Biocompatible and degradable poly(2-hydroxyethyl methacrylate) based polymers for biomedical applications
Abstract
The present work provides a new, well characterized hydroxyl functionalized biocompatible and degradable polymer that could be suitable for many different biomedical applications. Poly(2-hydroxyethyl methacrylate) (PHEMA) is a widely used and researched biocompatible polymer, but lacks degradability. In this work, degradable and less toxic PHEMA with ester linkages in the backbone could be successfully made by radical copolymerization with cyclic ketene acetal. The protection–deprotection chemistry at the hydroxyl group of HEMA was necessary for the formation of targeted polymers. The structure of the resulting polymers was unambiguously proved by 2D NMR techniques. The polymers were significantly less toxic with cell viabilities of more than 80% even for very high polymer concentrations (100 mg mL−1). The polymers were hydrolytically degradable under basic conditions and also showed surface and bulk degradation using macrophages. We also demonstrated promising positive results for the use of such polymers as sustained drug delivery systems.
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Increasing interest in biodegradable polyesters and the versatility of RROP with respect to structures accessible via different monomers and their copolymerization with conventional vinyl monomers has changed the situation significantly.
“However, with the increasing interest in biodegradable polyesters and the versatility of RROP with respect to the structures accessible via very different monomers [25] and their copolymerization with conventional vinyl monomers [26 -34] has changed the situation significantly.”
From Ring-Opening Polymerization—An Introductory Review (2013) · cites this paper as [30]
Cites
Mosmann, T. (1983) · Journal of Immunological Methods · doi:10.1016/0022-1759(83)90303-4 · Cited by 56,104 · see citing works
Atom Transfer Radical Polymerization of 2-Hydroxyethyl Methacrylate
Beers, K. L., Boo, S., Gaynor, S. G., et al. (1999) · Macromolecules · doi:10.1021/ma990176p · Cited by 288 · see citing works
Controlled Polymerization of 2-Hydroxyethyl Methacrylate by ATRP at Ambient Temperature
Robinson, K. L., Khan, M. A., Báñez, M. V. D. P., Wang, X. S., & Armes, S. P. (2001) · Macromolecules · doi:10.1021/ma0019611 · Cited by 266 · see citing works
Agarwal, S. (2010) · Polymer Chemistry · doi:10.1039/c0py00040j · Cited by 263 · see citing works
Self-citationAtzet, S., Curtin, S., Trinh, P., Bryant, S., & Ratner, B. (2008) · Biomacromolecules · doi:10.1021/bm800686h · Cited by 173 · see citing works
Kelen, T., Tüdöus, F., Turcsanyi, B., et al. (1977) · Journal of Polymer Science Polymer Chemistry Edition · doi:10.1002/pol.1977.170151219 · Cited by 160 · see citing works
Confidence intervals for copolymerization reactivity ratios determined by the Kelen-T�d�s method
Kelen, T., T�d�s, F., & Turcs�nyi, B. (1980) · Polymer Bulletin · doi:10.1007/bf00275556 · Cited by 146 · see citing works
Poly(2-hydroxyethyl methacrylate) film as a drug delivery system for pilocarpine
Hsiue, G., Guu, J.-A., & Cheng, C.-C. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00336-7 · Cited by 114 · see citing works
Agarwal, S., Kumar, R., Kissel, T., & Reul, R. (2009) · Polymer Journal · doi:10.1295/polymj.pj2009091 · Cited by 83 · see citing works
Self-citationDziubla, T. D., Torjman, M. C., Joseph, J. I., et al. (2001) · Biomaterials · doi:10.1016/s0142-9612(01)00035-7 · Cited by 82 · see citing works
