Simultaneous Reduction and Surface Functionalization of Graphene Oxide for Hydroxyapatite Mineralization
Open accessAbstract
In this study, we present the synthesis of reduced graphene oxide/hydroxyapatite (RGO/HA) hybrid materials by an environmental-friendly route. Graphene oxide (GO) was first simultaneously reduced and surface functionalized by one-step oxidative polymerization of dopamine (PDA). The bioinspired surface was further used for biomimetic mineralization of hydroxyapatite. When incubated in a simulated body fluid (SBF), the PDA layer enabled efficient interaction between the RGO surface and the mineral ions to improve the bioactivity, promoted the formation of the HA nanoparticles. A detailed structural and morphological characterization of the mineralized composite was performed. The HA-based hybrid materials exhibited no cytotoxic effect on L929 fibroblast cells, showing potential capacity of being a scaffold material for bone tissue regeneration and implantation. This facile strategy also can be a useful platform for other RGO-based nanocomposites.
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Hybrid RGO-HA demonstrated great biocompatibility with L929 fibroblast cells.
“The hybrid RGO-HA demonstrated great biocompatibility with L929 fibroblast cells.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [77]
With the combination of unique RGO and PDA-HA properties, the hybrid material possesses great potential for implantation and other biomedical purposes.
“With the combination of unique RGO and PDA-HA properties, this hybrid material possesses great potential, not only for implantation but also for other biomedical purposes.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [77]
L929 cells showed an increase in cellular proliferation by 120% (RGO-PDA) and 116% (RGO/HA), suggesting that these materials have the least cytotoxicity.
“These cells showed an increase in cellular proliferation by 120% (RGO-PDA) and 116% (RGO/HA), suggesting that these types of materials have the least cytotoxicity.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [77]
HA biomineral generated by pHAF on a reduced RGO surface had a similar chemical composition to biological apatite in the human body.
“Impressively, the HA biomineral generated by this method had a similar chemical composition to biological apatite in the human body.”
From Strategies for Using Polydopamine to Induce Biomineralization of Hydroxyapatite on Implant Materials for Bone Tissue Engineering (2020) · cites this paper as [77]
Cites
Mussel‐Inspired Polydopamine Coating as a Universal Route to Hydroxyapatite Crystallization
Ryu, J., Ku, S. H., Lee, H., & Park, C. B. (2010) · Advanced Functional Materials · doi:10.1002/adfm.200902347 · Cited by 778 · see citing works
Metals and the Integrity of a Biological Coating: The Cuticle of Mussel Byssus
Holten-Andersen, N., Mates, T. E., Toprak, M. S., Stucky, G. D., Zok, F. W., & Waite, J. H. (2009) · Langmuir · doi:10.1021/la8027012 · Cited by 216 · see citing works
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Kaushik, N., Nhat Nguyen, L., Kim, J. H., Choi, E. H., & Kumar Kaushik, N. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186544 · Cited by 76 · see citing works
“implemented pHAF methods to effectively generate HA on a reduced RGO surface [77].”
Method
- Authors
- Liu, H., Xi, P., Xie, G., Shi, Y., Hou, F., Huang, L., Chen, F., Zeng, Z., Shao, C., & Wang, J.
- Affiliations
- State Key Laboratory of Applied Organic Chemistry (CN)
- National University of Defense Technology (CN)
- Corresponding author
- Zeng, Zhengzhi
- ORCID
- Venue
- The Journal of Physical Chemistry C
- Publisher
- American Chemical Society (ACS)
- Published
- 2012-01-26
- Volume
- 116
- Issue
- 5
- Pages
- 3334-3341
- ISSN
- 1932-7447 (ISSN-L)
- 1932-7455
- OpenAlex
- W2313815402
- Cited by
- 207
- References
- 2
- Citations by year
- 2025: 3 · 2024: 6 · 2023: 10 · 2022: 10 · 2021: 13 · 2020: 15 · 2019: 19 · 2018: 27 · 2017: 16 · 2016: 24 · 2015: 20 · 2014: 19 · 2013: 16 · 2012: 9
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- green
- 202.201.7.4:8080
- Licence
- cc-by-nc-nd
- Locations
- The Journal of Physical Chemistry C (publishedVersion)
- Lanzhou University Institutional Repository (submittedVersion, cc-by-nc-nd)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Engineering › Biomedical Engineering › Graphene and Nanomaterials Applications
- Physical Sciences › Materials Science › Materials Chemistry › Graphene research and applications
- Keywords
- reduced graphene oxide, hydroxyapatite, biomimetic mineralization, surface functionalization, simulated body fluid, bioactivity (biomaterials), bone regeneration, biocompatibility, L929 fibroblasts, bone scaffolds
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