The DOI matches its Crossref record; 63 of the 63 references it cites were found in a registry or an index.
Anticancer compounds derived from fungal endophytes: their importance and future challenges
Abstract
Covering: 1990 to 2010 This is a review of anticancer agents isolated from endophytic fungi from 1990–2010. Endophytic fungi are defined as fungi that live asymptomatically within the tissues of higher plants. The designation ‘anticancer’ is based on the assessment of the authors of the paper of the cytotoxicity of each compound against specific cancer cell lines. Many of the compounds reported here were isolated exclusively from endophytes in culture, while other compounds had been previously reported as chemical constituents of higher plants. The uniqueness of the endophytic community of fungi is stressed as a promising source of novel compounds with anticancer activity, or as an alternative source of compounds originally isolated from higher plants. Endophytes represent a dependable source of specific secondary metabolites, and can be manipulated both physicochemically and genetically to increase yields of desired metabolites and to produce novel analogues of active metabolites.
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Cites
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HSP90 and the chaperoning of cancer
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Plants as a source of anti-cancer agents
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Self-citationNatural Products in Drug Discovery and Development
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Cited by
Chemical Ecology of Endophytic Fungi: Origins of Secondary Metabolites
Kusari, S., Hertweck, C., & Spiteller, M. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.06.004 · Cited by 743
Endophytic fungi from medicinal plants: a treasure hunt for bioactive metabolites
Kaul, S., Gupta, S., Ahmed, M., & Dhar, M. K. (2012) · Phytochemistry Reviews · doi:10.1007/s11101-012-9260-6 · Cited by 370
A critical review on exploiting the pharmaceutical potential of plant endophytic fungi
Gupta, S., Chaturvedi, P., Kulkarni, M. G., & Van Staden, J. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.107462 · Cited by 346
Vig, R., Bhadra, F., Gupta, S. K., Sairam, K., & Vasundhara, M. (2022) · Journal of Applied Microbiology · doi:10.1111/jam.15174 · Cited by 40
Metadata
- Authors
- Kharwar, R. N., Mishra, A., Gond, S. K., Stierle, A., & Stierle, D.
- Venue
- Natural Product Reports
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 28
- Issue
- 7
- Pages
- 1208
- ISSN
- 0265-0568 (ISSN-L)
- 1460-4752
- OpenAlex
- W2045265255
- Cited by
- 530
- References
- 63
- FWCI
- 21.91
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
