A general synthesis of dirhodium metallopeptides as MDM2 ligands
Abstract
A synthesis of multifunctional dirhodium metallopeptide ligands for MDM2 is presented. An orthogonal protection scheme of palladium-catalyzed de-allylation on a metallopeptide substrate allows specific dirhodium incorporation in a complex peptide. Sequence effects on MDM2 binding are discussed.
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- Authors
- Zaykov, A. N., & Ball, Z. T.
- Affiliations
- Rice University (US)
- Corresponding author
- Ball, Zachary T.
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 47
- Issue
- 39
- Pages
- 10927
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2056995087
- Cited by
- 27
- References
- 46
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 2 · 2013: 1 · 2012: 5
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chemical Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chemical Synthesis and Analysis
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- orthogonal protection, peptide sequence effects, metal-peptide complexes
- MeSH terms
- Amino Acid Sequence, Ligands, Models, Molecular, Molecular Sequence Data, Peptides, Rhodium, Molecular Probes, Protein Structure, Tertiary, Proto-Oncogene Proteins c-mdm2
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