Cited by 568Hydrogels: synthesis, properties, applicationsAdvanced Materials and MechanicsAdvanced Polymer Synthesis and Characterization

Thermo-responsive polymers and their application as smart biomaterials

Kim, Young-Jin, Matsunaga, Yukiko T.·2017·Journal of Materials Chemistry B

Abstract

This review summarises smart thermo-responsive polymeric materials with reversible and ‘on–off’ remotely switchable properties for a wide range of biomedical and biomaterials applications.

Integrity signals

Registry

Crossref · 10.1039/c7tb00157f

Cites

137 of 137 references verified0 citation errors · 0 not checkable

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  • Thermo-responsive one-way SMPs can switch their shape or elastic network with interaction of temperature above their melting temperature or glass-transition temperature.

    “Thermo-responsive one-way SMPs,19 which can switch their shape or elastic network with the interaction of temperature above their melting temperature (Tm) or glass-transition temperature (Tg), attracted many material chemists due to their various potential applications in actuators,20 self-healing materials,21 biomedicine,22,23 and aerospace engineering.24”
  • PNIPAM is the most widely used temperature-responsive polymer with the advantage of low LCST (32 °C) in an aqueous solution and becomes hydrophobic above LCST.

    “Poly N-isopropyl acrylamide (PNIPAM) is the most widely used temperature-responsive polymer with the advantage of low LCST (32 °C) in an aqueous solution and becomes hydrophobic above LCST.172”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [172]

  • The lower critical solution temperature (LCST) and the upper critical solution temperature (UCST) are the two primary properties of thermosensitive materials employed in thermally responsive smart nanosystems.

    “The lower CST (critical solution temperature) (LCST) and the upper CST (UCST) are the two primary properties of thermosensitive materials employed in thermally responsive smart nanosystems.170”

    From Smart nanoparticles for cancer therapy (2023) · cites this paper as [170]

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Authors
Kim, Y.-J., & Matsunaga, Y. T.
Affiliations
  • RIKEN (JP)
  • The University of Tokyo (JP)
Corresponding author
Matsunaga, Yukiko T.
Venue
Journal of Materials Chemistry B
Published
2017
Volume
5
Issue
23
Pages
4307-4321
ISSN
  • 2050-750X (ISSN-L)
  • 2050-7518
OpenAlex
W2591444020
Cited by
568
References
137
Citations by year
2026: 38 · 2025: 54 · 2024: 56 · 2023: 68 · 2022: 64 · 2021: 90 · 2020: 97 · 2019: 55 · 2018: 36 · 2017: 10
FWCI
20.78
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Materials Chemistry B (publishedVersion)
  • PubMed (publishedVersion)
Funders
Japan Society for the Promotion of Science (16K16403)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
  • Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
Keywords
thermoresponsive polymers, smart biomaterials, lower critical solution temperature, upper critical solution temperature, stimuli-responsive materials, hydrogels, smart surfaces

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