The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition
Abstract
Recent studies reveal that long non-coding RNAs (lncRNAs) have been shown to have important regulatory roles in cancer biology, and lncRNA MALAT-1 expression is upregulated in some tumors. However, the contributions of MALAT-1 to bladder cancer metastasis remain largely unknown. In the present study we evaluated MALAT-1 expression in bladder cancer tissues by real-time PCR, and defined its biological functions. We verified that MALAT-1 levels were upregulated in bladder cancer tissues compared with adjacent normal tissues, and MALAT-1 expression was remarkably increased in primary tumors that subsequently metastasized, when compared to those primary tumors that did not metastasize. SiRNA-mediated MALAT-1 silencing impaired in vitro bladder cancer cell migration. Downregulation of MALAT-1 resulted in a decrease of the epithelial–mesenchymal transition (EMT)-associated ZEB1, ZEB2 and Slug levels, and an increase of E-cadherin levels. We further demonstrated that MALAT-1 promoted EMT by activating Wnt signaling in vitro. These data suggest an important role for MALAT-1 in regulating metastasis of bladder cancer and the potential application of MALAT-1 in bladder cancer therapy.
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Cited by
MALAT1 — a paradigm for long noncoding RNA function in cancer
Gutschner, T., Hämmerle, M., & Diederichs, S. (2013) · Journal of Molecular Medicine · doi:10.1007/s00109-013-1028-y · Cited by 719
Long Noncoding RNA in Prostate, Bladder, and Kidney Cancer
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Long non-coding RNAs and complex diseases: from experimental results to computational models
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Metadata
- Authors
- Ying, L., Chen, Q., Wang, Y., Zhou, Z., Huang, Y., & Qiu, F.
- Venue
- Molecular BioSystems
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-05-17
- Volume
- 8
- Issue
- 9
- Pages
- 2289-2294
- ISSN
- 1742-2051 (ISSN-L)
- 1742-206X
- OpenAlex
- W2124198704
- Cited by
- 344
- References
- 28
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ying, L., Chen, Q., Wang, Y., Zhou, Z., Huang, Y., & Qiu, F. (2012). Upregulated MALAT-1 contributes to bladder cancer cell migration by inducing epithelial-to-mesenchymal transition. Molecular BioSystems. https://doi.org/10.1039/c2mb25070e
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