Spatially organized in vitro models instruct asymmetric stem cell differentiation

Matrix elasticity directs stem cell lineage specification

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Cell Shape, Cytoskeletal Tension, and RhoA Regulate Stem Cell Lineage Commitment

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New cell lines from mouse epiblast share defining features with human embryonic stem cells

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BMP Induction of Id Proteins Suppresses Differentiation and Sustains Embryonic Stem Cell Self-Renewal in Collaboration with STAT3

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Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture

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Promotion of Trophoblast Stem Cell Proliferation by FGF4

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Surface engineering approaches to micropattern surfaces for cell-based assays

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Embryonic Stem Cells: Prospects for Developmental Biology and Cell Therapy

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Axis Development and Early Asymmetry in Mammals

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Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse

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Detection of functional haematopoietic stem cell niche using real-time imaging

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Nodal signalling in the epiblast patterns the early mouse embryo

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lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal

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Cripto is required for correct orientation of the anterior–posterior axis in the mouse embryo

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Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

ten Berge, D., Koole, W., Fuerer, C., Fish, M., Eroglu, E., & Nusse, R. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.09.013 · Cited by 477 · see citing works

Control of Human Embryonic Stem Cell Colony and Aggregate Size Heterogeneity Influences Differentiation Trajectories

Bauwens, C. L., Peerani, R., Niebruegge, S., Woodhouse, K. A., Kumacheva, E., Husain, M., & Zandstra, P. W. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0183 · Cited by 442 · see citing works

BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways

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Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts

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Niche‐mediated control of human embryonic stem cell self‐renewal and differentiation

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Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo

Morris, S. A., Teo, R., Li, H., Robson, P., Glover, D. M., & Zernicka‐Goetz, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915063107 · Cited by 309 · see citing works

Heterogeneity of Embryonic and Adult Stem Cells

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Primitive streak formation in mice is preceded by localized activation of Brachyury and Wnt3

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Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans

Dupuy, D., Bertin, N., Hidalgo, C. A., Venkatesan, K., Tu, D. K., Lee, D., Rosenberg, J., Svrzikapa, N., Blanc, A., Carnec, A., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1305 · Cited by 286 · see citing works

Lineage choice and differentiation in mouse embryos and embryonic stem cells

Loebel, D. A. F., Watson, C. M., Young, R. A. D., & Tam, P. (2003) · Developmental Biology · doi:10.1016/s0012-1606(03)00390-7 · Cited by 245 · see citing works

Printing Cells

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Combinatorial Signaling Microenvironments for Studying Stem Cell Fate

Flaim, C. J., Teng, D., Chien, S., & Bhatia, S. N. (2008) · Stem Cells and Development · doi:10.1089/scd.2007.0085 · Cited by 195 · see citing works

Cell patterning chip for controlling the stem cell microenvironment

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Induction and migration of the anterior visceral endoderm is regulated by the extra-embryonic ectoderm

Rodríguez, T. A., Srinivas, S., Clements, M., Smith, J. C., & Beddington, R. S. P. (2005) · Development · doi:10.1242/dev.01847 · Cited by 154 · see citing works

Polymeric Aqueous Biphasic Systems for Non‐Contact Cell Printing on Cells: Engineering Heterocellular Embryonic Stem Cell Niches

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Embryonic stem-cell culture as a tool for developmental cell biology

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Patterning multiple cell types in co-cultures: A review

Goubko, C. A., & Cao, X. (2009) · Materials Science and Engineering C · doi:10.1016/j.msec.2009.02.016 · Cited by 105 · see citing works

Micropatterned Environments in Cell Biology

Raghavan, S., & Chen, C. S. (2004) · Advanced Materials · doi:10.1002/adma.200400594 · Cited by 103 · see citing works

Embryonic Stem Cell-Derived Embryoid Bodies: An In Vitro Model of Eutherian Pregastrulation Development and Early Gastrulation

Weitzer, G. (2006) · Handbook of experimental pharmacology · doi:10.1007/3-540-31265-x_2 · Cited by 66 · see citing works

Spatial Organization of Embryonic Stem Cell Responsiveness to Autocrine Gp130 Ligands Reveals an Autoregulatory Stem Cell Niche

Davey, R. E., & Zandstra, P. W. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0216 · Cited by 62 · see citing works

Characterization of Gastrulation‐Stage Progenitor Cells and Their Inhibitory Crosstalk in Human Embryoid Bodies

Kopper, O., Giladi, O., Golan-lev, T., & Benvenisty, N. (2009) · Stem Cells · doi:10.1002/stem.260 · Cited by 33 · see citing works

Organoids

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Probing Embryonic Stem Cell Autocrine and Paracrine Signaling Using Microfluidics

Joel Voldman, B., & Przybyla, L. (2012) · DSpace@MIT (Massachusetts Institute of Technology) · Cited by 71 · see citing works

