Signalling pathways of the TNF superfamily: a double-edged sword
Abstract
Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past two decades has shown the existence of a superfamily of TNF proteins consisting of 19 members that signal through 29 receptors. These ligands, while regulating normal functions such as immune responses, haematopoiesis and morphogenesis, have also been implicated in tumorigenesis, transplant rejection, septic shock, viral replication, bone resorption, rheumatoid arthritis and diabetes; so indicating their role as 'double-edged swords'. These cytokines either induce cellular proliferation, survival, differentiation or apoptosis. Blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases in the United States and other countries.
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TNF-α is a pro-inflammatory cytokine and a potent activator of NF-κB, which induces many pro-mitogenic, pro-inflammatory, and anti-apoptotic proteins, promoting cell proliferation and survival.
“TNF-α is a pro-inflammatory cytokine and a potent activator of the transcription factor NF-κB, which induces the expression of a multitude of pro-mitogenic, pro-inflammatory, and anti-apoptotic proteins, thus promoting cell proliferation and survival [102].”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [102]
TNF-α is also a powerful apoptotic inducer in vitro when NF-κB signaling is blocked, typically by cycloheximide.
“However, TNF-α is also a powerful apoptotic inducer in vitro when NF-κB signaling is blocked, typically by the addition of cycloheximide.”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [102]
TNFα acts on its receptors to promote either cell survival or cell death.
“Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine that acts on its receptors (TNFRs) to promote either cell survival or cell death 54.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [54]
Cites
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439 · see citing works
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130 · see citing works
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532 · see citing works
Nagata, S., & Golstein, P. (1995) · Science · doi:10.1126/science.7533326 · Cited by 3,979 · see citing works
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650 · see citing works
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351 · see citing works
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149 · see citing works
Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900 · see citing works
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., & Nagata, S. (1991) · Cell · doi:10.1016/0092-8674(91)90614-5 · Cited by 2,736 · see citing works
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709 · see citing works
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., et al. (1998) · Genes & Development · doi:10.1101/gad.12.9.1260 · Cited by 2,483 · see citing works
Tumor necrosis factor signaling
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,353 · see citing works
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290 · see citing works
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234 · see citing works
Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege
Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995) · Science · doi:10.1126/science.270.5239.1189 · Cited by 1,990 · see citing works
TNF-R1 Signaling: A Beautiful Pathway
Chen, G., & Goeddel, D. V. (2002) · Science · doi:10.1126/science.1071924 · Cited by 1,930 · see citing works
The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
Smith, C. A., Farrah, T., & Goodwin, R. G. (1994) · Cell · doi:10.1016/0092-8674(94)90372-7 · Cited by 1,909 · see citing works
Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family
Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., & Ashkenazi, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.12687 · Cited by 1,777 · see citing works
The Receptor for the Cytotoxic Ligand TRAIL
Pan, G., O’Rourke, K. M., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., & Dixit, V. M. (1997) · Science · doi:10.1126/science.276.5309.111 · Cited by 1,755 · see citing works
Signal transduction by tumor necrosis factor and its relatives.
Baud, V., & Karin, M. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02064-5 · Cited by 1,741 · see citing works
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B., & Goeddel, D. V. (1984) · Nature · doi:10.1038/312724a0 · Cited by 1,732 · see citing works
Self-citationSugarman, B. J., Aggarwal, B. B., Hass, P. E., Figari, I. S., Palladino, M. A., & Shepard, H. M. (1985) · Science · doi:10.1126/science.3933111 · Cited by 1,572 · see citing works
Self-citationMcDermott, M., Aksentijevich, I. A., Galon, J., McDermott, E. M., Ogunkolade, B.-W., Centola, M. B., Mansfield, E. A., Gadina, M., Karenko, L., Pettersson, T., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80721-7 · Cited by 1,404 · see citing works
Yonehara, S., Ishii, A., & Yonehara, M. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1747 · Cited by 1,398 · see citing works
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
Ashkenazi, A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc821 · Cited by 1,351 · see citing works
BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth
Schneider, P., Mackay, F., Steiner, V., Hofmann, K., Bodmer, J.-L., Holler, N., Ambrose, C. M., Lawton, P., Bixler, S. A., Acha‐Orbea, H., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.11.1747 · Cited by 1,334 · see citing works
Grell, M., Douni, E. K., Wajant, H., Löhden, M., Clauss, M. A., Maxeiner, B., Georgopoulos, S., Lesslauer, W., Kollias, G. A., Pfizenmaier, K., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90192-2 · Cited by 1,328 · see citing works
A novel domain within the 55 kd TNF receptor signals cell death
Tartaglia, L. A., Ayres, T. M., Wong, G. H., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90464-2 · Cited by 1,290 · see citing works
MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1
Malinin, N. L., Boldin, M., Kovalenko, A. V., & Wallach, D. (1997) · Nature · doi:10.1038/385540a0 · Cited by 1,279 · see citing works
Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?
Feldmann, M., & Maini, R. N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.163 · Cited by 1,252 · see citing works
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,206 · see citing works
Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease
Cohen, P. L., & Eisenberg, R. A. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.001331 · Cited by 1,169 · see citing works
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
Beutler, B., Greenwald, D., Hulmes, J. D., Chang, M., Pan, Y.-C. E., Mathison, J. C., Ulevitch, R. J., & Cerami, A. (1985) · Nature · doi:10.1038/316552a0 · Cited by 1,132 · see citing works
The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal
Kelliher, M. A., Grimm, S., Ishida, Y., Kuo, F., Stanger, B. Z., & Leder, P. (1998) · Immunity · doi:10.1016/s1074-7613(00)80535-x · Cited by 1,102 · see citing works
BAFF and APRIL: A Tutorial on B Cell Survival
Mackay, F., Schneider, P., Rennert, P. D., & Browning, J. L. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141152 · Cited by 1,004 · see citing works
Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5
Kischkel, F. C., Lawrence, D. A., Chuntharapai, A., Schow, P., Kim, K. J., & Ashkenazi, A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80212-5 · Cited by 975 · see citing works
The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways
Dejardin, E., Droin, N. M., Delhase, M., Haas, E., Cao, Y., Makris, C., Li, Z., Karin, M., Ware, C. F., & Green, D. R. (2002) · Immunity · doi:10.1016/s1074-7613(02)00423-5 · Cited by 923 · see citing works
Human tumor necrosis factor. Production, purification, and characterization.
