Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

Herndon, Laura A.; Schmeissner, Peter J.; Dudaronek, Justyna M.; Brown, Paula A.; Listner, Kristin M.; Sakano, Yuko; Paupard, Marie C.; Hall, David H.; Driscoll, Monica

doi:10.1038/nature01135

Cited by 1,214Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceAutophagy in Disease and Therapy

Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans

Herndon, Laura A., Schmeissner, Peter J., Dudaronek, Justyna M., Brown, Paula A., Listner, Kristin M., Sakano, Yuko, Paupard, Marie C., Hall, David H. +1 more·2002·Nature

DOI 10.1038/nature01135

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Abstract

The nematode Caenorhabditis elegans is an important model for studying the genetics of ageing, with over 50 life-extension mutations known so far. However, little is known about the pathobiology of ageing in this species, limiting attempts to connect genotype with senescent phenotype. Using ultrastructural analysis and visualization of specific cell types with green fluorescent protein, we examined cell integrity in different tissues as the animal ages. We report remarkable preservation of the nervous system, even in advanced old age, in contrast to a gradual, progressive deterioration of muscle, resembling human sarcopenia. The age-1(hx546) mutation, which extends lifespan by 60-100%, delayed some, but not all, cellular biomarkers of ageing. Strikingly, we found strong evidence that stochastic as well as genetic factors are significant in C. elegans ageing, with extensive variability both among same-age animals and between cells of the same type within individuals.

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Ultrastructural studies in C. elegans showed vastly different rates of aging of tissues and cells in individual worms, ascribed largely to stochastic events, and the onset of degenerative changes was neither linear nor synchronized.
“Ultrastructural studies in C. elegans almost two decades ago hinted that it might not.30 The authors noted not only vastly different rates of aging of tissues and cells in individual worms, which they ascribed largely to stochastic events, but the onset of degenerative changes was neither linear nor synchronized.”
From Asynchronous, contagious and digital aging (2021) · cites this paper as [30]
In C. elegans, muscles undergo an aging-related ultrastructural deterioration (sarcopenia), whereas nervous system ultrastructure remains largely intact.
“In the model organism C. elegans the muscles undergo an aging-related ultrastructural deterioration (also referred to as sarcopenia), whereas nervous system ultrastructure remains largely intact(Herndon et al., 2002).”
From Programmed cell death in aging (2015) · cites this paper as Herndon et al., 2002

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Authors: Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M.
Affiliations: Rutgers, The State University of New Jersey (US)
Albert Einstein College of Medicine (US)
Corresponding author: Hall, David H.
Driscoll, Monica
ORCID: Hall, David H.
Driscoll, Monica
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 2002-10
Volume: 419
Issue: 6909
Pages: 808-814
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/nature01135
OpenAlex: W2034734284
Cited by: 1,214
References: 52
Citations by year: 2026: 40 · 2025: 49 · 2024: 65 · 2023: 39 · 2022: 63 · 2021: 65 · 2020: 68 · 2019: 61 · 2018: 60 · 2017: 57 · 2016: 69 · 2015: 51 · 2014: 54 · 2013: 77 · 2012: 48
FWCI: 9.31
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
Funders: National Institutes of Health (R24OD010943)
National Center for Research Resources (R24RR012596)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
Keywords: Caenorhabditis elegans, aging, lifespan extension, sarcopenia, muscle degeneration, ultrastructure, interindividual variability, cell-to-cell variability
MeSH terms: Aging, Animals, Gene Expression Regulation, Humans, Locomotion, Longevity, Muscles, Mutation, Nervous System Physiological Phenomena, Neurons, Organ Specificity, Phenotype, Reproduction, Stochastic Processes, Time Factors, Biomarkers, Cellular Senescence, Caenorhabditis elegans, Genes, Helminth, Phosphatidylinositol 3-Kinases, Caenorhabditis elegans Proteins

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