Bioprinting of Cells, Organoids and Organs-on-a-Chip Together with Hydrogels Improves Structural and Mechanical Cues

Mierke, C. T. (2024) · Cells · doi:10.3390/cells13191638 · Cited by 54 · see citing works

Emerging strategies for spatiotemporal control of stem cell fate and morphogenesis

Kinney, M. A., & McDevitt, T. C. (2012) · Trends in biotechnology · doi:10.1016/j.tibtech.2012.11.001 · Cited by 53 · see citing works

Controlling Spatial Organization of Multiple Cell Types in Defined 3D Geometries

Tekin, H., Sanchez, J. G., Landeros, C., Dubbin, K., Langer, R., & Khademhosseini, A. (2012) · Advanced Materials · doi:10.1002/adma.201201805 · Cited by 48 · see citing works

Microfluidic-based patterning of embryonic stem cells for in vitro development studies

Suri, S., Singh, A. K., Anh, N. T. V., Bratt‐Leal, A. M., McDevitt, T. C., & Lu, H. (2013) · Lab on a Chip · doi:10.1039/c3lc50663k · Cited by 40 · see citing works

In vitro testicular toxicity models: Opportunities for advancement via biomedical engineering techniques

Parks, L. G. (2013) · ALTEX · doi:10.14573/altex.2013.3.353 · Cited by 39 · see citing works

A method for human teratogen detection by geometrically confined cell differentiation and migration

Xing, J., Toh, Y., Xu, S., & Yu, H. (2015) · Scientific Reports · doi:10.1038/srep10038 · Cited by 34 · see citing works

Pluripotent stem cells as a model for embryonic patterning: From signaling dynamics to spatial organization in a dish

Heemskerk, I., & Warmflash, A. (2016) · Developmental Dynamics · doi:10.1002/dvdy.24432 · Cited by 33 · see citing works

The development of cell-initiated degradable hydrogel based on methacrylated alginate applicable to multiple microfabrication technologies

Sun, J., Wei, D., Yang, K., Yang, Y., Liu, X., Fan, H., & Zhang, X. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb01458a · Cited by 33 · see citing works

Microfluidic devices for stem cell analysis

Kang, D.-K., Lu, J., Kang, D.-K., Lu, J., Zhang, W., Chang, E., Eckert, M. A., Ali, M. M., & Zhao, W. (2013) · Elsevier eBooks · doi:10.1533/9780857097040.3.388 · Cited by 6 · see citing works

Probing Embryonic Stem Cell Autocrine and Paracrine Signaling Using Microfluidics

Przybyla, L., & Joel Voldman, B. (2012) · Annual Review of Analytical Chemistry · doi:10.1146/annurev-anchem-062011-143122 · Cited by 2 · see citing works

Microfluidic devices for stem cell analysis

Kang, D.-K., Lu, J., Zhang, W., Chang, E., Eckert, M. A., Ali, M. M., Zhao, W., & Li, X. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819971-8.00013-5 · Cited by 2 · see citing works

The cell-secreted microenvironment : shaping embryonic stem cell self-renewal and differentiation

Przybyla, L. (2012) · DSpace@MIT (Massachusetts Institute of Technology)

Stem cells in microfluidics: control on soluble microenvironment

Chowdhury, M. M., Kawada, J., Fujii, T., & Sakai, Y. (2012) · 生産研究 · doi:10.11188/seisankenkyu.64.323

Research highlights

Selimović, Š., Dokmeci, M. R., & Khademhosseini, A. (2012) · Lab on a Chip · doi:10.1039/c2lc90017c

Cartilage repair: unleashing PRP’s potential in organoid models

Golshan, M., Dortaj, H., Omidi, Z., Golshan, M., Pourentezari, M., Rajabi, M., & Rajabi, A. (2025) · Cytotechnology · doi:10.1007/s10616-025-00739-1

Differential environmental spatial patterning (dESP) recreates proximal-distal axial pattrens in embryonic stem cell colonies

Toh, Y., Blagović, K., Yu, H., & Joel Voldman, B. (2011)

Differential environmental spatial patterning (δESP) recreates proximal-distal axial pattrens in embryonic stem cell colonies

Toh, Y., Blagović, K., Yu, H., & Joel Voldman, B. (2011) · National University of Singapore

Spatially Organized Differentiation of Mouse Pluripotent Stem Cells on Micropatterned Surfaces

Morgani, S. M., & Hadjantonakis, A. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0958-3_4 · Cited by 5 · see citing works

Controlled Organization of Cell Fates in Spatially Confined Stem Cell Populations

Östblom, J. (2020) · TSpace (University of Toronto)

Micropatterning for spatially confined differentiation of embryonic stem cells

Hoekstra, F. (2016) · Leiden Repository (Leiden University)