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One-step preparation of reduction-responsive poly(ethylene glycol)-poly(amino acid)s nanogels as efficient intracellular drug delivery platforms
Abstract
A series of disulfide-core-cross-linked poly(ethylene glycol)-poly(amino acid)s star copolymers were synthesized through one-step ring-opening polymerization of L-phenylalanine N-carboxyanhydride (L-Phe NCA) and L-cystine N-carboxyanhydride (L-Cys NCA) with amino group terminated poly(ethylene glycol) monomethyl ether (mPEG-NH2) as macroinitiator. The reduction-responsive PEG-poly(amino acid)s nanogels (NGs) were prepared by directly dispersing the resultant PEG-poly(amino acid)s in phosphate buffer solution at pH 7.4. Dynamic light scattering (DLS) measurements showed that the reducible NG swelled in response to 10 mM glutathione (GSH). Doxorubicin (DOX), an anthracycline anticancer drug, was loaded into the NGs. The in vitro release results revealed that the release behaviors could be adjusted by GSH concentration, and poly(amino acid)s content and composition. The intracellular DOX release results showed that enhanced intracellular DOX release occurred in GSH pretreated Henrietta Lacks (HeLa) cells. In vitro methyl thiazolyl tetrazolium (MTT) assays indicated that the NGs were biocompatible, and DOX-loaded NG showed higher cellular proliferation inhibition towards GSH pretreated HeLa cells than that of non-pretreated cells. Therefore, the NGs can efficiently deliver anticancer drugs into tumor cells and inhibit cell proliferation, rendering highly promising for targeted intracellular delivery of operative chemotherapeutic drugs in cancer therapy.
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Drug target identification using side-effect similarity
Campillos, M., Kuhn, M., Gavin, A.-C., Jensen, L. J., & Bork, P. (2008) · Science · doi:10.1126/science.1158140 · Cited by 1,248
Thermo and pH Dual‐Responsive Nanoparticles for Anti‐Cancer Drug Delivery
Zhang, L., Guo, R., Yang, M., Jiang, X., & Liu, B. (2007) · Advanced Materials · doi:10.1002/adma.200601817 · Cited by 269
Folate-decorated nanogels for targeted therapy of ovarian cancer
Nukolova, N. V., Oberoi, H. S., Cohen, S. M., Kabanov, A. V., & Bronich, T. K. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.04.006 · Cited by 223
Kluza, E., Yeo, S. Y., Schmid, S., van der Schaft, D. W. J., Boekhoven, R. W., Schiffelers, R. M., Storm, G., Strijkers, G. J., & Nicolay, K. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.11.031 · Cited by 54
Cited by
Ge, Z., & Liu, S. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60048c · Cited by 914
Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery
Li, Y., Maciel, D., Rodrigues, J., Shi, X., & Tomás, H. (2015) · Chemical Reviews · doi:10.1021/cr500131f · Cited by 478
Deng, C., Wu, J., Cheng, R., Meng, F., Klok, H.-A., & Zhong, Z. (2014) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2013.10.008 · Cited by 371
Polymeric nanostructured materials for biomedical applications
Tang, Z., He, C., Tian, H., Ding, J., Hsiao, B. S., Chu, B., & Chen, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.05.005 · Cited by 363
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Metadata
- Authors
- Ding, J., Shi, F., Xiao, C., Lin, L., Chen, L., He, C., Zhuang, X., & Chen, X.
- Venue
- Polymer Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2011
- Volume
- 2
- Issue
- 12
- Pages
- 2857
- ISSN
- 1759-9954 (ISSN-L)
- 1759-9962
- OpenAlex
- W2138034502
- Cited by
- 228
- References
- 4
- FWCI
- 9.14
- Type
- journal article
- Language
- en
- Open access
- closed
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