Allicin protects spinal cord neurons from Glutamate-induced oxidative stress through regulating the heat shock protein 70/inducible nitric oxide synthase pathway
Abstract
We demonstrate that allicin may be used as an effective treatment for spinal cord injury, and that the potential underlying mechanism involves HSP70/iNOS pathway-mediated inhibition of oxidative stress.
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Allicin has a protective effect on ischemic or traumatic neuronal damage controlled by apoptosis and oxidative stress pathways.
“Recently, allicin has been shown to have a protective effect on ischemic or traumatic neuronal damage controlled by apoptosis and oxidative stress pathways [105].”
From Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review (2020) · cites this paper as [105]
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Therapeutic roles of plants for 15 hypothesised causal bases of Alzheimer’s disease
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- Authors
- Liu, S.-G., Ren, P.-Y., Wang, G.-Y., Yao, S.-X., & He, X.-J.
- Affiliations
- Xi'an Honghui Hospital (CN)
- Department of Neurosurgery
- Department of Orthopaedics
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2015
- Volume
- 6
- Issue
- 1
- Pages
- 320-329
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W1972851617
- Cited by
- 56
- References
- 64
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 7 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 4
- FWCI
- 5.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Garlic and Onion Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
- Keywords
- allicin, spinal cord injury, glutamate excitotoxicity, oxidative stress, HSP70, inducible nitric oxide synthase, neuronal apoptosis, neuroprotection, garlic, reactive oxygen species, lipid peroxidation, antioxidant enzymes, neuronal NOS
- MeSH terms
- Animals, Animals, Newborn, Antioxidants, Cell Survival, Cells, Cultured, Disulfides, Embryo, Mammalian, Gene Expression Regulation, Nerve Tissue Proteins, Neurons, Spinal Cord, Sulfinic Acids, Lipid Peroxidation, Apoptosis, Reactive Oxygen Species, Oxidative Stress, Neuroprotective Agents, Glutamic Acid, HSP70 Heat-Shock Proteins, RNA Interference, Rats, Nitric Oxide Synthase Type II, Phytochemicals
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