The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cytotoxicity of nanoscaled metal–organic frameworks
Open accessAbstract
A series of fourteen porous Metal–Organic Frameworks (MOFs) with different compositions (Fe, Zn, and Zr; carboxylates or imidazolates) and structures have been successfully synthesised at the nanoscale and fully characterised by XRPD, FTIR, TGA, N2 porosimetry, TEM, DLS and ζ-potential. Their toxicological assessment was performed using two different cell lines: human epithelial cells from foetal cervical carcinoma (HeLa) and murine macrophage cell line (J774). It appears that MOF nanoparticles (NPs) exhibit low cytotoxicity, comparable to those of other commercialised nanoparticulate systems, the less toxic being the Fe carboxylate and the more toxic being the zinc imidazolate NPs. The cytotoxicity values, higher in J774 cells than in HeLa cells, are mainly function of their composition and cell internalisation capacity. Finally, cell uptake of one of the most relevant Fe-MOF-NPs for drug vectorisation has been investigated by confocal microscopy studies, and indicates a faster kinetics of cell penetration within J774 compared to HeLa cells.
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Hentze, M. W., Muckenthaler, M. U., & Andrews, N. C. (2004) · Cell · doi:10.1016/s0092-8674(04)00343-5 · Cited by 1,736
Brunner, T. J., Wick, P., Manser, P., Spohn, P., Grass, R. N., Limbach, L. K., Bruinink, A., & Stark, W. J. (2006) · Environmental Science & Technology · doi:10.1021/es052069i · Cited by 1,385
Cited by
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Application of zirconium MOFs in drug delivery and biomedicine
Abánades Lázaro, I., & Forgan, R. S. (2019) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2018.09.009 · Cited by 678
Toxicity of metal–organic framework nanoparticles: from essential analyses to potential applications
Ettlinger, R., Lächelt, U., Gref, R., Horcajada, P., Lammers, T., Serre, C., Couvreur, P., Morris, R. E., & Wuttke, S. (2022) · Chemical Society Reviews · doi:10.1039/d1cs00918d · Cited by 423
Self-citationBiocompatibility and biodegradability of metal organic frameworks for biomedical applications
Singh, N., Qutub, S., & Khashab, N. M. (2021) · Journal of Materials Chemistry B · doi:10.1039/d1tb01044a · Cited by 303
Wuttke, S., Lismont, M., Escudero, A., Rungtaweevoranit, B., & Parak, W. J. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.01.025 · Cited by 286
Metadata
- Authors
- Tamames-Tabar, C., Cunha, D., Imbuluzqueta, E., Ragon, F., Serre, C., Blanco-Prieto, M. J., & Horcajada, P.
- Venue
- J. Mater. Chem. B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014
- Volume
- 2
- Issue
- 3
- Pages
- 262-271
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W2041270553
- Cited by
- 426
- References
- 2
- FWCI
- 7.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Tamames-Tabar, C., Cunha, D., Imbuluzqueta, E., Ragon, F., Serre, C., Blanco-Prieto, M. J., & Horcajada, P. (2014). Cytotoxicity of nanoscaled metal–organic frameworks. J. Mater. Chem. B. https://doi.org/10.1039/c3tb20832j
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