The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Measuring single cell mass, volume, and density with dual suspended microchannel resonators
Open accessAbstract
Cell size, measured as either volume or mass, is a fundamental indicator of cell state. Far more tightly regulated than size is density, the ratio between mass and volume, which can be used to distinguish between cell populations even when volume and mass appear to remain constant. Here we expand upon a previous method for measuring cell density involving a suspended microchannel resonator (SMR). We introduce a new device, the dual SMR, as a high-precision instrument for measuring single-cell mass, volume, and density using two resonators connected by a serpentine fluidic channel. The dual SMR designs considered herein demonstrate the critical role of channel geometry in ensuring proper mixing and damping of pressure fluctuations in microfluidic systems designed for precision measurement. We use the dual SMR to compare the physical properties of two well-known cancer cell lines: human lung cancer cell H1650 and mouse lymphoblastic leukemia cell line L1210.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Weighing of biomolecules, single cells and single nanoparticles in fluid
Burg, T. P., Godin, M., Knudsen, S. M., Shen, W., Carlson, G., Foster, J. S., Babcock, K., & Manalis, S. R. (2007) · Nature · doi:10.1038/nature05741 · Cited by 1,213
Self-citationOptimizing Optical Flow Cytometry for Cell Volume-Based Sorting and Analysis
Tzur, A., Moore, J. K., Jorgensen, P., Shapiro, H. M., & Kirschner, M. W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016053 · Cited by 184
Cited by
Padovan-Merhar, O., Nair, G. P., Biaesch, A. G., Mayer, A., Scarfone, S., Foley, S. W., Wu, A. R., Churchman, L. S., Singh, A., & Raj, A. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.03.005 · Cited by 451
Characterizing Cellular Biophysical Responses to Stress by Relating Density, Deformability, and Size
Byun, S., Hecht, V. C., & Manalis, S. R. (2015) · Biophysical Journal · doi:10.1016/j.bpj.2015.08.038 · Cited by 34
Self-citationResource allocation in mammalian systems
Baghdassarian, H. M., & Lewis, N. E. (2024) · Biotechnology Advances · doi:10.1016/j.biotechadv.2023.108305 · Cited by 17
Integrative characterization of the near‐minimal bacterium Mesoplasma florum
Matteau, D., Lachance, J., Grenier, F., Gauthier, S., Daubenspeck, J. M., Dybvig, K., Garneau, D., Knight, T. F., Jacques, P., & Rodrigue, S. (2020) · Molecular Systems Biology · doi:10.15252/msb.20209844 · Cited by 16
“Measuring the total mass of a cell requires specialized equipment and can be very challenging, especially for small cells (Bryan et al , 2014; Zhao et al , 2014; Rahman et al , 2015).”
Metadata
- Authors
- Bryan, A. K., Hecht, V. C., Shen, W., Payer, K., Grover, W. H., & Manalis, S. R.
- Venue
- Lab Chip
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 14
- Issue
- 3
- Pages
- 569-576
- ISSN
- 1473-0189 (ISSN-L)
- 1473-0197
- OpenAlex
- W2064460491
- Cited by
- 185
- References
- 2
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Measuring single cell mass, volume, and density with dual suspended microchannel resonators. https://app.cochat.ai/papers/10.1039/c3lc51022k
- The paper
- Bryan, A. K., Hecht, V. C., Shen, W., Payer, K., Grover, W. H., & Manalis, S. R. (2014). Measuring single cell mass, volume, and density with dual suspended microchannel resonators. Lab Chip. https://doi.org/10.1039/c3lc51022k
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
