The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
In situ deposition of a personalized nanofibrous dressing via a handy electrospinning device for skin wound care
Abstract
Current strategies for wound care provide limited relief to millions of patients who suffer from burns, chronic skin ulcers or surgical-related wounds. The goal of this work is to develop an in situ deposition of a personalized nanofibrous dressing via a handy electrospinning (e-spinning) device and evaluate its properties related to skin wound care. MCM-41 type mesoporous silica nanoparticles decorated with silver nanoparticles (Ag-MSNs) were prepared by a facile and environmentally friendly approach, which possessed long-term antibacterial activity and low cytotoxicity. Poly-ε-caprolactone (PCL) incorporated with Ag-MSNs was successfully electrospun (e-spun) into nanofibrous membranes. These in situ e-spun nanofibrous membranes allowed the continuous release of Ag ions and showed broad-spectrum antimicrobial activity against two common types of pathogens, Staphylococcus aureus and Escherichia coli. In addition, the in vivo studies revealed that these antibacterial nanofibrous membranes could reduce the inflammatory response and accelerate wound healing in Wistar rats. The above results strongly demonstrate that such patient-specific dressings could be broadly applied in emergency medical transport, hospitals, clinics and at the patients' home in the near future.
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Citations
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Applications of Polymer Nanofibers in Biomedicine and Biotechnology
Venugopal, J., & Ramakrishna, S. (2005) · Applied Biochemistry and Biotechnology · doi:10.1385/abab:125:3:147 · Cited by 370
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Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy
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Metadata
- Authors
- Dong, R.-H., Jia, Y.-X., Qin, C.-C., Zhan, L., Yan, X., Cui, L., Zhou, Y., Jiang, X., & Long, Y.-Z.
- Venue
- Nanoscale
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 8
- Issue
- 6
- Pages
- 3482-3488
- ISSN
- 2040-3364 (ISSN-L)
- 2040-3372
- OpenAlex
- W2236998776
- Cited by
- 174
- References
- 1
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: In situ deposition of a personalized nanofibrous dressing via a handy electrospinning device for skin wound care. https://app.cochat.ai/papers/10.1039/c5nr08367b
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- Dong, R.-H., Jia, Y.-X., Qin, C.-C., Zhan, L., Yan, X., Cui, L., Zhou, Y., Jiang, X., & Long, Y.-Z. (2016). In situ deposition of a personalized nanofibrous dressing via a handy electrospinning device for skin wound care. Nanoscale. https://doi.org/10.1039/c5nr08367b
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