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Temperature-sensitive nanogels: poly(N-vinylcaprolactam) versus poly(N-isopropylacrylamide)
Abstract
Poly(N-isopropylacrylamide) (PNIPAM) and poly(N-vinylcaprolactam) (PVCL) are temperature-responsive polymers which show a lower critical solution temperature (LCST) around 32 °C in aqueous solutions. Nanogels based on these temperature sensitive polymers swell at low temperatures and collapse at high ones, showing a volume phase transition temperature (VPTT) near physiological temperature. This unique behavior makes these nanogels attractive for biotechnological applications. PNIPAM is the building block of a huge amount of nanogels reported in the literature. However, PVCL is especially interesting due to the fact that it is very stable against hydrolysis and biocompatible. In this mini-review, various synthesis procedures together with the functionalization of different PNIPAM- and PVCL-based nanogels are revised and compared.
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Citations
Cited by
Kamaly, N., Yameen, B., Wu, J., & Farokhzad, O. C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00346 · Cited by 3,070
Thermo-responsive polymers and their application as smart biomaterials
Kim, Y.-J., & Matsunaga, Y. T. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00157f · Cited by 568
Poly(N-vinylcaprolactam), a comprehensive review on a thermoresponsive polymer becoming popular
Cortez-Lemus, N. A., & Licea-Claverie, A. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2015.08.001 · Cited by 408
Polymeric nanostructured materials for biomedical applications
Tang, Z., He, C., Tian, H., Ding, J., Hsiao, B. S., Chu, B., & Chen, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.05.005 · Cited by 363
Metadata
- Authors
- Ramos, J., Imaz, A., & Forcada, J.
- Venue
- Polym. Chem.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 3
- Issue
- 4
- Pages
- 852-856
- ISSN
- 1759-9954 (ISSN-L)
- 1759-9962
- OpenAlex
- W2037136982
- Cited by
- 297
- References
- 0
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ramos, J., Imaz, A., & Forcada, J. (2012). Temperature-sensitive nanogels: poly(N-vinylcaprolactam) versus poly(N-isopropylacrylamide). Polym. Chem. https://doi.org/10.1039/c2py00485b
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