Aggarwal, B. B., Kohr, W. J., Hass, P. E., Moffat, B., Spencer, S. A., Henzel, W. J., Bringman, T. S., Nedwin, G. E., Goeddel, D. V., & Harkins, R. N. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89560-6 · Cited by 917 · see citing works
Self-citationCharacterization of receptors for human tumour necrosis factor and their regulation by γ-interferon
Aggarwal, B. B., Eessalu, T. E., & Hass, P. E. (1985) · Nature · doi:10.1038/318665a0 · Cited by 876 · see citing works
Self-citationA Domain in TNF Receptors That Mediates Ligand-Independent Receptor Assembly and Signaling
Chan, F. K.-M., Chun, H. J., Zheng, L., Siegel, R. M., Bui, K. L., & Lenardo, M. J. (2000) · Science · doi:10.1126/science.288.5475.2351 · Cited by 856 · see citing works
Wong, B. R., Josien, R., Lee, S. Y., Sauter, B., Li, H.-L., Steinman, R. M., & Choi, Y. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.12.2075 · Cited by 853 · see citing works
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
Itoh, N., & Nagata, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82075-0 · Cited by 845 · see citing works
Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis
Moore, R. J., Owens, D. M., Stamp, G., Arnott, C., Burke, F., East, N., Holdsworth, H., Turner, L., Rollins, B., Pasparakis, M., et al. (1999) · Nature Medicine · doi:10.1038/10552 · Cited by 839 · see citing works
Yeh, W., Shahinian, A., Speiser, D. E., Kraunus, J., Billia, F., Wakeham, A. C., de la Pompa, J. L., Ferrick, D. A., Hum, B., Iscove, N. N., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80391-x · Cited by 798 · see citing works
Nagata, S. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.29 · Cited by 772 · see citing works
Fata, J. E., Kong, Y.-Y., Li, J., Sasaki, T., Irie-Sasaki, J., Moorehead, R. A., Elliott, R., Scully, S., Voura, E. B., Lacey, D. L., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00103-3 · Cited by 756 · see citing works
Gardam, M. A., Keystone, E. C., Menzies, R., Manners, S., Skamene, E., Long, R., & Vinh, D. C. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00545-0 · Cited by 750 · see citing works
CONTRIBUTION TO THE KNOWLEDGE OF SARCOMA
COLEY, W. B. (1891) · Annals of Surgery · doi:10.1097/00000658-189112000-00015 · Cited by 717 · see citing works
Chun, H. J., Zheng, L., Ahmad, M., Wang, J., Speirs, C. K., Siegel, R. M., Dale, J. K., Puck, J. M., Davis, J., Hall, C. G., et al. (2002) · Nature · doi:10.1038/nature01063 · Cited by 706 · see citing works
TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB
Schneider, P., Thome, M., Burns, K., Bodmer, J.-L., Hofmann, K., Kataoka, T., Holler, N., & Tschopp, J. (1997) · Immunity · doi:10.1016/s1074-7613(00)80401-x · Cited by 697 · see citing works
BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells
Claudio, E., Brown, K., Park, S., Wang, H., & Siebenlist, U. K. (2002) · Nature Immunology · doi:10.1038/ni842 · Cited by 694 · see citing works
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity
Gray, P. W., Aggarwal, B. B., Benton, C. V., Bringman, T. S., Henzel, W. J., Jarrett, J. A., Leung, D. W., Moffat, B., Ng, P., Svedersky, L. P., et al. (1984) · Nature · doi:10.1038/312721a0 · Cited by 641 · see citing works
Self-citationTL1A Is a TNF-like Ligand for DR3 and TR6/DcR3 and Functions as a T Cell Costimulator
Migone, T., Zhang, J., Luo, X., Zhuang, L., Chen, C., Hu, B., Hong, J. S., Perry, J. W., Chen, S.-F., Zhou, J. X. H., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00283-2 · Cited by 637 · see citing works
Cretney, E., Takeda, K., Yagita∥, H., Glaccum, M. B., Peschon, J. J., & Smyth, M. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1356 · Cited by 615 · see citing works
Arch, R. H., Gedrich, R. W., & Thompson, C. B. (1998) · Genes & Development · doi:10.1101/gad.12.18.2821 · Cited by 611 · see citing works
Suda, T., Hashimoto, H., Tanaka, M., Ochi, T., & Nagata, S. (1997) · Journal of Experimental Medicine · doi:10.1084/jem.186.12.2045 · Cited by 558 · see citing works
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity
Ichikawa, K., Liu, W., Zhao, L., Wang, Z., Liu, D., Ohtsuka, T., Zhang, H., Mountz, J. D., Koopman, W. J., Kimberly, R. P., et al. (2001) · Nature Medicine · doi:10.1038/91000 · Cited by 544 · see citing works
NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
Dajee, M., Lazarov, M., Zhang, J. Y., Cai, T., Green, C. L., Russell, A. J., Marinkovich, M. P., Tao, S., Lin, Q., Kubo, Y., et al. (2003) · Nature · doi:10.1038/nature01283 · Cited by 535 · see citing works
Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis
Hughes, A. E., Ralston, S. H., Marken, J., Bell, C., Macpherson, H. K., Wallace, R. G. H., Hul, W. V., Whyte, M. P., Nakatsuka, K., Hovy, L., et al. (2000) · Nature Genetics · doi:10.1038/71667 · Cited by 481 · see citing works
Cao, Y., Bonizzi, G., Seagroves, T. N., Greten, F. R., Johnson, R. S., Schmidt, E. V., & Karin, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00599-2 · Cited by 479 · see citing works
Kayagaki, N., Yan, M., Seshasayee, D., Wang, H., Lee, W. P., French, D. M., Grewal, I. S., Cochran, A. G., Gordon, N. C., Yin, J., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00425-9 · Cited by 477 · see citing works
Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation
Legler, D. F., Micheau, O., Doucey, M., Tschopp, J., & Bron, C. (2003) · Immunity · doi:10.1016/s1074-7613(03)00092-x · Cited by 464 · see citing works
Straus, S. E. (2001) · Blood · doi:10.1182/blood.v98.1.194 · Cited by 464 · see citing works
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
Li, X., Yang, Y., & Ashwell, J. D. (2002) · Nature · doi:10.1038/416345a · Cited by 452 · see citing works
