The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
What do we know about multicomponent reactions? Mechanisms and trends for the Biginelli, Hantzsch, Mannich, Passerini and Ugi MCRs
Open accessAbstract
The current manuscript describes the importance, mechanism propositions, evidence and controversies associated with multicomponent reactions (MCRs). The following multicomponent reactions are presented and critically evaluated: the Biginelli, Hantzsch, Mannich, Passerini and Ugi reactions. The aim of this review is to highlight what we already know about the mechanisms associated with these MCRs and the evidence supporting the proposed reaction pathways. Controversies and prospects are also discussed herein.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Recent Developments in Isocyanide Based Multicomponent Reactions in Applied Chemistry
Dömling, A. (2006) · Chemical Reviews · doi:10.1021/cr0505728 · Cited by 4,106
Multicomponent Reactions with Isocyanides
Dömling, A., & Ugi, I. (2000) · Angewandte Chemie · doi:10.1002/1521-3773(20000915)39:18<3168::aid-anie3168>3.0.co;2-u · Cited by 4,077
Chemistry and Biology Of Multicomponent Reactions
Dömling, A., Wang, W., & Wang, K. (2012) · Chemical Reviews · doi:10.1021/cr100233r · Cited by 2,547
Biologically active dihydropyrimidones of the Biginelli-type — a literature survey
Kappe, C. O. (2000) · European Journal of Medicinal Chemistry · doi:10.1016/s0223-5234(00)01189-2 · Cited by 1,352
Multicomponent reactions: advanced tools for sustainable organic synthesis
Cioc, R. C., Ruijter, E., & Orru, R. V. A. (2014) · Green Chem. · doi:10.1039/c4gc00013g · Cited by 1,339
100 years of the biginelli dihydropyrimidine synthesis
Oliver Kappe, C. (1993) · Tetrahedron · doi:10.1016/s0040-4020(01)87971-0 · Cited by 1,228
Recent applications of multicomponent reactions in medicinal chemistry
Slobbe, P., Ruijter, E., & Orru, R. V. A. (2012) · MedChemComm · doi:10.1039/c2md20089a · Cited by 484
Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics
Koopmanschap, G., Ruijter, E., & Orru, R. V. (2014) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.10.50 · Cited by 256
de Souza, R. O. M. A., da Penha, E. T., Milagre, H. M. S., et al. (2009) · Chemistry - A European Journal · doi:10.1002/chem.200900470 · Cited by 139
Ramos, L. M., Guido, B. C., Nobrega, C. C., Corrêa, J. R., da Silva, R. G., de Oliveira, H. C. B., Gomes, A. F., Gozzo, F. C., & Neto, B. A. D. (2013) · Chemistry - A European Journal · doi:10.1002/chem.201204314 · Cited by 133
Self-citation
Cited by
Liu, P., Hao, J.-W., Mo, L.-P., & Zhang, Z.-H. (2015) · RSC Advances · doi:10.1039/c5ra05746a · Cited by 663
Organic Reactions in Microdroplets: Reaction Acceleration Revealed by Mass Spectrometry
Yan, X., Bain, R. M., & Cooks, R. G. (2016) · Angewandte Chemie International Edition · doi:10.1002/anie.201602270 · Cited by 583
Green Chemistry in the Synthesis of Pharmaceuticals
Kar, S., Sanderson, H., Roy, K., Benfenati, E., & Leszczynski, J. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00631 · Cited by 566
Metadata
- Authors
- Alvim, H. G. O., da Silva Júnior, E. N., & Neto, B. A. D.
- Venue
- RSC Adv.
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2014-10-09
- Volume
- 4
- Issue
- 97
- Pages
- 54282-54299
- ISSN
- 2046-2069 (ISSN-L)
- OpenAlex
- W2083904809
- Cited by
- 261
- References
- 19
- FWCI
- 8.96
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: What do we know about multicomponent reactions? Mechanisms and trends for the Biginelli, Hantzsch, Mannich, Passerini and Ugi MCRs. https://app.cochat.ai/papers/10.1039/c4ra10651b
- The paper
- Alvim, H. G. O., da Silva Júnior, E. N., & Neto, B. A. D. (2014). What do we know about multicomponent reactions? Mechanisms and trends for the Biginelli, Hantzsch, Mannich, Passerini and Ugi MCRs. RSC Adv. https://doi.org/10.1039/c4ra10651b
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
