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Controlled drug release characteristics and enhanced antibacterial effect of graphene nanosheets containing gentamicin sulfate
Abstract
A novel methanol derived graphene (MDG) and gentamicin sulfate nanohybrid was prepared, and the loading and release behaviour of gentamicin on MDG is investigated. An efficient drug loading of 2.57 mg mg(-1) was obtained at pH 7. By applying release kinetic models, the mechanism of release of the drug from the MDG matrix was found to be following the Korsmeyer-Peppas model. However, the diffusional release exponent (n) value lies below 0.5 demonstrating that the mechanism controlling the drug release is the Fickian diffusion.
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Citations
Cited by
New Horizons for Diagnostics and Therapeutic Applications of Graphene and Graphene Oxide
Feng, L., Wu, L., & Qu, X. (2013) · Advanced Materials · doi:10.1002/adma.201203229 · Cited by 632
Graphene-based materials biocompatibility: A review
Pinto, A. M., Gonçalves, I. C., & Magalhães, F. D. (2013) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2013.05.022 · Cited by 566
Antibacterial Properties of Graphene-Based Nanomaterials
Kumar, P., Huo, P., Zhang, R., & Liu, B. (2019) · Nanomaterials · doi:10.3390/nano9050737 · Cited by 512
Salamanca, C. H., Barrera-Ocampo, A., Lasso, J. C., Camacho, N., & Yarce, C. J. (2018) · Pharmaceutics · doi:10.3390/pharmaceutics10030148 · Cited by 188
Metadata
- Authors
- Pandey, H., Parashar, V., Parashar, R., Prakash, R., Ramteke, P. W., & Pandey, A. C.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 3
- Issue
- 10
- Pages
- 4104
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2038695670
- Cited by
- 161
- References
- 0
- FWCI
- 5.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pandey, H., Parashar, V., Parashar, R., Prakash, R., Ramteke, P. W., & Pandey, A. C. (2011). Controlled drug release characteristics and enhanced antibacterial effect of graphene nanosheets containing gentamicin sulfate. Nanoscale. https://doi.org/10.1039/c1nr10661a
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