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Cited by 39Psoriasis: Treatment and PathogenesisDermatology and Skin DiseasesSkin Protection and Aging

Spectral effects of UV on psoriasis

Open access
Weatherhead, Sophie C., Farr, Peter M., Reynolds, Nicholas J.·2012·Photochemical & Photobiological Sciences
DOI 10.1039/c2pp25116gPMC PMC4029364
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Abstract

Ultraviolet B (UVB) is a highly effective, relatively safe, affordable and widely used therapeutic option for moderate psoriasis. Several types of UVB lamp are available to treat psoriasis, both broadband and narrowband, allowing a choice of spectral emission. However despite years of clinical use, the mechanism of action of UVB in clearing psoriasis remained incompletely understood. Moreover, there has been little insight into how the relative effectiveness of different UVB wavelengths linked to the mechanism of action, although it is known that the action spectrum for clearance of psoriasis differs from the action spectrum of erythema. This paper examines the existing literature from which our current treatments have evolved, and offers new insight into the use of keratinocyte apoptosis as a biomarker which may help to optimise UV treatment in the future. When combined with a systems biology approach, this potential biomarker may provide insight into which wavelengths of UV are the most effective in clearing psoriasis, allowing a more rational and potentially an individually tailored approach to optimising phototherapy for psoriasis.

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Authors
Weatherhead, S. C., Farr, P. M., & Reynolds, N. J.
Affiliations
Royal Victoria Infirmary (GB)
Corresponding author
Weatherhead, Sophie C.
ORCID
Weatherhead, Sophie C.
Venue
Photochemical & Photobiological Sciences
Publisher
Springer Science and Business Media LLC
Published
2012-01
Volume
12
Issue
1
Pages
47-53
ISSN
  • 1474-905X (ISSN-L)
  • 1474-9092
DOI
10.1039/c2pp25116g
PMC
PMC4029364
OpenAlex
W2016671126
Cited by
39
References
1
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 5 · 2016: 1 · 2015: 3 · 2014: 4 · 2013: 5
FWCI
1.68
Type
journal article
Language
en
Open access
Licence
Locations
  • Photochemical & Photobiological Sciences (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • Newcastle University ePrints (Newcastle Univesity)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Keywords
psoriasis, UVB phototherapy, narrowband UVB, broadband UVB, action spectrum, keratinocyte apoptosis, biomarkers, systems biology
MeSH terms
Humans, Psoriasis, Ultraviolet Rays, Ultraviolet Therapy, Apoptosis

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