The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Injectable and biodegradable hydrogels: gelation, biodegradation and biomedical applications
Abstract
Injectable hydrogels with biodegradability have in situ formability which in vitro/in vivo allows an effective and homogeneous encapsulation of drugs/cells, and convenient in vivo surgical operation in a minimally invasive way, causing smaller scar size and less pain for patients. Therefore, they have found a variety of biomedical applications, such as drug delivery, cell encapsulation, and tissue engineering. This critical review systematically summarizes the recent progresses on biodegradable and injectable hydrogels fabricated from natural polymers (chitosan, hyaluronic acid, alginates, gelatin, heparin, chondroitin sulfate, etc.) and biodegradable synthetic polymers (polypeptides, polyesters, polyphosphazenes, etc.). The review includes the novel naturally based hydrogels with high potential for biomedical applications developed in the past five years which integrate the excellent biocompatibility of natural polymers/synthetic polypeptides with structural controllability via chemical modification. The gelation and biodegradation which are two key factors to affect the cell fate or drug delivery are highlighted. A brief outlook on the future of injectable and biodegradable hydrogels is also presented (326 references).
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Cites
Matrix elasticity directs stem cell lineage specification
Engler, A. J., Sen, S., Sweeney, H. L., & Discher, D. E. (2006) · Cell · doi:10.1016/j.cell.2006.06.044 · Cited by 13,915
Hydrogels for tissue engineering: scaffold design variables and applications
Drury, J. L., & Mooney, D. J. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00340-5 · Cited by 5,136
Hydrogels for biomedical applications
Hoffman, A. S. (2002) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00239-3 · Cited by 4,864
Lutolf, M. P., & Hubbell, J. A. (2005) · Nature Biotechnology · doi:10.1038/nbt1055 · Cited by 4,551
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan—a review
George, M., & Abraham, T. E. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.017 · Cited by 2,012
Drug targeting using thermally responsive polymers and local hyperthermia
Meyer, D. E., Shin, B. C., Kong, G. A., Dewhirst, M. W., & Chilkoti, A. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(01)00319-4 · Cited by 416
Galler, K. M., Aulisa, L., Regan, K. R., D’Souza, R. N., & Hartgerink, J. D. (2010) · Journal of the American Chemical Society · doi:10.1021/ja910481t · Cited by 339
Jay, S. M., Shepherd, B. R., Andrejecsk, J. W., Kyriakides, T. R., Pober, J. S., & Saltzman, W. M. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2010.01.014 · Cited by 85
Cited by
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070
25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Annabi, N., Tamayol, A., Uquillas, J. A., Akbari, M., Bertassoni, L. E., Cha, C., Camci‐Unal, G., Dokmeci, M. R., Peppas, N. A., & Khademhosseini, A. (2014) · Advanced Materials · doi:10.1002/adma.201303233 · Cited by 1,409
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Huang, G., Li, F., Zhao, X., Ma, Y., Li, Y., Lin, M., Jin, G., Lu, T. J., Genin, G. M., & Xu, F. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00094 · Cited by 825
Self-citationEnzyme-responsive polymeric assemblies, nanoparticles and hydrogels
Hu, J., Zhang, G., & Liu, S. (2012) · Chemical Society Reviews · doi:10.1039/c2cs35103j · Cited by 722
Designing degradable hydrogels for orthogonal control of cell microenvironments
Kharkar, P. M., Kiick, K. L., & Kloxin, A. M. (2013) · Chem. Soc. Rev. · doi:10.1039/c3cs60040h · Cited by 717
Metadata
- Authors
- Li, Y., Rodrigues, J., & Tomás, H.
- Venue
- Chem. Soc. Rev.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 41
- Issue
- 6
- Pages
- 2193-2221
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2048893610
- Cited by
- 1,445
- References
- 8
- FWCI
- 3.17
- Type
- journal article
- Language
- en
- Open access
- closed
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