Williamson, B., Carswell, E. A., Rubin, B. Y., Prendergast, J., & Old, L. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.17.5397 · Cited by 451 · see citing works
Emanuelli, B., Peraldi, P., Filloux, C., Carine Chavey, A., Freidinger, K., Hilton, D. J., Hotamışlıgil, G. S., & OBBERGHEN, E. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104602200 · Cited by 449 · see citing works
Kelley, S. K., Harris, L. A., Xie, D., DeForge, L. E., Tótpál, K., Bussiere, J., & Fox, J. A. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29298-3 · Cited by 439 · see citing works
Powell, W. C., Fingleton, B., Wilson, C. L., Boothby, M. R., & Matrisian, L. M. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80113-x · Cited by 424 · see citing works
Nocentini, G., Giunchi, L., Ronchetti, S., Krausz, L. T., Bartoli, A., Moraca, R., Migliorati, G., & Riccardi, C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6216 · Cited by 412 · see citing works
Lum, L., Wong, B. R., Josien, R., Becherer, J. D., Erdjument‐Bromage, H., Schlöndorff, J. S., Tempst, P., Choi, Y., & Blobel, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13613 · Cited by 412 · see citing works
Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice
Li, Y., Wu, L., Wesche, H., Arthur, C. D., White, J. M., Goeddel, D. V., & Schreiber, R. D. (2001) · Science · doi:10.1126/science.1058453 · Cited by 408 · see citing works
Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease
Suenaert, P., Bulteel, V., Lemmens, L., Noman, M., Geypens, B. J., Assche, G. V., Geboes, K. J., Ceuppens, J. L., & Rutgeerts, P. J. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05914.x · Cited by 402 · see citing works
Darnay, B. G., Ni, J., Moore, P. A., & Aggarwal, B. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7724 · Cited by 399 · see citing works
Self-citationRomas, E., Gillespie, M., & Martin, T. (2002) · Bone · doi:10.1016/s8756-3282(01)00682-2 · Cited by 390 · see citing works
CRINKLY4: A TNFR-Like Receptor Kinase Involved in Maize Epidermal Differentiation
Becraft, P. W., Stinard, P. S., & McCarty, D. R. (1996) · Science · doi:10.1126/science.273.5280.1406 · Cited by 386 · see citing works
Song, K., Chen, Y., Göke, R., Wilmen, A., Seidel, C., Göke, A., Hilliard, B. A., & Chen, Y. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.7.1095 · Cited by 361 · see citing works
Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL−/− mice
Lamhamedi-Cherradi, S.-E., Zheng, S. J., Maguschak, K. A., Peschon, J. J., & Chen, Y. H. (2003) · Nature Immunology · doi:10.1038/ni894 · Cited by 347 · see citing works
Mukhopadhyay, A., Ni, J., Zhai, Y., Yu, G.-L., & Aggarwal, B. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.15978 · Cited by 319 · see citing works
Self-citationRegulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB
Ravi, R. K., Bedi, G. C., Engstrom, L., Zeng, Q., Mookerjee, B., Gélinas, C., Fuchs, E. J., & Bedi, A. (2001) · Nature Cell Biology · doi:10.1038/35070096 · Cited by 313 · see citing works
Tada, K., Okazaki, T., Sakon, S., Kobarai, T., Kurosawa, K., Yamaoka, S., Hashimoto, H., Mak, T. W., Yagita, H., Okumura, K., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104837200 · Cited by 306 · see citing works
Identification and functional characterization of DR6, a novel death domain‐containing TNF receptor
Pan, G., Bauer, J. H., Haridas, V., Wang, S., Ding, L., Yu, G., Vincenz, C., Aggarwal, B. B., Ni, J., & Dixit, V. M. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00791-1 · Cited by 292 · see citing works
Self-citationAggarwal, B. B., Moffat, B., & Harkins, R. N. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43716-1 · Cited by 290 · see citing works
Self-citationGrell, M., Zimmermann, G., Gottfried, E., Chen, C., Grünwald, U., Huang, D. C. S., Lee, Y. W., Dürkop, H., Engelmann, H., Scheurich, P., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.3034 · Cited by 284 · see citing works
Mekk3 is essential for early embryonic cardiovascular development
Yang, J., Boerm, M., McCarty, M. F., BUCANA, C. D., Fidler, I. J., Yang, Y. Z. J., & Su, B. (2000) · Nature Genetics · doi:10.1038/73550 · Cited by 244 · see citing works
Current uses of isolated limb perfusion in the clinic and a model system for new strategies
Eggermont, A. M. M., de Wilt, J. H., & ten Hagen, T. L. M. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)01141-0 · Cited by 236 · see citing works
Feinberg, B. A., Kurzrock, R., Talpaz, M., Blick, M. B., Saks, S. R., & Gutterman, J. U. (1988) · Journal of Clinical Oncology · doi:10.1200/jco.1988.6.8.1328 · Cited by 221 · see citing works
Harper, N. W., Hughes, M. A., MacFarlane, M., & Cohen, G. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303399200 · Cited by 209 · see citing works
Isotype-Dependent Inhibition of Tumor Growth In Vivo by Monoclonal Antibodies to Death Receptor 4
Chuntharapai, A., Dodge, K., Grimmer, K., Schroeder, K. A., Marsters, S. A., Koeppen, H., Ashkenazi, A., & Kim, K. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.4891 · Cited by 201 · see citing works
Identity of differentiation inducing factor and tumour necrosis factor
Takeda, K., Iwamoto, S., Sugimoto, H., Takuma, T., Kawatani, N., Noda, M., Masaki, A., Morise, H., Arimura, H., & Konno, K. (1986) · Nature · doi:10.1038/323338a0 · Cited by 182 · see citing works
Kwon, B. S., Wang, S., Udagawa, N., Haridas, V., Lee, Z. H., Kim, K. K., Oh, K., Greene, J., Li, Y., Su, J. Y., et al. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.10.845 · Cited by 179 · see citing works
Self-citationPrimary structure of human lymphotoxin derived from 1788 lymphoblastoid cell line.
