The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The topology of drug–target interaction networks: implicit dependence on drug properties and target families
Abstract
The availability of interaction data between small molecule drugs and protein targets has increased substantially in recent years. Using seven different databases, we were able to assemble a total of 4767 unique interactions between 802 drugs and 480 targets, which means that on average every drug is currently acknowledged to interact with 6 targets. The application of network theory to the analysis of these data reveals an unexpectedly complex picture of drug–target interactions. The results confirm that the topology of drug–target networks depends implicitly on data completeness, drug properties, and target families. The implications for drug discovery are discussed.
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Roth, B. L., Sheffler, D. J., & Kroeze, W. K. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1346 · Cited by 1,155
Can we rationally design promiscuous drugs?
HOPKINS, A., MASON, J., & OVERINGTON, J. (2006) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2006.01.013 · Cited by 469
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Uncovering disease-disease relationships through the incomplete interactome
Menche, J., Sharma, A., Kitsak, M., Ghiassian, S. D., Vidal, M., Loscalzo, J., & Barabási, A.-L. (2015) · Science · doi:10.1126/science.1257601 · Cited by 1,546
Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack
Ziegler, S., Pries, V., Hedberg, C., & Waldmann, H. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201208749 · Cited by 466
Polypharmacology – Foe or Friend?
Peters, J.-U. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm400856t · Cited by 465
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Boezio, B., Audouze, K., Ducrot, P., & Taboureau, O. (2017) · Molecular Informatics · doi:10.1002/minf.201700048 · Cited by 359
Metadata
- Authors
- Mestres, J., Gregori-Puigjané, E., Valverde, S., & Solé, R. V.
- Venue
- Molecular BioSystems
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-07-08
- Volume
- 5
- Issue
- 9
- Pages
- 1051-1057
- ISSN
- 1742-2051 (ISSN-L)
- 1742-206X
- OpenAlex
- W1992578437
- Cited by
- 203
- References
- 2
- FWCI
- 18.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mestres, J., Gregori-Puigjané, E., Valverde, S., & Solé, R. V. (2009). The topology of drug–target interaction networks: implicit dependence on drug properties and target families. Molecular BioSystems. https://doi.org/10.1039/b905821b
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