Oh, J. K., & Matyjaszewski, K. A. (2006) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.21482 · Cited by 77 · see citing works
Poly(hydroxyethyl methacrylate)‐Based Macroporous Hydrogels with Disulfide Cross‐Linker
Andaç, M., Plieva, F. M., Deni̇zli̇, A., Galaev, I. Y., & Mattìasson, B. (2008) · Macromolecular Chemistry and Physics · doi:10.1002/macp.200700467 · Cited by 75 · see citing works
Beck‐Broichsitter, M., Thieme, M., Nguyen, J., et al. (2010) · Macromolecular Bioscience · doi:10.1002/mabi.201000100 · Cited by 63 · see citing works
Self-citationSeema, A., & Liqun, R. (2009) · Macromolecules · doi:10.1021/ma802615f · Cited by 58 · see citing works
Casadio, Y. S., Brown, D. H., Chirilă, T. V., Kraatz, H., & Baker, M. V. (2010) · Biomacromolecules · doi:10.1021/bm100756c · Cited by 56 · see citing works
Oster, C. G., Wittmar, M., Bakowsky, U., et al. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.12.004 · Cited by 43 · see citing works
Self-citationRen, L., Speyerer, C., & Agarwal, S. (2007) · Macromolecules · doi:10.1021/ma0711588 · Cited by 39 · see citing works
Self-citationSynthesis of a New PHEMA/PEO Enzymatically Biodegradable Hydrogel
Khelfallah, N. S., Decher, G., & Mésini, P. J. (2006) · Macromolecular Rapid Communications · doi:10.1002/marc.200600210 · Cited by 21 · see citing works
Park, E. K., Kim, S. Y., Lee, S. B., et al. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.01.009 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Tardy, A., Nicolas, J., Gigmes, D., Lefay, C., & Guillaneuf, Y. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00319 · Cited by 469 · see citing works
Ring-Opening Polymerization—An Introductory Review
Nuyken, O., & Pask, S. (2013) · Polymers · doi:10.3390/polym5020361 · Cited by 456 · see citing works
“However, with the increasing interest in biodegradable polyesters and the versatility of RROP with respect to the structures accessible via very different monomers [25] and their copolymerization with conventional vinyl monomers [26–34] has changed the situation significantly.”
Pesenti, T., & Nicolas, J. (2020) · ACS Macro Letters · doi:10.1021/acsmacrolett.0c00676 · Cited by 214 · see citing works
Synthetically controlling dendrimer flexibility improves delivery of large plasmid DNA
Kretzmann, J. A., Ho, D., Evans, C. W., Plani-Lam, J. H. C., García‐Bloj, B., Mohamed, A. E., O’Mara, M. L., Ford, E., Tan, D. E. K., Lister, R., et al. (2017) · Chemical Science · doi:10.1039/c7sc00097a · Cited by 127 · see citing works
Delplace, V., Tardy, A., Harrisson, S., Mura, S., Gigmès, D., Guillaneuf, Y., & Nicolas, J. (2013) · Biomacromolecules · doi:10.1021/bm401157g · Cited by 109 · see citing works
Lefay, C., & Guillaneuf, Y. (2023) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2023.101764 · Cited by 101 · see citing works
Reversible-deactivation radical polymerization of cyclic ketene acetals
Jackson, A. W. (2020) · Polymer Chemistry · doi:10.1039/d0py00446d · Cited by 89 · see citing works
Polymeric biomaterials with engineered degradation
Deshayes, S., & Kasko, A. M. (2013) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.26765 · Cited by 90 · see citing works
Radical Ring-Opening Copolymerization-Induced Self-Assembly (rROPISA)
Guégain, E., Zhu, C., Giovanardi, E., & Nicolas, J. (2019) · Macromolecules · doi:10.1021/acs.macromol.9b00161 · Cited by 84 · see citing works
New unsaturated copolyesters based on 2,5-furandicarboxylic acid and their crosslinked derivatives
Sousa, A. F., Fonseca, A. C., Serra, A. C., Freire, C. S. R., Silvestre, A. J. D., & Coelho, J. F. J. (2015) · Polymer Chemistry · doi:10.1039/c5py01702e · Cited by 76 · see citing works
