The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Polymerization-Induced Self-Assembly (PISA) – control over the morphology of nanoparticles for drug delivery applications
Abstract
In this paper, we describe the synthesis of asymmetric functional POEGMA-b-P(ST-co-VBA) copolymers in methanol, yielding in one-pot polymerization a range of nanoparticle morphologies, including spherical micelles, worm-like, rod-like micelles and vesicles. The presence of the aldehyde group was then exploited to form crosslinks or to conjugate chemotherapy compounds, such as doxorubicin, via pH-breakable bonds (Schiff base or imine) directly to the preformed nanoparticles. The influence of the nanoparticle morphologies on the MCF-7 breast cancer cell line uptake was investigated using flow cytometry and confocal microscopy. Finally, the IC50 of DOX, following nanoparticle delivery, was studied showing significant influence of the nanoparticle carrier morphology on therapeutic efficacy for breast cancer.
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Cites
The effect of particle design on cellular internalization pathways
Gratton, S. E. A., Ropp, P. A., Pohlhaus, P. D., Luft, J. C., Madden, V. J., Napier, M. E., & DeSimone, J. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801763105 · Cited by 2,918
Design of polymeric nanoparticles for biomedical delivery applications
Elsabahy, M., & Wooley, K. L. (2012) · Chemical Society Reviews · doi:10.1039/c2cs15327k · Cited by 1,717
Cited by
The Effect of Nanoparticle Size on In Vivo Pharmacokinetics and Cellular Interaction
Hoshyar, N., Gray, S., Han, H., & Bao, G. (2016) · Nanomedicine · doi:10.2217/nnm.16.5 · Cited by 1,990
The importance of nanoparticle shape in cancer drug delivery
Truong, N. P., Whittaker, M. R., Mak, C. W., & Davis, T. P. (2015) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.950564 · Cited by 594
Self-citationControlled/Living Radical Polymerization in Dispersed Systems: An Update
Zetterlund, P. B., Thickett, S. C., Perrier, S., Bourgeat-Lami, E., & Lansalot, M. (2015) · Chemical Reviews · doi:10.1021/cr500625k · Cited by 485
Entry of nanoparticles into cells: the importance of nanoparticle properties
Zhao, J., & Stenzel, M. H. (2018) · Polymer Chemistry · doi:10.1039/c7py01603d · Cited by 391
Tritschler, U., Pearce, S., Gwyther, J., Whittell, G. R., & Manners, I. (2017) · Macromolecules · doi:10.1021/acs.macromol.6b02767 · Cited by 375
Metadata
- Authors
- Karagoz, B., Esser, L., Duong, H. T., Basuki, J. S., Boyer, C., & Davis, T. P.
- Venue
- Polym. Chem.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 5
- Issue
- 2
- Pages
- 350-355
- ISSN
- 1759-9954 (ISSN-L)
- 1759-9962
- OpenAlex
- W2064519977
- Cited by
- 328
- References
- 2
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Karagoz, B., Esser, L., Duong, H. T., Basuki, J. S., Boyer, C., & Davis, T. P. (2014). Polymerization-Induced Self-Assembly (PISA) – control over the morphology of nanoparticles for drug delivery applications. Polym. Chem. https://doi.org/10.1039/c3py01306e
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