The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Recent applications of multicomponent reactions in medicinal chemistry
Abstract
Multicomponent reactions are flexible reactions for the rapid generation of complex molecules with often biologically relevant scaffold structures. Combined with the ease of parallelization and the exploratory power with regard to chemical space, multicomponent reactions have attracted significant attention from the medicinal chemistry community. In this Review, we present an overview of recent literature concerning this topic to provide insight into the applications of multicomponent reactions in this field.
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Citations
Cites
The protein kinase complement of the human genome
Manning, G., Whyte, D. B., Martinez, R., Hunter, T., & Sudarsanam, S. (2002) · Science · doi:10.1126/science.1075762 · Cited by 8,145
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661
Multicomponent Reactions with Isocyanides
Dömling, A., & Ugi, I. (2000) · Angewandte Chemie · doi:10.1002/1521-3773(20000915)39:18<3168::aid-anie3168>3.0.co;2-u · Cited by 4,077
Targeting multidrug resistance in cancer
Szakács, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C., & Gottesman, M. M. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1984 · Cited by 3,609
Natural products as sources of new drugs over the period 1981–2002
Newman, D. J., Cragg, G. M., & Snader, K. M. (2003) · Journal of Natural Products · doi:10.1021/np030096l · Cited by 3,082
Targeting cancer with small molecule kinase inhibitors
Zhang, J., Yang, P. L., & Gray, N. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2559 · Cited by 2,576
The evolving role of natural products in drug discovery
Koehn, F. E., & Carter, G. T. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1657 · Cited by 2,572
Chemistry and Biology Of Multicomponent Reactions
Dömling, A., Wang, W., & Wang, K. (2012) · Chemical Reviews · doi:10.1021/cr100233r · Cited by 2,547
Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain
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EGFR Antagonists in Cancer Treatment
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Cited by
Alvim, H. G. O., da Silva Júnior, E. N., & Neto, B. A. D. (2014) · RSC Adv. · doi:10.1039/c4ra10651b · Cited by 261
Metadata
- Authors
- Slobbe, P., Ruijter, E., & Orru, R. V. A.
- Venue
- MedChemComm
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 3
- Issue
- 10
- Pages
- 1189
- ISSN
- 2040-2503 (ISSN-L)
- 2040-2511
- OpenAlex
- W2148759018
- Cited by
- 484
- References
- 70
- FWCI
- 13.85
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
