Franz diffusion cell approach for pre-formulation characterisation of ketoprofen semi-solid dosage forms
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This study aimed to evaluate and compare, using the methodology of Franz diffusion cells, the ketoprofen (KTP) releasing profiles of two formulations: A gel and a conventional suspension. The second aim was to show that this methodology might be easily applied for the development of semi-solid prototypes and claim proof in pre-formulation stages. Drug release analysis was carried out under physiological conditions (pH: 5.6 to 7.4; ionic strength 0.15 M; at 37 °C) for 24 h. Three independent vertical Franz cells were used with a nominal volume of the acceptor compartment of 125 mL and a diffusion area of 2.5 cm2. Additionally, two different membranes were evaluated: A generic type (regenerated cellulose) and a transdermal simulation type (Strat-M®). The KTP permeation profiles demonstrated that depending on the membrane type and the vehicle used, the permeation is strongly affected. High permeation efficiencies were obtained for the gel formulation, and the opposite effect was observed for the suspension formulation. Moreover, the permeation studies using Strat-M membranes represent a reproducible methodology, which is easy to implement for pre-formulation stage or performance evaluation of semi-solid pharmaceutical products for topical or transdermal administration.
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A positive correlation was observed for total permeated phenoxyethanol between skin PAMPA and porcine or human skin in a Franz diffusion cell.
“notably, the authors observed a positive correlation for the total amount of permeated phenoxyethanol between this artificial membrane and porcine or human skin placed in a Franz diffusion cell, a widely used system to test drug permeation in vitro [16,17,18].”
From Recreating Human Skin In Vitro: Should the Microbiota Be Taken into Account? (2024) · cites this paper as [18]
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- Authors
- Salamanca, C. H., Barrera-Ocampo, A., Lasso, J. C., Camacho, N., & Yarce, C. J.
- Affiliations
- Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Naturales, Universidad Icesi, Calle 18 No. 122-135, Cali 760031, Colombia
- Universidad Icesi (CO)
- Corresponding author
- Yarce, Cristhian J.
- Venue
- Pharmaceutics
- Publisher
- MDPI AG
- Published
- 2018-09-05
- Volume
- 10
- Issue
- 3
- Pages
- 148
- ISSN
- 1999-4923 (ISSN-L)
- PMC
- PMC6161298
- OpenAlex
- W2890854556
- Cited by
- 188
- References
- 39
- Citations by year
- 2026: 27 · 2025: 27 · 2024: 28 · 2023: 28 · 2022: 29 · 2021: 27 · 2020: 15 · 2019: 6 · 2018: 1
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Pharmaceutics (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Universidad ICESI (041312)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Keywords
- ketoprofen, Franz diffusion cell, semisolid dosage forms, topical drug delivery, gel formulation, suspension formulation, preformulation, drug release profile, regenerated cellulose membrane
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