (2010) · Toxicology in Vitro · doi:10.1016/j.tiv.2010.05.010 · Cited by 15 · see citing works

Chemical neurostimulation using pulse code modulation (PCM) microfluidic chips

Azizi, F., Lu, H., Chiel, H. J., & Mastrangelo, C. H. (2010) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2010.07.011 · Cited by 15 · see citing works

Polymer Brushes Patterned with Micrometer-Scale Chemical Gradients Using Laminar Co-Flow

Koo, H., Waynant, K. V., Zhang, C., & Braun, P. V. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am503609x · Cited by 15 · see citing works

High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment

Rosa, P. M., Tenreiro, S., Chu, V., Outeiro, T. F., & Conde, J. P. (2012) · Biomicrofluidics · doi:10.1063/1.3683161 · Cited by 14 · see citing works

Electrokinetic generation of temporally and spatially stable concentration gradients in microchannels

Biddiss, E. A., & Li, D. (2005) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2005.03.037 · Cited by 11 · see citing works

Systematic linearisation of a microfluidic gradient network with unequal solution inlet viscosities demonstrated using glycerol

Yusuf, H. A., Baldock, S. J., Fielden, P. R., Goddard, N. J., Mohr, S., & Brown, B. J. T. (2009) · Microfluidics and Nanofluidics · doi:10.1007/s10404-009-0489-3 · Cited by 10 · see citing works

Chemical gradient‐mediated melting curve analysis for genotyping of SNPs

Russom, A., Irimia, D., & Toner, M. (2009) · Electrophoresis · doi:10.1002/elps.200800729 · Cited by 8 · see citing works

On-chip dilution in nanoliter droplets

Thakur, R., Amin, A. M., & Wereley, S. T. (2015) · The Analyst · doi:10.1039/c4an01829j · Cited by 5 · see citing works

Optical imaging and analytical modelling of the dynamic concentration gradient of viscous inlet solutions in a microfabricated network design

Yusuf, H. A., Baldock, S. J., Mohr, S., Fielden, P. R., Goddard, N. J., & Brown, B. J. T. (2009) · Microelectronic Engineering · doi:10.1016/j.mee.2009.01.011 · Cited by 5 · see citing works

Stepwise reagent introduction-based droplet platform for multiplexed DNA sensing

Xiang, X., Shi, L., Luo, M., Chen, J., Ji, X., & He, Z. (2013) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2013.05.026 · Cited by 3 · see citing works

Characterising the effect of geometry on a microchamber for producing controlled concentration gradients

Glover, K., Strang, J. A., & Lubansky, A. S. (2014) · Chemical Engineering Science · doi:10.1016/j.ces.2014.06.045 · Cited by 2 · see citing works

A guide to the organ-on-a-chip

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Efficient Synthesis of a Schiff Base Copper(II) Complex Using a Microfluidic Device

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