Thermo and pH Dual‐Responsive Nanoparticles for Anti‐Cancer Drug Delivery
Abstract
Thermo and pH dual-responsive nanoparticles encapsulating an anti-cancer drug (paclitaxel) were assembled from a diblock copolymer comprised of a hydrophilic poly(N-isopropylacrylamide-co-acrylic acid) block and a hydrophobic polycaprolactone block. These nanoparticles aggregated at body temperature under a slightly acidic pH of 6.9 (see figure), and a faster drug release was found to be associated with higher temperature and lower pH, both of which are advantageous for tumor-targeted anti-caner drug delivery.
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These findings indicated that nanocarriers would accumulate and release the drug selectively in cancer cell tissues to achieve targeted delivery of anticancer drugs.
“These findings indicated that nanocarriers would accumulate and release the drug selectively in cancer cell tissues to achieve targeted delivery of anticancer drugs [114].”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [114]
In another study, a dual responsive biocompatible nanocarrier had a size of ~100-230 nm and an encapsulation efficiency of 98%.
“The authors determined the size of the prepared nanocarrier and the encapsulation efficiency to be ~100–230 nm and 98%, respectively.”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [114]
The nanocarrier formed aggregates under slightly acidic pH (pH 6.9).
“It was found that nanocarrier formed aggregates under slightly acidic pH (pH 6.9).”
From Recent Advances in Nanomicelles Delivery Systems. (2020) · cites this paper as [114]
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- Authors
- Zhang, L., Guo, R., Yang, M., Jiang, X., & Liu, B.
- Affiliations
- Nanjing University (CN)
- Nanjing Drum Tower Hospital (CN)
- Venue
- Advanced Materials
- Publisher
- Wiley
- Published
- 2007-09-05
- Volume
- 19
- Issue
- 19
- Pages
- 2988-2992
- ISSN
- 0935-9648 (ISSN-L)
- 1521-4095
- OpenAlex
- W1986120998
- Cited by
- 269
- References
- 23
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 6 · 2023: 7 · 2022: 11 · 2021: 11 · 2020: 13 · 2019: 20 · 2018: 20 · 2017: 21 · 2016: 22 · 2015: 16 · 2014: 25 · 2013: 21 · 2012: 13
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Materials (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- pH-responsive nanoparticles, dual-responsive drug delivery, paclitaxel, poly(N-isopropylacrylamide-co-acrylic acid), polycaprolactone, diblock copolymers, anticancer drug delivery, stimuli-responsive drug release, nanoparticle aggregation
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