The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Tumour targeting with radiometals for diagnosis and therapy
Abstract
Use of radiometals in nuclear oncology is a rapidly growing field and encompasses a broad spectrum of radiotracers for imaging via PET (positron emission tomography) or SPECT (single-photon emission computed tomography) and therapy via α, β(-), or Auger electron emission. This feature article opens with a brief introduction to the imaging and therapy modalities exploited in nuclear medicine, followed by a discussion of the multi-component strategy used in radiopharmaceutical development, known as the bifunctional chelate (BFC) method. The modular assembly is dissected into its individual components and each is discussed separately. The concepts and knowledge unique to metal-based designs are outlined, giving insight into how these radiopharmaceuticals are evaluated for use in vivo. Imaging nuclides (64)Cu, (68)Ga, (86)Y, (89)Zr, and (111)In, and therapeutic nuclides (90)Y, (177)Lu, (225)Ac, (213)Bi, (188)Re, and (212)Pb will be the focus herein. Finally, key examples have been extracted from the literature to give the reader a sense of breadth of the field.
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Cites
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Synthesis of 11C, 18F, 15O, and 13N Radiolabels for Positron Emission Tomography
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Potential Technetium Small Molecule Radiopharmaceuticals
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Radiometal-Labeled Agents (Non-Technetium) for Diagnostic Imaging
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PET imaging with 89Zr: From radiochemistry to the clinic
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Copper radionuclides and radiopharmaceuticals in nuclear medicine
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Radiometals for Combined Imaging and Therapy
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Cited by
Matching chelators to radiometals for radiopharmaceuticals
Price, E. W., & Orvig, C. (2014) · Chem. Soc. Rev. · doi:10.1039/c3cs60304k · Cited by 1,018
Self-citationProduction of 177Lu for Targeted Radionuclide Therapy: Available Options
Dash, A., Pillai, M. R. A., & Knapp, F. F. (2015) · Nuclear Medicine and Molecular Imaging · doi:10.1007/s13139-014-0315-z · Cited by 386
Potent candidates for Targeted Auger Therapy: Production and radiochemical considerations
Filosofov, D., Kurakina, E., & Radchenko, V. (2021) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2020.12.001 · Cited by 341
Development of 225Ac Radiopharmaceuticals: TRIUMF Perspectives and Experiences
Robertson, A. K. H., Ramogida, C. F., Schaffer, P., & Radchenko, V. (2018) · Current Radiopharmaceuticals · doi:10.2174/1874471011666180416161908 · Cited by 202
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Metadata
- Authors
- Ramogida, C. F., & Orvig, C.
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2013
- Volume
- 49
- Issue
- 42
- Pages
- 4720
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2082614986
- Cited by
- 255
- References
- 64
- FWCI
- 17.83
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