Biomaterials for revascularization and immunomodulation after spinal cord injury
Haggerty, A. E., Maldonado, I. C., & Oudega, M. (2018) · Biomedical Materials · doi:10.1088/1748-605x/aaa9d8 · Cited by 74 · see citing works
Tran, J., Guégain, E., Ibrahim, N., Harrisson, S., & Nicolas, J. (2016) · Polymer Chemistry · doi:10.1039/c6py00778c · Cited by 69 · see citing works
Gigmès, D., Steenberge, P. H. M. V., Siri, D., D’hooge, D., Guillaneuf, Y., & Lefay, C. (2018) · Macromolecular Rapid Communications · doi:10.1002/marc.201800193 · Cited by 66 · see citing works
Wang, C., Rubakhin, S. S., Enright, M. J., Sweedler, J. V., & Nuzzo, R. G. (2021) · Advanced Functional Materials · doi:10.1002/adfm.202010246 · Cited by 63 · see citing works
Delplace, V., Guégain, E., Harrisson, S., Gigmès, D., Guillaneuf, Y., & Nicolas, J. (2015) · Chemical Communications · doi:10.1039/c5cc04610f · Cited by 64 · see citing works
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Maturi, M., Pulignani, C., Locatelli, E., Buratti, V. V., Tortorella, S., Sambri, L., & Franchini, M. C. (2020) · Green Chemistry · doi:10.1039/d0gc01983f · Cited by 62 · see citing works
Micropatterned Hydrogel Surface with High-Aspect-Ratio Features for Cell Guidance and Tissue Growth
Hu, Y., You, J., & Aizenberg, J. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b12268 · Cited by 61 · see citing works
Synthesis and High-Throughput Processing of Polymeric Hydrogels for 3D Cell Culture
Lowe, S. B., Tan, V. T. G., Soeriyadi, A. H., Davis, T. P., & Gooding, J. J. (2014) · Bioconjugate Chemistry · doi:10.1021/bc500310v · Cited by 59 · see citing works
Delplace, V., Harrisson, S., Tardy, A., Gigmès, D., Guillaneuf, Y., & Nicolas, J. (2013) · Macromolecular Rapid Communications · doi:10.1002/marc.201300809 · Cited by 57 · see citing works
Lu, Z., Gao, W., Liu, F., Cui, J., Feng, S., Chen, L., Guo, Y., Wang, Z., Mao, Z., & Zhang, B. (2024) · Additive manufacturing · doi:10.1016/j.addma.2024.104443 · Cited by 62 · see citing works
All-Optical Thermometry with Nitrogen-Vacancy Centers in Nanodiamond-Embedded Polymer Films
Hui, Y. Y., Chen, O. Y., Azuma, T., Chang, B., Hsieh, F., & Chang, H. (2019) · The Journal of Physical Chemistry C · doi:10.1021/acs.jpcc.9b04496 · Cited by 57 · see citing works
Lena, J.-B., & van Herk, A. M. (2019) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.9b02375 · Cited by 56 · see citing works
The usage of composite nanomaterials in biomedical engineering applications
Akgöl, S., Ulucan‐Karnak, F., Kuru, C. İ., et al. (2021) · Biotechnology and Bioengineering · doi:10.1002/bit.27843 · Cited by 55 · see citing works
A Review on Styrene Substitutes in Thermosets and Their Composites
Wu, Y., Fei, M., Qiu, R., et al. (2019) · Polymers · doi:10.3390/polym11111815 · Cited by 52 · see citing works
Controlling fungal biofilms with functional drug delivery denture biomaterials
Wen, J., Jiang, F., Yeh, C., et al. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.12.028 · Cited by 47 · see citing works
Ding, D., Pan, X., Zhang, Z., Li, N., Zhu, J., & Zhu, X. (2016) · Polymer Chemistry · doi:10.1039/c6py01061j · Cited by 47 · see citing works
Rough Adhesive Hydrogels (RAd gels) for Underwater Adhesion
Bradley, L. C., Bade, N. D., Mariani, L. M., Turner, K. T., Lee, D., & Stebe, K. J. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b08916 · Cited by 47 · see citing works
Doxorubicin Imprinted Photoluminescent Polymer as a pH-Responsive Nanocarrier
