The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
A Wnt–Axin2–GSK3β cascade regulates Snail1 activity in breast cancer cells
Open accessAbstract
Accumulating evidence indicates that hyperactive Wnt signalling occurs in association with the development and progression of human breast cancer. As a consequence of engaging the canonical Wnt pathway, a β-catenin–T-cell factor (TCF) transcriptional complex is generated, which has been postulated to trigger the epithelial–mesenchymal transition (EMT) that characterizes the tissue-invasive phenotype. However, the molecular mechanisms by which the β-catenin–TCF complex induces EMT-like programmes remain undefined. Here, we demonstrate that canonical Wnt signalling engages tumour cell dedifferentiation and tissue-invasive activity through an Axin2-dependent pathway that stabilizes the Snail1 zinc-transcription factor, a key regulator of normal and neoplastic EMT programmes. Axin2 regulates EMT by acting as a nucleocytoplasmic chaperone for GSK3β, the dominant kinase responsible for controlling Snail1 protein turnover and activity. As dysregulated Wnt signalling marks a diverse array of cancerous tissue types, the identification of a β-catenin–TCF-regulated Axin2–GSK3β–Snail1 axis provides new mechanistic insights into cancer-associated EMT programmes.
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Cites
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Cited by
Molecular mechanisms of epithelial–mesenchymal transition
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Metadata
- Authors
- Yook, J. I., Li, X.-Y., Ota, I., Hu, C., Kim, H. S., Kim, N. H., Cha, S. Y., Ryu, J. K., Choi, Y. J., Kim, J., Fearon, E. R., & Weiss, S. J.
- Venue
- Nature Cell Biology
- Published
- 2006-10-29
- Volume
- 8
- Issue
- 12
- Pages
- 1398-1406
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2161025693
- Cited by
- 616
- References
- 30
- FWCI
- 8.47
- Type
- journal article
- Language
- en
- Open access
- green
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- Yook, J. I., Li, X.-Y., Ota, I., Hu, C., Kim, H. S., Kim, N. H., Cha, S. Y., Ryu, J. K., Choi, Y. J., Kim, J., Fearon, E. R., & Weiss, S. J. (2006). A Wnt–Axin2–GSK3β cascade regulates Snail1 activity in breast cancer cells. Nature Cell Biology. https://doi.org/10.1038/ncb1508
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