The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
A microfluidic 3D hepatocyte chip for drug toxicity testing
Abstract
We have developed a microfluidic 3D hepatocyte chip (3D HepaTox Chip) for in vitro drug toxicity testing to predict in vivo drug hepatotoxicity. The 3D HepaTox Chip is based on multiplexed microfluidic channels where a 3D microenvironment is engineered in each channel to maintain the hepatocytes' synthetic and metabolic functions. The multiplexed channels allow for simultaneous administration of multiple drug doses to functional primary hepatocytes while an incorporated concentration gradient generator enables the in vitro dose-dependent drug responses to predict in vivo hepatotoxicity. The IC(50) values of 5 model drugs derived from the dose-dependent on-chip testing correlate well with the reported in vivo LD(50) values. The 3D HepaTox Chip can be integrated with on-chip sensors and actuators as the next generation cell-based on-chip drug testing platform.
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Cites
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Cancer nanomedicine: progress, challenges and opportunities
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A guide to the organ-on-a-chip
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Self-citationMicrofluidic technologies for accelerating the clinical translation of nanoparticles
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Metadata
- Authors
- Toh, Y.-C., Lim, T. C., Tai, D., Xiao, G., van Noort, D., & Yu, H.
- Venue
- Lab on a Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Volume
- 9
- Issue
- 14
- Pages
- 2026
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2012867417
- Cited by
- 419
- References
- 37
- FWCI
- 14.36
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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