Aggarwal, B. B., Henzel, W. J., Moffat, B., Kohr, W. J., & Harkins, R. N. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89559-x · Cited by 170 · see citing works
Self-citationWielockx, B., Lannoy, K., Shapiro, S. D., Itoh, T., Itohara, S., Vandekerckhove, J. S., & Libert, C. (2001) · Nature Medicine · doi:10.1038/nm1101-1202 · Cited by 167 · see citing works
Shear, M. J., Turner, F. C., Perrault, A., & Shovelton, T. (1943) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/4.1.81 · Cited by 163 · see citing works
A Role for Fas in Negative Selection of Thymocytes In Vivo
Kishimoto, H., Surh, C. D., & Sprent, J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1427 · Cited by 161 · see citing works
Zhai, Y., Ni, J., Jiang, G., Lu, J., Xing, L., Lincoln, C., Carter, K. C., Janat, F., KOZAK, D., XU, S., et al. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.1.181 · Cited by 159 · see citing works
Self-citationFisher, M. J., Virmani, A. K., Wu, L., Aplenc, R., Harper, J. C., Powell, S. M., Rebbeck, T. R., Sidransky, D., Gazdar, A. F., & El‐Deiry, W. S. (2001) · PubMed · Cited by 143 · see citing works
Weiß, T., Grell, M., Siemienski, K., Mühlenbeck, F., Dürkop, H., Pfizenmaier, K., Scheurich, P., & Wajant, H. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.6.3136 · Cited by 134 · see citing works
Chen, Y., Molloy, S. S., Thomas, L., Gambee, J. E., Bächinger, H. P., Ferguson, B. M., Zonana, J., Thomas, G., & Morris, N. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131076098 · Cited by 124 · see citing works
Zheng, Y., Ouaaz, F., Bruzzo, P., Singh, V., Gerondakis, S., & Beg, A. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.4949 · Cited by 117 · see citing works
Lymphocyte in vitro Cytotoxicity: Lymphotoxins of Several Mammalian Species
Williams, T. W., & Granger, G. A. (1968) · Nature · doi:10.1038/2191076a0 · Cited by 115 · see citing works
Induction of TNF‐sensitive cellular phenotype by c‐Myc involves p53 and impaired NF‐κB activation
Klefström, J. T., Arighi, E., Littlewood, T., Jäättelä, M., Saksela, E., Evan, G. I., & Alitalo, K. K. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7382 · Cited by 114 · see citing works
Nagata, S. (1998) · Journal of Human Genetics · doi:10.1007/s100380050029 · Cited by 97 · see citing works
Kasof, G. M., Lu, J. J., Liu, D., Speer, B. S., Mongan, K. N., Gomes, B. C., & Lorenzi, M. V. (2001) · Oncogene · doi:10.1038/sj.onc.1204985 · Cited by 96 · see citing works
Inflammatory Mediators and the Failing Heart: A Translational Approach
Diwan, A., Tran, T. T., Misra, A., & Mann, D. L. (2003) · Current Molecular Medicine · doi:10.2174/1566524033361537 · Cited by 93 · see citing works
Tumour Necrosis Factor in Chronic Heart Failure
Bolger, A. P., & Anker, S. D. (2000) · Drugs · doi:10.2165/00003495-200060060-00002 · Cited by 86 · see citing works
Death Receptor Signaling Giving Life to Ectodermal Organs
Thesleff, I., & Mikkola, M. L. (2002) · Science Signaling · doi:10.1126/stke.2002.131.pe22 · Cited by 76 · see citing works
Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-α
Lauzurica, P., Martı́nez-Martı́nez, S., Marazuela, M., Arco, P. G., Martínez‐A, C., Sánchez‐Madrid, F., & Redondo, J. M. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199906)29:06 · Cited by 71 · see citing works
You, Z., Madrid, L. V., Saims, D., Sedivy, J. M., & Wang, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203213200 · Cited by 70 · see citing works
O'Malley, W. E., Achinstein, B., & Shear, M. J. (1962) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/29.6.1169 · Cited by 68 · see citing works
Couriel, D. R., Hicks, K. L., Giralt, S. A., & Champlin, R. E. (2000) · Current Opinion in Oncology · doi:10.1097/00001622-200011000-00011 · Cited by 65 · see citing works
Haridas, V., Shrivastava, A., Su, J. Y., Yu, G.-L., Ni, J., Liu, D., Chen, S.-F., Ni, Y., Ruben, S. M., Gentz, R., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1203059 · Cited by 60 · see citing works
Self-citationMukhopadhyay, A., Suttles, J., Stout, R. D., & Aggarwal, B. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105252200 · Cited by 60 · see citing works
Self-citationThe Role of TNF Receptor and TNF Superfamily Molecules in Organ Transplantation
Adams, A. B., Larsen, C. P., Pearson, T. C., & Newell, K. A. (2002) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2002.020104.x · Cited by 53 · see citing works
Algire, G. H., Legallais, F. Y., & ANDERSON, B. F. (1952) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/12.6.1279 · Cited by 47 · see citing works
Role of Defective Apoptosis in Type 1 Diabetes and Other Autoimmune Diseases
Hayashi, T. (2003) · Recent Progress in Hormone Research · doi:10.1210/rp.58.1.131 · Cited by 45 · see citing works
Aganna, E., Aksentijevich, I. A., Hitman, G. A., Kastner, D. L., Hoepelman, A. I. M., Posma, F. D., Ej, Z., & McDermott, M. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200573 · Cited by 45 · see citing works
Role of tumor necrosis factor on toxicity and cytokine production after isolated hepatic perfusion.