Javanbakht, S., Saboury, A., Shaabani, A., et al. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00254 · Cited by 46 · see citing works
Ko, K., Lundberg, D. J., Johnson, A. M., & Johnson, J. A. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c14554 · Cited by 45 · see citing works
Ghitescu, R.-E., Popa, A., Popa, V., et al. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.08.020 · Cited by 43 · see citing works
Rabeh, M. I., Vora, L. K., Moore, J. V., Bayan, M. F., McCoy, C. P., & Wylie, M. P. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213735 · Cited by 42 · see citing works
Jackson, A. W., Mothe, S. R., Ang, P., Chennamaneni, L. R., van Herk, A. M., & Thoniyot, P. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2021.133487 · Cited by 42 · see citing works
3D printed polymer composite optical fiber for sensing applications
Alam, F., Elsherif, M., Salih, A. E., et al. (2022) · Additive manufacturing · doi:10.1016/j.addma.2022.102996 · Cited by 39 · see citing works
Zhou, Y., Luo, Z., & Chen, J. (2013) · AIChE Journal · doi:10.1002/aic.14057 · Cited by 32 · see citing works
Pesenti, T., Zhu, C., Gonzalez-Martinez, N., Tomás, R. M. F., Gibson, M. I., & Nicolas, J. (2022) · ACS Macro Letters · doi:10.1021/acsmacrolett.2c00298 · Cited by 25 · see citing works
Ruiz‐Cantu, L., Pearce, A. K., Burroughs, L., Bennett, T. M., Vasey, C. E., Wildman, R. D., Irvine, D. J., Alexander, C., & Taresco, V. (2018) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201800459 · Cited by 22 · see citing works
Kim, H., Yeow, J., Najer, A., Kit‐Anan, W., Wang, R., Rifaie‐Graham, O., Thanapongpibul, C., & Stevens, M. M. (2022) · Advanced Science · doi:10.1002/advs.202200239 · Cited by 20 · see citing works
Biomimetic Mineralization of Tannic Acid-Supplemented HEMA/SBMA Nanocomposite Hydrogels
Chen, T., Ou, S., & Chien, H. (2021) · Polymers · doi:10.3390/polym13111697 · Cited by 19 · see citing works
Drozdov, A. D., Sanporean, C., & Christiansen, J. D. C. (2014) · International Journal of Solids and Structures · doi:10.1016/j.ijsolstr.2014.10.009 · Cited by 19 · see citing works
Functionalized Denture Resins as Drug Delivery Biomaterials to Control Fungal Biofilms
Wen, J., Yeh, C., & Sun, Y. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00416 · Cited by 19 · see citing works
Xiao, M., González, E., Monterroza, A. M., et al. (2017) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2017.06.092 · Cited by 19 · see citing works
Shahbazi, S., Zamanian, A., Pazouki, M., et al. (2018) · Materials Science and Engineering C · doi:10.1016/j.msec.2017.12.033 · Cited by 18 · see citing works
Coulomb interaction-driven UCST in poly(ionic liquid) random copolymers
Banerjee, P., Jana, S., & Mandal, T. K. (2020) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.109747 · Cited by 17 · see citing works
Lehman, S. E., McCracken, J. M., Miller, L. A., Jayalath, S., & Nuzzo, R. G. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202001040 · Cited by 17 · see citing works
Polymer Brush Functionalization of Polyurethane Tunable Nanopores for Resistive Pulse Sensing
Srinivas, A. R. G., Hilali, R., Damavandi, M., et al. (2020) · ACS Applied Polymer Materials · doi:10.1021/acsapm.0c01087 · Cited by 17 · see citing works
Hazra, R., Alam, M. S. S., Malakar, A., et al. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143467 · Cited by 16 · see citing works
UV polymerization fabrication method for polymer composite based optical fiber sensors
Ahmed, I., Ali, M., Elsherif, M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-33991-6 · Cited by 16 · see citing works
