The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Diversity-oriented synthesis: producing chemical tools for dissecting biology
Abstract
Small molecule modulators of biological function can be discovered by the screening of compound libraries. However, it became apparent that some human disease related targets could not be addressed by the libraries commonly used which typically are comprised of large numbers of structurally similar compounds. The last decade has seen a paradigm shift in library construction, with particular emphasis now being placed on increasing a library's structural, and thus functional diversity, rather than only its size. Diversity-oriented synthesis (DOS) aims to generate such structural diversity efficiently. This tutorial review has been written to introduce the subject to a broad audience and recent achievements in both the preparation and the screening of structurally diverse compound collections against so-called 'undruggable' targets are highlighted.
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Cites
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Schneider, G. (2018) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.232 · Cited by 910
Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates
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Stereodivergence in Asymmetric Catalysis
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Modulators of Protein–Protein Interactions
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Metadata
- Authors
- O' Connor, C. J., Beckmann, H. S. G., & Spring, D. R.
- Venue
- Chemical Society Reviews
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 41
- Issue
- 12
- Pages
- 4444
- ISSN
- 0306-0012 (ISSN-L)
- 1460-4744
- OpenAlex
- W2118865435
- Cited by
- 434
- References
- 88
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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