Bioabsorbable cellulose composites prepared by an improved mineral-binding process for bone defect repair
Abstract
Bioabsorbable bacterial cellulose composites were prepared separately by immersing bacterial cellulose (BC) in different simulated body fluids (SBF) followed by incorporating cellulase enzymes into BC. The biomineralization of BC in SBF has been intensively documented and generally involves a tedious preparation. This study revealed an improved approach to disperse hydroxyapatite (HA) nanopowder to a saturated concentration (1.0×) of SBF, which was able to enhance the total amount of calcium phosphates (CPs) bound to BC composites. Such a simplified approach could be used to replace oversaturated concentration (1.5×) of SBF to prepare BC/CPs composites and achieve equal or even better material properties. The incorporation of cellulosic enzymes into BC/CPs composites verified the bioabsorption of BC where composites were able to achieve an in vitro bulk biodegradation with a yield of 96% glucose released. Cell culture of mouse osteoblasts also demonstrated the good biocompatibility of the BC/CPs composites prepared by using the simplified approach. This enzyme-incorporating BC/CPs composites studied show promise as bioabsorbable carriers delivering CPs for bone defect repair.
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Under the assistance of a polydopamine coating layer, hydroxyapatite-coated biosubstitute surfaces such as titanium alloy and Ti6Al4V can immobilize active biomolecules such as BMP-2.
“In addition, under the assistance of PDA coating layer, the HA coated biosubstitute surface (e.g., titanium alloy, Ti6Al4V) can immobilize some active biomolecules such as BMP-2, and these immobilized biomolecules can be uniformly distributed on the surface and exhibit a sustainable release profile once in a real bone repair environment [70].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [70]
Immobilized biomolecules on hydroxyapatite/polydopamine-coated biosubstitute surfaces are uniformly distributed and exhibit a sustainable release profile in a real bone repair environment.
“these immobilized biomolecules can be uniformly distributed on the surface and exhibit a sustainable release profile once in a real bone repair environment [70].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [70]
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Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery
Janmohammadi, M., Nazemi, Z., Salehi, A. O. M., Seyfoori, A., John, J. V., Nourbakhsh, M. S., & Akbari, M. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.05.018 · Cited by 323 · see citing works
Polydopamine-Assisted Surface Modification for Bone Biosubstitutes
Huang, S., Liang, N., Hu, Y., Zhou, X., & Abidi, N. (2016) · BioMed Research International · doi:10.1155/2016/2389895 · Cited by 97 · see citing works
“The capability of bone biosubstitute inducing the mineralization containing the nucleation of calciumand the crystallization of nano-Hap in a real wound environment is an important index to evaluate the effectiveness of bone repair [69].”
BackgroundSelf-citation
- Authors
- Hu, Y., Zhu, Y., Zhou, X., Ruan, C., Pan, H., & Catchmark, J. M.
- Affiliations
- Pennsylvania State University (US)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Catchmark, Jeffrey M.
- Venue
- Journal of Materials Chemistry B
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 4
- Issue
- 7
- Pages
- 1235-1246
- ISSN
- 2050-750X (ISSN-L)
- 2050-7518
- OpenAlex
- W2230131753
- Cited by
- 56
- References
- 0
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 12 · 2018: 5 · 2017: 6 · 2016: 5
- FWCI
- 4.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Materials Chemistry B (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31570967)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Advanced Cellulose Research Studies
- Physical Sciences › Environmental Science › Environmental Engineering › Microbial Applications in Construction Materials
- Keywords
- bacterial cellulose, hydroxyapatite, calcium phosphate, simulated body fluid, biomineralization, cellulase, bone defect repair, biodegradation, osteoblast biocompatibility, drug carriers
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