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Cited by 739

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Click chemistry with DNA

El-Sagheer, Afaf H., Brown, Tom·2010·Chemical Society Reviews

Abstract

The advent of click chemistry has led to an influx of new ideas in the nucleic acids field. The copper catalysed alkyne-azide cycloaddition (CuAAC) reaction is the method of choice for DNA click chemistry due to its remarkable efficiency. It has been used to label oligonucleotides with fluorescent dyes, sugars, peptides and other reporter groups, to cyclise DNA, to synthesise DNA catenanes, to join oligonucleotides to PNA, and to produce analogues of DNA with modified nucleobases and backbones. In this critical review we describe some of the pioneering work that has been carried out in this area (78 references).

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Metadata

Authors
El-Sagheer, A. H., & Brown, T.
Venue
Chemical Society Reviews
Published
2010
Volume
39
Issue
4
Pages
1388
ISSN
  • 0306-0012 (ISSN-L)
  • 1460-4744
OpenAlex
W2165372505
Cited by
739
References
1
FWCI
2.67
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Click chemistry with DNA. https://app.cochat.ai/papers/10.1039/b901971p
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El-Sagheer, A. H., & Brown, T. (2010). Click chemistry with DNA. Chemical Society Reviews. https://doi.org/10.1039/b901971p

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.