Extending pharmacological dose-response curves for salsalate with natural deep eutectic solvents
Open accessAbstract
Natural deep eutectic solvents (NADES) are recently developed green solvents that are attractive for their great solubilising power and intrinsic lack of toxicity.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dissolution of salsalate in NADES allowed in vitro evaluation of its bioactivity.
“Additionally, formulation of resveratrol with NADES increased its matrix metalloproteinase-9 (MMP-9) inhibition activity (Shamseddin et al. 2017), while dissolution of salsalate in NADES allowed in vitro evaluation of its bioactivity (Rozema et al. 2015).”
From The perspectives of natural deep eutectic solvents in agri-food sector (2020) · cites this paper as Rozema et al. 2015
DESs can be a promising vehicle for poorly soluble compounds for preclinical studies, broadening the concentration range tested in dose-response curves.
“Thus, DESs can be a promising vehicle for poorly soluble compounds for preclinical studies, increasing the range of tested concentrations in doseeresponse curves.”
From Green solvents from ionic liquids and deep eutectic solvents to natural deep eutectic solvents (2018) · cites this paper as [82]
A 1,2-propanediol-choline chloride-water combination increased salsalate solubility in T37i cell culture medium, allowing a full dose-response curve.
“Rozema et al. [82] found that a combination of 1,2-propanediolecholine chlorideewater increased the solubility of salsalate in cell culture medium (T37i) allowing the assay of a full doseeresponse curve.”
From Green solvents from ionic liquids and deep eutectic solvents to natural deep eutectic solvents (2018) · cites this paper as [82]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 12 · Cited by 22
Research works printed but not linked: 10
- Y. Dai, J. van Spronsen, G. J. Witkamp, R. Verpoorte and Y. H. Choi, Anal. Chim. Acta, 2013, 766, 61-68.
- R. Ferraz, L. C. Branco, C. Prudêncio, J. P. Noronha and Z. Petrovski, ChemMedChem, 2011, 6, 975-985.
- K. K. Wu, Circulation, 2000, 102, 2022-2023.
- G. G. Duthie and A. D. Wood, Food Funct., 2011, 2, 515-520.
- A. B. Goldne, R. Silver, W. Aldhahi, D. Cai, E. Tatro, J. Lee and S. E. Shoelson, Clin. Transl. Sci., 2008, 1, 36-43.
- A. D. van Dam, K. J. Nahon, S. Kooijman, S. M. van den Berg, A. A. Kanhai, T. Kikuchi, M. M. Heemskerk, V. van Harmelen, M. Lombès, A. M. van den Hoek, M. P. J. de Winther, E. Lutgens, B. Guigas, P. C. N. Rensen and M. R. Boon, Diabetes, 2015, 64, 1544-1554.
- D. Estes and K. Kaplan, Arthritis Rheum., 1980, 23, 1303- 1307.
- H. Mielants, E. M. Veys, G. Verbruggen and K. Schelstraete, Scand. J. Rheumatol., 1981, 10, 169-173.
- A. Jakobsson, J. A. Jörgensen and A. Jacobsson, Am. J. Physiol.: Endocrinol. Metab., 2005, 289, E517-E526.
- V. Peirce, S. Carobbio and A. Vidal-Puig, Nature, 2014, 510, 76-83.
- Authors
- Rozema, E., van Dam, A. D., Sips, H. C. M., Verpoorte, R., Meijer, O. C., Kooijman, S., & Choi, Y. H.
- Affiliations
- Leiden University (NL)
- Department of Medicine
- Leiden University Medical Center (NL)
- Corresponding author
- Kooijman, S.
- Choi, Y. H.
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2015
- Volume
- 5
- Issue
- 75
- Pages
- 61398-61401
- ISSN
- 2046-2069 (ISSN-L)
- OpenAlex
- W1792053276
- Cited by
- 22
- References
- 12
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 2 · 2016: 2
- FWCI
- 0.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- RSC Advances (publishedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (711.012.010)
- Topics
- Physical Sciences › Chemical Engineering › Catalysis › Ionic liquids properties and applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Physical Sciences › Chemistry › Analytical Chemistry › Analytical Methods in Pharmaceuticals
- Keywords
- salsalate, natural deep eutectic solvents, dose-response curves, drug solubilization, green solvents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