Lans, T. E., Bartlett, D. L., Libutti, S. K., Gnant, M., Liewehr, D. J., Venzon, D. J., Turner, E. M., & Alexander, H. R. (2001) · PubMed · Cited by 45 · see citing works
Frequent mutations of Fas gene in thyroid lymphoma.
Takakuwa, T., Dong, Z., Takayama, H., Matsuzuka, F., Nagata, S., & Aozasa, K. (2001) · PubMed · Cited by 44 · see citing works
Takayama, H., Takakuwa, T., Dong, Z., Nonomura, N., Okuyama, Ä., Nagata, S., & Aozasa, K. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780236 · Cited by 35 · see citing works
Takada, Y., & Aggarwal, B. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213237200 · Cited by 35 · see citing works
Self-citationO'Malley, W. E., Achinstein, B., & Shear, M. J. (1963) · PubMed · Cited by 28 · see citing works
Frequent Fas Gene Mutations in Testicular Germ Cell Tumors
Takayama, H., Takakuwa, T., Tsujimoto, Y., Tani, Y., Nonomura, N., Okuyama, Ä., Nagata, S., & Aozasa, K. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64219-8 · Cited by 28 · see citing works
CD40—CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)
Ramesh, N., Morio, T., Fuleihan, R., Worm, M., Horner, A. A., Tsitsikov, E. N., Castigli, E., & Geha, R. S. (1995) · Clinical Immunology and Immunopathology · doi:10.1016/s0090-1229(95)90252-x · Cited by 24 · see citing works
Structural and Biochemical Analysis of Signal Transduction by the TRAF Family of Adapter ProteinsPreprint
McWhirter, S. M., Pullen, S. S., WERNEBURG, B. G., Labadia, M. E., Ingraham, R. H., Crute, J. J., Kehry, M. R., & Alber, T. (1999) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1999.64.551 · Cited by 13 · see citing works
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Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842 · see citing works
Aggarwal, B. B., & Harikumar, K. B. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.010 · Cited by 2,043 · see citing works
Self-citationInto the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940 · see citing works
Tumour necrosis factor and cancer
Balkwill, F. R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2628 · Cited by 1,925 · see citing works
Molecular targets of dietary agents for prevention and therapy of cancer
Aggarwal, B. B., & Shishodia, S. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.02.009 · Cited by 1,757 · see citing works
Self-citationThe neuropathic pain triad: neurons, immune cells and glia
Scholz, J., & Woolf, C. J. (2007) · Nature Neuroscience · doi:10.1038/nn1992 · Cited by 1,738 · see citing works
Nuclear factor-κB: The enemy within
Aggarwal, B. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.003 · Cited by 1,289 · see citing works
Self-citationNF-κB activation by reactive oxygen species: Fifteen years later
Gloire, G., Legrand-Poels, S., & Piette, J. G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.04.011 · Cited by 1,540 · see citing works
TFOS DEWS II Management and Therapy Report
Jones, L., Downie, L. E., Korb, D. R., Benitez-del-Castillo, J., Dana, R., Deng, S. X., Dong, P. N., Geerling, G., Hida, R. Y., Liu, Y., et al. (2017) · The Ocular Surface · doi:10.1016/j.jtos.2017.05.006 · Cited by 1,437 · see citing works
ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF CURCUMIN
Menon, V. P., & Sudheer, A. R. (2007) · Springer eBooks · doi:10.1007/978-0-387-46401-5_3 · Cited by 1,407 · see citing works
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
Aggarwal, B. B., Bhardwaj, A., Aggarwal, R. S., Seeram, N. P., Shishodia, S., & Takada, Y. (2004) · PubMed · Cited by 1,383 · see citing works
Self-citationTNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES
Watts, T. H. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115839 · Cited by 1,353 · see citing works
Overview of cell death signaling pathways
Jin, Z., & El‐Deiry, W. S. (2005) · Cancer Biology & Therapy · doi:10.4161/cbt.4.2.1508 · Cited by 1,323 · see citing works
Inflammation and cancer: how hot is the link?
