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Azobenzene photoswitches for biomolecules
Abstract
The photoisomerization of azobenzene has been known for almost 75 years but only recently has this process been widely applied to biological systems. The central challenge of how to productively couple the isomerization process to a large functional change in a biomolecule has been met in a number of instances and it appears that effective photocontrol of a large variety of biomolecules may be possible. This critical review summarizes key properties of azobenzene that enable its use as a photoswitch in biological systems and describes strategies for using azobenzene photoswitches to drive functional changes in peptides, proteins, nucleic acids, lipids, and carbohydrates (192 references).
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Cites
Optogenetic dissection of a behavioural module in the vertebrate spinal cord
Wyart, C., Bene, F. D., Warp, E., Scott, E. K., Trauner, D., Baier, H., & Isacoff, E. Y. (2009) · Nature · doi:10.1038/nature08323 · Cited by 409
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Visible‐Light‐Activated Molecular Switches
Bléger, D., & Hecht, S. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201500628 · Cited by 853
Azobenzene-based solar thermal fuels: design, properties, and applications
Dong, L., Feng, Y., Wang, L., & Feng, W. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00470f · Cited by 474
ortho‐Fluoroazobenzenes: Visible Light Switches with Very Long‐Lived Z Isomers
Knie, C., Utecht, M., Zhao, F., Kulla, H., Kovalenko, S., Brouwer, A. M., Saalfrank, P., Hecht, S., & Bléger, D. (2014) · Chemistry – A European Journal · doi:10.1002/chem.201404649 · Cited by 438
Recent developments in reversible photoregulation of oligonucleotide structure and function
Lubbe, A. S., Szymanski, W., & Feringa, B. L. (2017) · Chemical Society Reviews · doi:10.1039/c6cs00461j · Cited by 336
Triplex DNA Nanostructures: From Basic Properties to Applications
Hu, Y., Cecconello, A., Idili, A., Ricci, F., & Willner, I. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201701868 · Cited by 336
Metadata
- Authors
- Beharry, A. A., & Woolley, G. A.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 40
- Issue
- 8
- Pages
- 4422
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2011393168
- Cited by
- 1,851
- References
- 1
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
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