Poveda‐Reyes, S., Rodrigo‐Navarro, A., Gamboa‐Martínez, T. C., Rodríguez‐Cabello, J. C., Quintanilla‐Sierra, L., Edlund, U., & Ferrer, G. G. (2015) · Polymer · doi:10.1016/j.polymer.2015.08.018 · Cited by 13 · see citing works
Borzenkov, M., Mitina, N., Lobaz, V., & Hevus, O. (2014) · Journal of Surfactants and Detergents · doi:10.1007/s11743-014-1640-z · Cited by 13 · see citing works
Degradable Vinyl-Based Polymers by Radical Ring-Opening Polymerization: A User Guide
Luzel, B., Kouider, S., D’Agosto, F., Gigmès, D., Lansalot, M., Bates, C. M., Ackerman, E., Labalme, S., Johnson, J. A., Niu, J., et al. (2026) · ACS Polymers Au · doi:10.1021/acspolymersau.5c00191 · Cited by 11 · see citing works
Insertion of ester bonds in three terpolymerization systems
Lena, J.-B., Ramalingam, B., Rusli, W., Chennamaneni, L. R., Thoniyot, P., & van Herk, A. M. (2022) · European Polymer Journal · doi:10.1016/j.eurpolymj.2022.111627 · Cited by 12 · see citing works
Mothe, S. R., Chennamaneni, L. R., Tan, J. S. J., Lim, F. C. H., Zhao, W., & Thoniyot, P. (2023) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202300221 · Cited by 11 · see citing works
Er, T. K. G., Lim, X. Y. H., Oh, X. Y., & Goto, A. (2024) · Macromolecules · doi:10.1021/acs.macromol.4c01638 · Cited by 9 · see citing works
Amara, H., Alam, F., Turk, S. E., et al. (2025) · Heliyon · doi:10.1016/j.heliyon.2025.e42186 · Cited by 9 · see citing works
Costa, R. O. R., Lameiras, F. S., Nunes, E. H. M., et al. (2015) · Ceramics International · doi:10.1016/j.ceramint.2015.10.145 · Cited by 9 · see citing works
Pearce, A. K., Vasey, C. E., Anane‐Adjei, A. B., Sodano, F., Crucitti, V. C., Irvine, D. J., Howdle, S. M., Alexander, C., & Taresco, V. (2019) · Macromolecular Chemistry and Physics · doi:10.1002/macp.201900270 · Cited by 9 · see citing works
Amado, E., & Kreßler, J. (2016) · Macromolecules · doi:10.1021/acs.macromol.5b02771 · Cited by 9 · see citing works
Wenzel, F., Aguirre, M., & Leiza, J. R. (2024) · Polymer · doi:10.1016/j.polymer.2024.127285 · Cited by 8 · see citing works
Zheng, S., Dai, G., Xue, Q., Liang, R., Zhu, W., Wang, C., & Chen, Y. (2024) · Surface and Coatings Technology · doi:10.1016/j.surfcoat.2024.130528 · Cited by 8 · see citing works
Kumar, S., Lee, S., Thomas, R. G., et al. (2019) · Journal of Polymer Science Part A Polymer Chemistry · doi:10.1002/pola.29370 · Cited by 8 · see citing works
Phenylalanine‐Tethered pH‐Responsive Poly(2‐Hydroxyethyl Methacrylate)
Choudhury, N., Das, S., Samadder, S., et al. (2021) · Chemistry - An Asian Journal · doi:10.1002/asia.202100136 · Cited by 8 · see citing works
Özay, Ö., & Yilmaz, B. (2021) · Biointerface Research in Applied Chemistry · doi:10.33263/briac123.36643680 · Cited by 7 · see citing works
Developing Transparent and Conductive PolyHEMA Gels Using Deep Eutectic Solvents
Chen, T., Jiang, Y., & Chien, H. (2023) · Polymers · doi:10.3390/polym15122605 · Cited by 7 · see citing works
Kulabas, S. S., Atli, İ., Atalay, H. N., et al. (2025) · Emergent Materials · doi:10.1007/s42247-025-01225-2 · Cited by 5 · see citing works
In Search of a Weak Link: Toward Biodegradability and Circular Economies Using Cyclic Ketene Acetals
Jackson, A. W., van Herk, A. M., & Thoniyot, P. (2025) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.5c03872 · Cited by 5 · see citing works
Chen, J., & Jackson, N. E. (2025) · Chemistry of Materials · doi:10.1021/acs.chemmater.5c01608 · Cited by 4 · see citing works
