The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Metal-NHC complexes: a survey of anti-cancer properties
Abstract
New weapons to fight cancer are constantly needed. Among chemotherapeutics, anti-cancer metal-drugs have enjoyed a long and successful history since the discovery of the benchmark cisplatin. Advances in metal-drug discovery have motivated chemists to build plethora of complex structures. Among them, a novel area is emerging. This article presents a survey of the metal-N-Heterocyclic Carbenes (Ag(I), Au(I), Pd(II) and Cu(I)-NHCs) as potential anti-cancer agents. Most of the metal-NHCs considered display higher cytotoxicities than the reference metallo-drug cisplatin. Some of them are even selective for particular cell lines. Their mechanisms of action at the cellular level are further discussed, showing that the nature of the metal is of great importance. All these promising results demonstrate that this approach deserves more attention and work.
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Cites
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Siddik, Z. H. (2003) · Oncogene · doi:10.1038/sj.onc.1206933 · Cited by 3,335
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Inhibition of Cell Division in Escherichia coli by Electrolysis Products from a Platinum Electrode
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Cited by
Zhukhovitskiy, A. V., MacLeod, M. J., & Johnson, J. A. (2015) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00220 · Cited by 363
Metadata
- Authors
- Teyssot, M.-L., Jarrousse, A.-S., Manin, M., Chevry, A., Roche, S., Norre, F., Beaudoin, C., Morel, L., Boyer, D., Mahiou, R., & Gautier, A.
- Venue
- Dalton Transactions
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2009
- Issue
- 35
- Pages
- 6894
- ISSN
- 1477-9226 (ISSN-L)
- 1477-9234
- OpenAlex
- W2093345655
- Cited by
- 384
- References
- 33
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Teyssot, M.-L., Jarrousse, A.-S., Manin, M., Chevry, A., Roche, S., Norre, F., Beaudoin, C., Morel, L., Boyer, D., Mahiou, R., & Gautier, A. (2009). Metal-NHC complexes: a survey of anti-cancer properties. Dalton Transactions. https://doi.org/10.1039/b906308k
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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