Natural products as sources of new drugs over the last 25 years
Abstract
This review is an updated and expanded version of two prior reviews that were published in this journal in 1997 and 2003. In the case of all approved agents the time frame has been extended to include the 251/2 years from 01/1981 to 06/2006 for all diseases worldwide and from 1950 (earliest so far identified) to 06/2006 for all approved antitumor drugs worldwide. We have continued to utilize our secondary subdivision of a "natural product mimic" or "NM" to join the original primary divisions. From the data presented, the utility of natural products as sources of novel structures, but not necessarily the final drug entity, is still alive and well. Thus, in the area of cancer, over the time frame from around the 1940s to date, of the 155 small molecules, 73% are other than "S" (synthetic), with 47% actually being either natural products or directly derived therefrom. In other areas, the influence of natural product structures is quite marked, with, as expected from prior information, the antiinfective area being dependent on natural products and their structures. Although combinatorial chemistry techniques have succeeded as methods of optimizing structures and have, in fact, been used in the optimization of many recently approved agents, we are able to identify only one de novo combinatorial compound approved as a drug in this 25 plus year time frame. We wish to draw the attention of readers to the rapidly evolving recognition that a significant number of natural product drugs/leads are actually produced by microbes and/or microbial interactions with the "host from whence it was isolated", and therefore we consider that this area of natural product research should be expanded significantly.
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The bio-active molecules impact has been evaluated against various cancer types in clinical trials.
“The bio-active molecules impact has been evaluated against various cancer types in clinical trials [41,42,43,44,45].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [45]
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- Authors
- Newman, D. J., & Cragg, G. M.
- Affiliations
- National Cancer Institute (US)
- Corresponding author
- Newman, David J.
- Venue
- Journal of Natural Products
- Publisher
- American Chemical Society (ACS)
- Published
- 2007-02-20
- Volume
- 70
- Issue
- 3
- Pages
- 461-477
- ISSN
- 0163-3864 (ISSN-L)
- 1520-6025
- OpenAlex
- W2141474275
- Cited by
- 5,517
- References
- 53
- Citations by year
- 2026: 82 · 2025: 101 · 2024: 138 · 2023: 152 · 2022: 180 · 2021: 226 · 2020: 277 · 2019: 265 · 2018: 264 · 2017: 334 · 2016: 410 · 2015: 496 · 2014: 520 · 2013: 448 · 2012: 483
- FWCI
- 26.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Natural Products (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- natural products, drug discovery, approved drugs, anticancer agents, combinatorial chemistry, microbial natural products, host-microbe interactions, drug leads
- MeSH terms
- Biological Products, Pharmacology, Research, Molecular Structure, Drug Approval, Combinatorial Chemistry Techniques, History, 20th Century, History, 21st Century
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