González‐Ayón, M. A., Hoppenstedt, A. M., Zizumbo‐López, A., et al. (2024) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202400018 · Cited by 4 · see citing works
Güler, C., Gülcemal, S., Güner, A., et al. (2022) · Polymer Bulletin · doi:10.1007/s00289-022-04607-2 · Cited by 4 · see citing works
Cryogels: Applications in Extracorporeal Affinity Therapy
Yavuz, H., Bereli, N., Baydemir, G., et al. (2016) · CRC Press eBooks · doi:10.1201/b19676-18 · Cited by 4 · see citing works
Sharma, D., & Singh, B. (2025) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2025.100474 · Cited by 3 · see citing works
Däbritz, S. B., Neubauer, K., Kropf, C., & Agarwal, S. (2025) · Macromolecular Chemistry and Physics · doi:10.1002/macp.202500080 · Cited by 3 · see citing works
Self-citationDu, Y., Yang, Y., Deglmann, P., Holcombe, T. W., Du, Y., & Coughlin, E. B. (2023) · Journal of Polymer Science · doi:10.1002/pol.20230480 · Cited by 3 · see citing works
Synthetic Organic Materials for Targeting Immunotherapies to Lymph Nodes
Bridgeman, C. J., Shen, R., McIlvaine, R. A., Edwards, C., Ackun‐Farmmer, M. A., & Jewell, C. M. (2024) · Chemistry of Materials · doi:10.1021/acs.chemmater.4c00947 · Cited by 3 · see citing works
Kinetic Features of Radical Ring-Opening Polymerization of Ketene Acetals
Zaremski, M. Y., & Aliev, E. E. (2024) · Polymer Science Series B · doi:10.1134/s156009042460147x · Cited by 3 · see citing works
Poly(hydroxyethyl methacrylate) Saliva-Gel: A Polymer-Based Solution for Xerostomia Treatment
Debnath, S., Paz, C., Scofield, D., et al. (2025) · ACS Applied Polymer Materials · doi:10.1021/acsapm.5c00881 · Cited by 2 · see citing works
Macromolecular approach for targeted radioimmunotherapy in non-Hodgkin's lymphoma
Hee, C., Ho, D., Karton, A., et al. (2019) · Chemical Communications · doi:10.1039/c9cc06603a · Cited by 2 · see citing works
Functional (Bio)degradable Polyesters by Radical Ring‐Opening Polymerization
Agarwal, S. (2015) · Wiley eBooks · doi:10.1002/9783527656950.ch2 · Cited by 2 · see citing works
Self-citationProtein-based injectable hydrogels towards the regeneration of articular cartilage
Poveda‐Reyes, S. (2016) · doi:10.4995/thesis/10251/61392 · Cited by 2 · see citing works
Das, R., & Mondal, S. (2024) · Journal of Environmental Informatics Letters · doi:10.3808/jeil.202400122
Кинетические особенности радикальной полимеризации кетенацеталей с раскрытием цикла
Заремский, М. Ю., & Aliev, E. E. (2024) · Высокомолекулярные соединения С · doi:10.31857/s2308114724020019
Chen, Y., Shan, F., Yuan, J., Pan, Y., Duan, Y., & Chen, G. (2026) · Biomacromolecules · doi:10.1021/acs.biomac.6c00409
- Authors
- Zhang, Y., Chu, D., Zheng, M., Kissel, T., & Agarwal, S.
- Affiliations
- Philipps University of Marburg (DE)
- Corresponding author
- Agarwal, Seema
- ORCID
- Agarwal, Seema
- Venue
- Polymer Chemistry
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 3
- Issue
- 10
- Pages
- 2752
- ISSN
- 1759-9954 (ISSN-L)
- 1759-9962
- OpenAlex
- W2152653111
- Cited by
- 86
- References
- 19
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 10 · 2023: 6 · 2022: 7 · 2021: 6 · 2020: 7 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 6 · 2015: 8 · 2014: 4 · 2013: 5
- FWCI
- 2.21
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Polymer Chemistry (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Keywords
- poly(2-hydroxyethyl methacrylate), cyclic ketene acetals, hydroxyl group protection, radical copolymerization, biodegradable polymers, biocompatibility, cytotoxicity, cell viability, hydrolytic degradation, sustained drug release
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