Aggarwal, B. B., Shishodia, S., Sandur, S. K., Pandey, M. K., & Sethi, G. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.06.029 · Cited by 1,312 · see citing works
Self-citationKaminska, B. (2005) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2005.08.017 · Cited by 1,285 · see citing works
Mechanisms of Cell Protection by Heme Oxygenase-1
Gozzelino, R., Jeney, V., & Soares, M. P. (2010) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.010909.105600 · Cited by 1,241 · see citing works
Regulation of NF-κB by TNF family cytokines
Hayden, M. S., & Ghosh, S. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.05.004 · Cited by 1,116 · see citing works
Inflammation, a Key Event in Cancer Development
Lu, H., Ouyang, W., & Huang, C. (2006) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-05-0261 · Cited by 1,031 · see citing works
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
Hamanaka, R. B., & Chandel, N. S. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.04.002 · Cited by 1,011 · see citing works
Regulation of tumour necrosis factor signalling: live or let die
Brenner, D., Blaser, H., & Mak, T. W. (2015) · Nature Reviews Immunology · doi:10.1038/nri3834 · Cited by 998 · see citing works
Essential function for the kinase TAK1 in innate and adaptive immune responses
Sato, S., Sanjo, H., Takeda, K., Ninomiya‐Tsuji, J., Yamamoto, M., Kawai, T., Matsumoto, K., Takeuchi, O., & Akira, S. (2005) · Nature Immunology · doi:10.1038/ni1255 · Cited by 974 · see citing works
Fundamental Mechanisms of Regulated Cell Death and Implications for Heart Disease
Re, D. P. D., Amgalan, D., Linkermann, A., Liu, Q., & Kitsis, R. N. (2019) · Physiological Reviews · doi:10.1152/physrev.00022.2018 · Cited by 979 · see citing works
The many roles of FAS receptor signaling in the immune system
Strasser, A., Jost, P. J., & Nagata, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.001 · Cited by 968 · see citing works
Nuclear factor-?B: its role in health and disease
Kumar, A., Takada, Y., Boriek, A., & Aggarwal, B. (2004) · Journal of Molecular Medicine · doi:10.1007/s00109-004-0555-y · Cited by 933 · see citing works
Self-citationZhao, J., Jitkaew, S., Cai, Z., Choksi, S., Li, Q., Luo, J., & Liu, Z.-G. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200012109 · Cited by 901 · see citing works
M2b macrophage polarization and its roles in diseases
Wang, L., Zhang, S.-X., Wu, H., Rong, X., & Guo, J. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru1018-378rr · Cited by 889 · see citing works
Aggarwal, B. B., Gupta, S. C., & Kim, J. H. (2012) · Blood · doi:10.1182/blood-2011-04-325225 · Cited by 877 · see citing works
Self-citationTNF-α/NF-κB/Snail pathway in cancer cell migration and invasion
Wu, Y., & Zhou, B. P. (2010) · British Journal of Cancer · doi:10.1038/sj.bjc.6605530 · Cited by 798 · see citing works
Tang, W., Lu, Y., Tian, Q.-Y., Zhang, Y., Guo, F.-J., Liu, G.-Y., Syed, N. M., Lai, Y., Lin, E. A., Kong, L., et al. (2011) · Science · doi:10.1126/science.1199214 · Cited by 761 · see citing works
Lymphoid organ development: from ontogeny to neogenesis
Drayton, D. L., Liao, S., Mounzer, R. H., & Ruddle, N. H. (2006) · Nature Immunology · doi:10.1038/ni1330 · Cited by 777 · see citing works
Popa, C. D., Netea, M. G., van Riel, P. L. C. M., van der Meer, J. W. M., & Stalenhoef, A. F. H. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r600021-jlr200 · Cited by 765 · see citing works
Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF
Fischer, R., & Maier, O. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2015/610813 · Cited by 744 · see citing works
Tumor necrosis factor and cancer, buddies or foes?
Wang, X., & Lin, Y. (2008) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2008.00889.x · Cited by 730 · see citing works
Dohan, D., Choukroun, J., Diss, A., Dohan, S. L., Dohan, A. J. J., Mouhyi, J., & Gogly, B. (2006) · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · doi:10.1016/j.tripleo.2005.07.010 · Cited by 717 · see citing works
TNF-α in Cancer Treatment: Molecular Insights, Antitumor Effects, and Clinical Utility
van Horssen, R., ten Hagen, T. L. M., & Eggermont, A. M. M. (2006) · The Oncologist · doi:10.1634/theoncologist.11-4-397 · Cited by 699 · see citing works
Galloway, J. B., Hyrich, K. L., Mercer, L., Dixon, W. G., Fu, B., Ustianowski, A., Watson, K. D., Lunt, M., Symmons, D. P. M., & on behalf of the British Society for Rheumatology Biologics Register (2010) · Lara D. Veeken · doi:10.1093/rheumatology/keq242 · Cited by 678 · see citing works
The Function of Fish Cytokines
Zou, J., & Secombes, C. J. (2016) · Biology · doi:10.3390/biology5020023 · Cited by 679 · see citing works
D'Mello, C., Le, T., & Swain, M. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3567-08.2009 · Cited by 675 · see citing works
The role of IL-1β and TNF-α in intervertebral disc degeneration
Wang, Y., Che, M., Xin, J., Zheng, Z. J., Li, J., & Zhang, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110660 · Cited by 626 · see citing works
CD4+ T-cell help controls CD8+ T-cell memory via TRAIL-mediated activation-induced cell death
Janssen, E. M., Droin, N. M., Lemmens, E. E., Pinkoski, M. J., Bensinger, S. J., Ehst, B. D., Griffith, T. S., Green, D. R., & Schoenberger, S. P. (2005) · Nature · doi:10.1038/nature03337 · Cited by 619 · see citing works
The signal pathways and treatment of cytokine storm in COVID-19
Yang, L., Xie, X., Tu, Z., Fu, J., Xu, D., & Zhou, Y. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00679-0 · Cited by 599 · see citing works
Regulation of Apoptosis by Alternative Pre-mRNA Splicing
Schwerk, C., & Schulze‐Osthoff, K. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.05.026 · Cited by 595 · see citing works
Role of TNFα in pulmonary pathophysiology
Mukhopadhyay, S., Hoidal, J. R., & Mukherjee, T. K. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-125 · Cited by 580 · see citing works
Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis
