The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans
Open accessAbstract
This article describes the fabrication of a microfluidic device for the liquid culture of many individual nematode worms (Caenorhabditis elegans) in separate chambers. Each chamber houses a single worm from the fourth larval stage until death, and enables examination of a population of individual worms for their entire adult lifespans. Adjacent to the chambers, the device includes microfluidic worm clamps, which enable periodic, temporary immobilization of each worm. The device made it possible to track changes in body size and locomotion in individual worms throughout their lifespans. This ability to perform longitudinal measurements within the device enabled the identification of age-related phenotypic changes that correlate with lifespan in C. elegans.
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Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214
Cited by
Micro Total Analysis Systems for Cell Biology and Biochemical Assays
Kovarik, M. L., Gach, P. C., Ornoff, D. M., Wang, Y., Balowski, J., Farrag, L., & Allbritton, N. L. (2012) · Analytical Chemistry · doi:10.1021/ac202611x · Cited by 270
Metadata
- Authors
- Hulme, S. E., Shevkoplyas, S. S., McGuigan, A. P., Apfeld, J., Fontana, W., & Whitesides, G. M.
- Venue
- Lab Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2010
- Volume
- 10
- Issue
- 5
- Pages
- 589-597
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2141906756
- Cited by
- 213
- References
- 2
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Hulme, S. E., Shevkoplyas, S. S., McGuigan, A. P., Apfeld, J., Fontana, W., & Whitesides, G. M. (2010). Lifespan-on-a-chip: microfluidic chambers for performing lifelong observation of C. elegans. Lab Chip. https://doi.org/10.1039/b919265d
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