The wavelengths in sunlight effective in producing skin cancer: a theoretical analysis
Open accessAbstract
DNA is taken as the target for skin cancer induced by ultraviolet light, and the known data on the sensitivity of DNA as a function of wavelength are summarized. The sun's spectrum at the surface of the earth and the DNA action spectrum are used to calculate the carcinogenic effectiveness as a function of wavelength. The most effective wavelengths at 30°N latitude are <305 nm, and a 1% change in atmospheric ozone results in a 2% change in the effective dose of ultraviolet light. Since both the basic biological and physical data are reasonably precise, the major requirement for a quantitative evaluation of the dose response relation for ultraviolet-induced skin cancer in man is better epidemiological data to compare with data from animal models.
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Relevant UVR-induced DNA damage markers such as cyclobutene pyrimidine dimers cannot be measured in SC tapes.
“In addition, relevant UVRinduced DNA damage markers such as cyclobutene pyrimidine dimers cannot be measured in SC tapes (Kraemer, 1997;Setlow, 1974).”
From Effect of Repeated Low-Dose UVR Exposure on Skin Inflammation Threshold, Skin Biomarkers, and Vitamin D in Healthy Adults (2025) · cites this paper as Setlow, 1974
The paper’s discussion of UV action spectra identifies cyclobutane pyrimidine dimers as DNA products formed by UV exposure. It does not discuss stratum corneum (SC) tapes or say that these markers cannot be measured in them. (LLM, conf=0.84)
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- Authors
- Setlow, R. B.
- Affiliations
- Oak Ridge National Laboratory (US)
- Corresponding author
- Setlow, R. B.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1974-09
- Volume
- 71
- Issue
- 9
- Pages
- 3363-3366
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC433772
- OpenAlex
- W2092873988
- Cited by
- 1,125
- References
- 20
- Citations by year
- 2026: 12 · 2025: 6 · 2024: 13 · 2023: 14 · 2022: 13 · 2021: 14 · 2020: 23 · 2019: 13 · 2018: 18 · 2017: 17 · 2016: 20 · 2015: 19 · 2014: 21 · 2013: 18 · 2012: 21
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- ultraviolet radiation, skin cancer, solar spectrum, atmospheric ozone, dose-response relationship, UV-induced DNA damage, latitude effects
- MeSH terms
- DNA, Dose-Response Relationship, Radiation, Environmental Exposure, Models, Biological, Ozone, Photochemistry, Radiation Injuries, Skin Neoplasms, Sunlight, Ultraviolet Rays
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