Petersen, S. L., Wang, L., Yalcin-Chin, A., Li, L., Peyton, M., Minna, J. D., Harran, P. G., & Wang, X. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.08.029 · Cited by 572 · see citing works
Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy
von Karstedt, S., Montinaro, A., & Walczak, H. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2017.28 · Cited by 556 · see citing works
Chen, X., Bäumel, M., Männel, D. N., Howard, O. M. Z., & Oppenheim, J. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.1.154 · Cited by 550 · see citing works
Functions and mechanisms of action of CCN matricellular proteins
Chen, C.-C., & Lau, L. F. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.07.025 · Cited by 549 · see citing works
Molecular principles of hair follicle induction and morphogenesis
Schmidt‐Ullrich, R., & Paus, R. (2005) · BioEssays · doi:10.1002/bies.20184 · Cited by 549 · see citing works
Zhu, L., Nie, L., Zhu, G., Xiang, L., & Shao, J.-Z. (2012) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2012.04.001 · Cited by 550 · see citing works
How Tolerogenic Dendritic Cells Induce Regulatory T Cells
Maldonado, R., & von Andrian, U. H. (2010) · Advances in immunology · doi:10.1016/b978-0-12-380995-7.00004-5 · Cited by 543 · see citing works
Peart, M. J., Smyth, G. K., van Laar, R. K., Bowtell, D. D. L., Richon, V. M., Marks, P. A., Holloway, A. J., & Johnstone, R. W. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0500369102 · Cited by 538 · see citing works
Cruceriu, D., Baldasici, O., Bălăcescu, O., & Berindan‐Neagoe, I. (2020) · Cellular Oncology · doi:10.1007/s13402-019-00489-1 · Cited by 531 · see citing works
BAFF, APRIL and their receptors: Structure, function and signaling
Bossen, C., & Schneider, P. (2006) · Seminars in Immunology · doi:10.1016/j.smim.2006.04.006 · Cited by 523 · see citing works
Targeting Inflammation-Induced Obesity and Metabolic Diseases by Curcumin and Other Nutraceuticals
Aggarwal, B. B. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104755 · Cited by 471 · see citing works
Self-citationInsulin resistance associated to obesity: the link TNF-alpha
Nieto-Vázquez, I., Fernández‐Veledo, S., Kramer, D., Vila‐Bedmar, R., García‐Guerra, L., & Lorenzo, M. (2008) · Archives of Physiology and Biochemistry · doi:10.1080/13813450802181047 · Cited by 475 · see citing works
Nanobodies as therapeutics: big opportunities for small antibodies
Steeland, S., Vandenbroucke, R. E., & Libert, C. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.04.003 · Cited by 470 · see citing works
TNF: A master switch for inflammation to cancer
Sethi, G. (2008) · Frontiers in Bioscience · doi:10.2741/3066 · Cited by 458 · see citing works
Regulation of gene-activation pathways by PIAS proteins in the immune system
Shuai, K., & Liu, B. (2005) · Nature reviews. Immunology · doi:10.1038/nri1667 · Cited by 447 · see citing works
TNF receptor 2 pathway: drug target for autoimmune diseases
Faustman, D., & Davis, M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3030 · Cited by 446 · see citing works
Nuclear factor-kappa B signaling in skeletal muscle atrophy
Li, H., Malhotra, S., & Kumar, A. (2008) · Journal of Molecular Medicine · doi:10.1007/s00109-008-0373-8 · Cited by 442 · see citing works
TLR-4, IL-1R and TNF-R signaling to NF-κB: variations on a common theme
Verstrepen, L., Bekaert, T., Chau, T., Tavernier, J. H., Chariot, A., & Beyaert, R. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8064-8 · Cited by 440 · see citing works
Signal transduction by tumor necrosis factor receptors
Cabal‐Hierro, L., & Lazo, P. S. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.02.006 · Cited by 435 · see citing works
C1q and tumor necrosis factor superfamily: modularity and versatility
Kishore, U., Gaboriaud, C., Waters, P. J., Shrive, A. K., Greenhough, T. J., Reid, K. B. M., Sim, R. B., & Arlaud, G. J. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.08.006 · Cited by 437 · see citing works
Transcription Factor NF‐κB: A Sensor for Smoke and Stress Signals
Ahn, K., & Aggarwal, B. B. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1352.026 · Cited by 432 · see citing works
Self-citationCarrier, Y., Ma, H., Ramón, H. E., Napierata, L., Small, C. G., O’Toole, M., Young, D. A., Fouser, L. A., Nickerson‐Nutter, C. L., Collins, M. A., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.234 · Cited by 425 · see citing works
CD27 and CD70 in T cell and B cell activation
Borst, J. G., Hendriks, J., & Xiao, Y. (2005) · Current Opinion in Immunology · doi:10.1016/j.coi.2005.04.004 · Cited by 420 · see citing works
Necroptosis in health and diseases
Zhou, W., & Yuan, J. (2014) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2014.07.013 · Cited by 414 · see citing works
Role of Curcumin in Cancer Therapy
Shishodia, S., Chaturvedi, M. M., & Aggarwal, B. B. (2007) · Current Problems in Cancer · doi:10.1016/j.currproblcancer.2007.04.001 · Cited by 413 · see citing works
Self-citationLin, Y., Choksi, S., Shen, H., Yang, Q., Hur, G. M., Kim, Y. S., Tran, J. H., Nedospasov, S. A., & Liu, Z.-G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313141200 · Cited by 411 · see citing works
Mehta, A. K., Gracias, D. T., & Croft, M. (2016) · Cytokine · doi:10.1016/j.cyto.2016.08.003 · Cited by 404 · see citing works
Bubici, C., Papa, S., Dean, K., & Franzoso, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209936 · Cited by 399 · see citing works
Mor, A., Abramson, S. B., & Pillinger, M. H. (2005) · Clinical Immunology · doi:10.1016/j.clim.2004.12.009 · Cited by 399 · see citing works
Assessment of Variability in the SOMAscan Assay
Candia, J., Cheung, F., Kotliarov, Y., Fantoni, G., Sellers, B. A., Griesman, T., Huang, J., Stuccio, S., Zingone, A., Ryan, B. M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14755-5 · Cited by 399 · see citing works
Curcumin: an orally bioavailable blocker of TNF and other pro‐inflammatory biomarkers
Aggarwal, B. B., Gupta, S. C., & Sung, B. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12131 · Cited by 401 · see citing works
Self-citationClassical and Paradoxical Effects of TNF-α on Bone Homeostasis
