The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide
Abstract
Motivated by the success of using graphene oxide (GO) as a nanofiller of composites, there is a drive to search for this new kind of carbon material as a reinforcing phase in biocomposites. In the present work, graphene oxide and chitosan (CS) functionalized graphene oxide were introduced as templates to fabricate hydroxyapatite (HA) using a facile solution-based in situ synthesis method, and GO-HA and CS-GO-HA nanocomposites were successfully prepared for the first time. It was found that the spindle like HA nanoparticles with a diameter of about 27 ± 7 nm and a length around 150 ± 25 nm were decorated randomly and strongly on the surface or aggregated at the edges of the pristine and chitosan functionalized GO matrix. Compared with HA, the prepared GO-based HA nanocomposites displayed an increased elastic modulus and hardness. The in vitro cytotoxicity of the prepared nanocomposites was investigated using CCK-8 assay on murine fibroblast L-929 cell line and human osteoblast-like MG-63 cell line, respectively. Both of the nanocomposites exhibited a high cell proliferation rate for L-929 and MG-63, and the CS-GO-HA could provide significantly higher cell viability and alkaline phosphatase activity compared to the GO-HA composite. These findings may provide new prospects for utilizing the GO-based hydroxyapatite biocomposites in bone repair, bone augmentation, as well as coating of biomedical implants and broaden the application of GO sheets in biological areas.
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Cites
The chemistry of graphene oxide
Dreyer, D. R., Park, S., Bielawski, C. W., & Ruoff, R. S. (2010) · Chem. Soc. Rev. · doi:10.1039/b917103g · Cited by 11,653
Nanocrystal Growth on Graphene with Various Degrees of Oxidation
Wang, H., Robinson, J. T., Diankov, G., & Dai, H. (2010) · Journal of the American Chemical Society · doi:10.1021/ja100329d · Cited by 530
Liu, H., Xi, P., Xie, G., Shi, Y., Hou, F., Huang, L., Chen, F., Zeng, Z., Shao, C., & Wang, J. (2012) · The Journal of Physical Chemistry C · doi:10.1021/jp2102226 · Cited by 207
Cited by
Baradaran, S., Moghaddam, E., Basirun, W. J., Mehrali, M., Sookhakian, M., Hamdi, M., Moghaddam, M. R. N., & Alias, Y. (2014) · Carbon · doi:10.1016/j.carbon.2013.11.054 · Cited by 340
Enhanced Osteogenesis by Reduced Graphene Oxide/Hydroxyapatite Nanocomposites
Lee, J. H., Shin, Y. C., Lee, S.-M., Jin, O. S., Kang, S. H., Hong, S. W., Jeong, C.-M., Huh, J. B., & Han, D.-W. (2015) · Scientific Reports · doi:10.1038/srep18833 · Cited by 258
Metadata
- Authors
- Li, M., Wang, Y., Liu, Q., Li, Q., Cheng, Y., Zheng, Y., Xi, T., & Wei, S.
- Venue
- J. Mater. Chem. B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 1
- Issue
- 4
- Pages
- 475-484
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W2115473959
- Cited by
- 246
- References
- 3
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Li, M., Wang, Y., Liu, Q., Li, Q., Cheng, Y., Zheng, Y., Xi, T., & Wei, S. (2013). In situ synthesis and biocompatibility of nano hydroxyapatite on pristine and chitosan functionalized graphene oxide. J. Mater. Chem. B. https://doi.org/10.1039/c2tb00053a
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