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The economies of synthesis
Open accessAbstract
In this tutorial review the economies of synthesis are analysed from both detailed and macroscopic perspectives, using case-studies from complex molecule synthesis. Atom, step, and redox economy are more than philosophical constructs, but rather guidelines, which enable the synthetic chemist to design and execute an efficient synthesis. Students entering the field of synthesis might find this tutorial helpful for understanding the subtle differences between these economic principles and also see real-world situations where such principles are put into practice.
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Citations
Cited by
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Newman, D. J., & Cragg, G. M. (2012) · Journal of Natural Products · doi:10.1021/np200906s · Cited by 4,687
Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
Kärkäs, M. D., Porco, J. A., & Stephenson, C. R. J. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00760 · Cited by 1,017
Yu, Z., Ma, B., Chen, M., Wu, H.-H., Liu, L., & Zhang, J. (2014) · Journal of the American Chemical Society · doi:10.1021/ja503163k · Cited by 451
Enzymatic functionalization of carbon–hydrogen bonds
Lewis, J. C., Coelho, P. S., & Arnold, F. H. (2011) · Chem. Soc. Rev. · doi:10.1039/c0cs00067a · Cited by 386
Chemo- and site-selective derivatizations of natural products enabling biological studies
Robles, O., & Romo, D. (2014) · Nat. Prod. Rep. · doi:10.1039/c3np70087a · Cited by 154
Metadata
- Authors
- Newhouse, T., Baran, P. S., & Hoffmann, R. W.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 38
- Issue
- 11
- Pages
- 3010
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W1982832174
- Cited by
- 807
- References
- 0
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- green
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