Osta, B., Benedetti, G., & Miossec, P. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00048 · Cited by 391 · see citing works
Zhang, Z., Zhao, L. Q., Zhou, X., Meng, X., & Zhou, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1098725 · Cited by 387 · see citing works
NF-κB signaling in cerebral ischemia
Ridder, D. A., & Schwaninger, M. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.07.007 · Cited by 387 · see citing works
The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy
Lin, Y., Bai, L., Chen, W., & Xu, S. (2009) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903431069 · Cited by 380 · see citing works
Rothman, N., Skibola, C. F., Wang, S., Morgan, G. J., Lan, Q., Smith, M. T., Spinelli, J. J., Willett, E. V., de Sanjosé, S., Cocco, P., et al. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70434-4 · Cited by 379 · see citing works
Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 389 · see citing works
Fas death receptor signalling: roles of Bid and XIAP
Kaufmann, T., Strasser, A., & Jost, P. J. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.121 · Cited by 374 · see citing works
The Drosophila IMD pathway in the activation of the humoral immune response
Kleino, A., & Silverman, N. S. (2013) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2013.05.014 · Cited by 366 · see citing works
Pathophysiology of Graft-Versus-Host Disease
Ferrara, J. L. M., & Reddy, P. R. (2006) · Seminars in Hematology · doi:10.1053/j.seminhematol.2005.09.001 · Cited by 364 · see citing works
Khairova, R. A., Machado-Vieira, R., Du, J., & Manji, H. K. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709009924 · Cited by 350 · see citing works
Necroptosis in development and diseasesPreprint
Shan, B., Pan, H., Najafov, A., & Yuan, J. (2018) · Genes & Development · doi:10.1101/gad.312561.118 · Cited by 345 · see citing works
Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence
Espín-Palazón, R., Stachura, D. L., Campbell, C. A., García-Moreno, D., Del Cid, N., Kim, A. D., Candel, S., Meseguer, J., Mulero, V., & Traver, D. (2014) · Cell · doi:10.1016/j.cell.2014.10.031 · Cited by 333 · see citing works
Drugs for Autoimmune Inflammatory Diseases: From Small Molecule Compounds to Anti-TNF Biologics
Li, P., Zheng, Y., & Chen, X. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00460 · Cited by 349 · see citing works
Cyclometalated iridium(III) luminescent complexes in therapy and phototherapy
Zamora, A., Vigueras, G., Rodrı́guez, V., Santana, M. D., & Ruiz, J. (2018) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.01.010 · Cited by 346 · see citing works
Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin
Hosseinzadeh, A., Kamrava, S. K., Joghataei, M. T., Darabi, R., Shakeri‐Zadeh, A., Shahriari, M., Reiter, R. J., Ghaznavi, H., & Mehrzadi, S. (2016) · Journal of Pineal Research · doi:10.1111/jpi.12362 · Cited by 345 · see citing works
Cytokine-mediated communication: a quantitative appraisal of immune complexity
Altan-Bonnet, G. Y., & Mukherjee, R. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0131-x · Cited by 343 · see citing works
Yao, D., Dong, M., Dai, C., & Wu, S. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz149 · Cited by 337 · see citing works
CCN1/CYR61: the very model of a modern matricellular protein
Lau, L. F. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0778-3 · Cited by 338 · see citing works
Chen, X., Subleski, J. J., Kopf, H., Howard, O. M. Z., Männel, D. N., & Oppenheim, J. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6467 · Cited by 336 · see citing works
Multifaceted link between cancer and inflammation
Sethi, G., Shanmugam, M. K., Ramachandran, L., Kumar, A. P., & Tergaonkar, V. (2011) · Bioscience Reports · doi:10.1042/bsr20100136 · Cited by 333 · see citing works
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Sanmarco, L. M., Wheeler, M. A., Gutiérrez-Vázquez, C., Polonio, C. M., Linnerbauer, M., Pinho-Ribeiro, F. A., Li, Z., Giovannoni, F., Batterman, K. V., Scalisi, G., et al. (2021) · Nature · doi:10.1038/s41586-020-03116-4 · Cited by 331 · see citing works
Shi, J., & Sun, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01849 · Cited by 330 · see citing works
Human malarial disease: a consequence of inflammatory cytokine release
Clark, I. A., Budd, A. C., Alleva, L. M., & Cowden, W. B. (2006) · Malaria Journal · doi:10.1186/1475-2875-5-85 · Cited by 318 · see citing works
Cytokine Research in Depression: Principles, Challenges, and Open Questions
Himmerich, H., Patsalos, O., Lichtblau, N., Ibrahim, M. A. A., & Dalton, B. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00030 · Cited by 313 · see citing works
Ubiquitination of RIP1 Regulates an NF-κB-Independent Cell-Death Switch in TNF Signaling
O'Donnell, M. A., Legarda-Addison, D., Skountzos, P., Yeh, W. C., & Ting, A. T. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.027 · Cited by 310 · see citing works
- Authors
- Aggarwal, B. B.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Aggarwal, Bharat B.
- ORCID
- Aggarwal, Bharat B.
- Venue
- Nature Reviews Immunology
- Published
- 2003-09
- Volume
- 3
- Issue
- 9
- Pages
- 745-756
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2095013915
- Cited by
- 2,793
- References
- 124
- Citations by year
- 2026: 74 · 2025: 107 · 2024: 82 · 2023: 121 · 2022: 125 · 2021: 114 · 2020: 132 · 2019: 113 · 2018: 114 · 2017: 130 · 2016: 108 · 2015: 142 · 2014: 128 · 2013: 116 · 2012: 159
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- TNF superfamily, TNF-α, TNF receptor, signaling pathways, carcinogenesis, graft rejection, septic shock, viral replication, bone resorption, rheumatoid arthritis, diabetes mellitus, apoptosis, TNF-alpha inhibitors, autoimmune disease, cytokines
- MeSH terms
- Animals, Autoimmune Diseases, Carrier Proteins, Humans, Ligands, Lymphotoxin-alpha, Membrane Proteins, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Receptors, Tumor Necrosis Factor, Mice
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