The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Iridium(iii) complexes as therapeutic and bioimaging reagents for cellular applications
Abstract
There is an emerging interest in applying inorganic and organometallic transition metal complexes to biomolecular and cellular studies. The cytotoxic effects of these complexes on various cancer and normal cells have been examined. Many of these complexes display intense, long-lived, and environment-sensitive emission, rendering them useful live-cell imaging reagents. Of particular interest are iridium(III) complexes, which possess a diversity of molecular structures with intriguing biological activity and photophysical properties. In this review article, we summarize recent work using iridium(III) complexes as anticancer drugs and cellular imaging reagents. We focus on the cytotoxic activity, cellular uptake efficiency and mechanisms, and intracellular distribution properties of these complexes. Additionally, we describe the applications of luminescent iridium(III) complexes in intracellular sensing for ions and small molecules, gene-delivery, and cancer cell detection.
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Cites
Signalling pathways of the TNF superfamily: a double-edged sword
Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793
Cited by
Organoiridium Complexes: Anticancer Agents and Catalysts
Liu, Z., & Sadler, P. J. (2014) · Accounts of Chemical Research · doi:10.1021/ar400266c · Cited by 573
Metadata
- Authors
- Lo, K. K.-W., & Zhang, K. Y.
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 2
- Issue
- 32
- Pages
- 12069
- ISSN
- 2046-2069 (ISSN-L)
- OpenAlex
- W2027389851
- Cited by
- 227
- References
- 1
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- closed
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