The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
LC-MS-based metabolomics
Open accessAbstract
Metabolomics aims at identification and quantitation of small molecules involved in metabolic reactions. LC-MS has enjoyed a growing popularity as the platform for metabolomic studies due to its high throughput, soft ionization, and good coverage of metabolites. The success of a LC-MS-based metabolomic study often depends on multiple experimental, analytical, and computational steps. This review presents a workflow of a typical LC-MS-based metabolomic analysis for identification and quantitation of metabolites indicative of biological/environmental perturbations. Challenges and current solutions in each step of the workflow are reviewed. The review intends to help investigators understand the challenges in metabolomic studies and to determine appropriate experimental, analytical, and computational methods to address these challenges.
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HMDB: the Human Metabolome Database
Wishart, D. S., Tzur, D., Knox, C., Eisner, R., Guo, A. C., Young, N., Cheng, D., Jewell, K., Arndt, D., Sawhney, S., et al. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl923 · Cited by 3,231
Metabolomics — the link between genotypes and phenotypes
Fiehn, O. (2002) · Functional Genomics · doi:10.1007/978-94-010-0448-0_11 · Cited by 3,167
MassBank: a public repository for sharing mass spectral data for life sciences
Horai, H., Arita, M., Kanaya, S., Nihei, Y., Ikeda, T., Suwa, K., Ojima, Y., Tanaka, K., Tanaka, S., Aoshima, K., et al. (2010) · Journal of Mass Spectrometry · doi:10.1002/jms.1777 · Cited by 2,529
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Mass spectrometry‐based metabolomics
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Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
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Using machine learning approaches for multi-omics data analysis: A review
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Integration of GC–MS and LC–MS for untargeted metabolomics profiling
Zeki, Ö. C., Eylem, C. C., Reçber, T., Kır, S., & Nemutlu, E. (2020) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2020.113509 · Cited by 336
Application of Metabolomics in Alzheimer’s Disease
Wilkins, J. M., & Trushina, E. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2017.00719 · Cited by 268
Metabolomic analysis in inflammatory bowel disease: A systematic review
Gallagher, K., Catesson, A., Griffin, J. L., Holmes, E., & Williams, H. R. T. (2021) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjaa227 · Cited by 133
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Metadata
- Authors
- Zhou, B., Xiao, J. F., Tuli, L., & Ressom, H. W.
- Venue
- Molecular BioSystems
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-11-01
- Volume
- 8
- Issue
- 2
- Pages
- 470-481
- ISSN
- 1742-2051 (ISSN-L)
- 1742-206X
- OpenAlex
- W2032555174
- Cited by
- 639
- References
- 80
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhou, B., Xiao, J. F., Tuli, L., & Ressom, H. W. (2011). LC-MS-based metabolomics. Molecular BioSystems. https://doi.org/10.1039/c1mb05350g
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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