Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin–MLL interaction
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A natural product-like compound was identified as a direct inhibitor of the menin–MLL interaction after in silico screening and structural modification.
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In leukemia, the MLL protein interacts with menin to promote oncogenic activity.
“For example, in leukemia, the mixed lineage leukemia (MLL) protein interacts with menin to promote oncogenic activity.”
From The design and development of covalent protein-protein interaction inhibitors for cancer treatment (2020) · cites this paper as [101]
Developing small molecule inhibitors to directly disrupt the MLL-menin interaction is a potential strategy for leukemia treatment.
“Therefore, developing small molecule inhibitors to directly disrupt the MLL-menin interaction is a potential strategy for leukemia treatment [100, 101].”
From The design and development of covalent protein-protein interaction inhibitors for cancer treatment (2020) · cites this paper as [101]
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- Authors
- Zhong, H.-J., Lee, B. R., Boyle, J. W., Wang, W., Ma, D.-L., Hong Chan, P. W., & Leung, C.-H.
- Affiliations
- University of Macau (MO)
- School of Chemistry
- Monash University (AU)
- Hong Kong Baptist University (HK)
- Corresponding author
- Ma, Dik-Lung
- Leung, Chung-Hang
- Venue
- Chemical Communications
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2016
- Volume
- 52
- Issue
- 34
- Pages
- 5788-5791
- ISSN
- 1359-7345 (ISSN-L)
- 1364-548X
- OpenAlex
- W2294856928
- Cited by
- 38
- References
- 24
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 10 · 2020: 3 · 2019: 5 · 2017: 5 · 2016: 3
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- green
- research.monash.edu
- Licence
- other-oa
- Locations
- Chemical Communications (publishedVersion)
- PubMed (publishedVersion)
- Monash University Research Portal (Monash University) (submittedVersion, other-oa)
- HKBU Institutional Repository (Hong Kong Baptist University) (submittedVersion)
- Funders
- Universidade de Macau (MRG023/LCH/2013/ICMS, MRG044/LCH/2015/ICMS, MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM)
- Health and Medical Research Fund (HMRF/14130522)
- Hong Kong Baptist University (FRG2/14-15/004)
- Science and Technology Development Fund (103/2012/A3)
- Research Grants Council, University Grants Committee (HKBU/201811, HKBU/201913, HKBU/204612)
- National Natural Science Foundation of China (21575121)
- Topics
- Physical Sciences › Computer Science › Computational Theory and Mathematics › Computational Drug Discovery Methods
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Keywords
- cytisine derivatives, structure-based drug design, protein-protein interaction inhibitors, natural product-like compounds, structure-activity optimization, Mi-2
- MeSH terms
- Quinolizidine Alkaloids, Alkaloids, Antineoplastic Agents, Azocines, Humans, Models, Molecular, Protein Binding, Histone-Lysine N-Methyltransferase, Proto-Oncogene Proteins, Quinolizines, Structure-Activity Relationship, Myeloid-Lymphoid Leukemia Protein, Hep G2 Cells
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