Thermo-responsive polymers and their application as smart biomaterials
Abstract
This review summarises smart thermo-responsive polymeric materials with reversible and ‘on–off’ remotely switchable properties for a wide range of biomedical and biomaterials applications.
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Thermo-responsive one-way SMPs can switch their shape or elastic network with interaction of temperature above their melting temperature or glass-transition temperature.
“Thermo-responsive one-way SMPs,19 which can switch their shape or elastic network with the interaction of temperature above their melting temperature (Tm) or glass-transition temperature (Tg), attracted many material chemists due to their various potential applications in actuators,20 self-healing materials,21 biomedicine,22,23 and aerospace engineering.24”
PNIPAM is the most widely used temperature-responsive polymer with the advantage of low LCST (32 °C) in an aqueous solution and becomes hydrophobic above LCST.
“Poly N-isopropyl acrylamide (PNIPAM) is the most widely used temperature-responsive polymer with the advantage of low LCST (32 °C) in an aqueous solution and becomes hydrophobic above LCST.172”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [172]
The lower critical solution temperature (LCST) and the upper critical solution temperature (UCST) are the two primary properties of thermosensitive materials employed in thermally responsive smart nanosystems.
“The lower CST (critical solution temperature) (LCST) and the upper CST (UCST) are the two primary properties of thermosensitive materials employed in thermally responsive smart nanosystems.170”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [170]
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Smart nanoparticles for cancer therapy
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- Authors
- Kim, Y.-J., & Matsunaga, Y. T.
- Affiliations
- RIKEN (JP)
- The University of Tokyo (JP)
- Corresponding author
- Matsunaga, Yukiko T.
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 5
- Issue
- 23
- Pages
- 4307-4321
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W2591444020
- Cited by
- 568
- References
- 137
- Citations by year
- 2026: 38 · 2025: 54 · 2024: 56 · 2023: 68 · 2022: 64 · 2021: 90 · 2020: 97 · 2019: 55 · 2018: 36 · 2017: 10
- FWCI
- 20.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (16K16403)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Mechanical Engineering › Advanced Materials and Mechanics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- thermoresponsive polymers, smart biomaterials, lower critical solution temperature, upper critical solution temperature, stimuli-responsive materials, hydrogels, smart surfaces
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