Fish oil ameliorates trimethylamine N-oxide-exacerbated glucose intolerance in high-fat diet-fed mice
Abstract
Dietary fish oil could ameliorate trimethylamine N -oxide (TMAO)-induced impaired glucose tolerance in HFD-fed mice.
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High fat or Western-like diets increase plasma TMAO levels.
“Furthermore, high fat diets or Western-like diets increase plasma TMAO levels [8,34,35,36,37,38,39]”
From Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target (2018) · cites this paper as [36]
TMAO content correlates with high salinity and deep, cold environments.
“First, TMAO content correlates with high salinity and deep, cold environments161,162.”
From Dietary metabolism, the gut microbiome, and heart failure (2019) · cites this paper as [161]
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References 48 · Cited by 60
- Authors
- Gao, X., Xu, J., Jiang, C., Zhang, Y., Xue, Y., Li, Z., Wang, J., Xue, C., & Wang, Y.
- Affiliations
- Ocean University of China (CN)
- Corresponding author
- Xue, Changhu
- Wang, Yuming
- Venue
- Food & Function
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2015
- Volume
- 6
- Issue
- 4
- Pages
- 1117-1125
- ISSN
- 2042-6496 (ISSN-L)
- 2042-650X
- OpenAlex
- W2078059156
- Cited by
- 60
- References
- 48
- Citations by year
- 2025: 8 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 13 · 2020: 8 · 2019: 6 · 2018: 5 · 2017: 1 · 2016: 6
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food & Function (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China
- Program for New Century Excellent Talents in University
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- fish oil, trimethylamine N-oxide, impaired glucose tolerance, high-fat diet, insulin resistance, insulin signaling, adipose tissue inflammation, gluconeogenesis, glycogen synthesis, glucose transport, seafood
- MeSH terms
- Adipose Tissue, Animals, Blood Glucose, Dietary Fats, Fish Oils, Glucose Tolerance Test, Inflammation, Insulin, Cholesterol, HDL, Cholesterol, LDL, Male, Methylamines, Mice, Inbred C57BL, Triglycerides, Tumor Necrosis Factor-alpha, Signal Transduction, Interleukin-6, Interleukin-10, Glucose Intolerance, Chemokine CCL2, Interleukin-18, Mice, Adiponectin, Interleukin-1beta, Diet, High-Fat
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