The osteoimmunomodulatory property of a barrier collagen membrane and its manipulation via coating nanometer-sized bioactive glass to improve guided bone regeneration
Abstract
A barrier membrane is a major component of guided bone regeneration (GBR), which is traditionally viewed as a physical barrier. Due to its "foreign body" nature, the implantation of a barrier membrane would inevitably modulate immune response and subsequently affect bone dynamics, which has long been neglected. To bridge this knowledge gap, we investigated the osteoimmunomodulatory effects of barrier collagen membranes. It is found that barrier collagen membranes elicit significant effects on modulating the osteoimmune response of macrophages, by upregulating the expression of pro-inflammatory cytokines (TNFα, IL-1β, IL-6, and IL-18) and osteogenic factors (BMP2/6, WNT10b, OSM). The modulated-osteoimmune environment was beneficial for the osteogenic differentiation of BMSCs, due to the activation of BMP, canonical WNT/β-catenin, and OSM signalling pathways. The membrane-mediated osteoimmunomodulation was further modulated to show whether osteogenesis could be enhanced via manipulating the membrane-mediated osteoimmunomodulation. The membrane-mediated osteoimmune response was successfully tuned through coating the collagen membranes with nanometer-sized bioactive glass Ca2ZnSi2O7 by pulsed laser deposition, which is indicated from the change in the expression profile of inflammatory cytokines and the upregulated expression of osteogenic factors. The modulated osteoimmune environment enhanced the osteogenic differentiation of BMSCs, suggesting that collagen membranes with nanometer-sized Ca2ZnSi2O7 coating can be promising for GBR applications. These results collectively imply that barrier membranes are bioactive barriers with an osteoimmunomodulatory effect and not just physical barriers. New generation barrier membranes should be designed with a favourable osteoimmunomodulatory property.
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Synthetic polymers suffer from decreased mechanical strength, poor shape withholding, limited cell adhesion, and release of potentially toxic by-products.
“Synthetic polymers also suffer from limitations such as decreased mechanical strength, poor shape withholding, limited cell adhesion, the release of potentially toxic by-products, etc [9].”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [9]
Collagen scaffolds do not have enough strength for bone regeneration.
“Collagen scaffold does not have enough strength for bone regeneration [9]”
From Nano-hydroxyapatite/collagen composite as scaffold material for bone regeneration. (2023) · cites this paper as [9]
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References 43 · Cited by 92
- Authors
- Chen, Z., Chen, L., Liu, R., Lin, Y., Chen, S., Lu, S., Lin, Z., Chen, Z., Wu, C., & Xiao, Y.
- Affiliations
- Sun Yat-sen University (CN)
- Queensland University of Technology (AU)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Chen, Zhuofan
- Wu, Chengtie
- Xiao, Yin
- ORCID
- Venue
- Biomaterials Science
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 6
- Issue
- 5
- Pages
- 1007-1019
- ISSN
- 2047-4830 (ISSN-L)
- 2047-4849
- OpenAlex
- W2789127085
- Cited by
- 92
- References
- 43
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 14 · 2023: 13 · 2022: 16 · 2021: 10 · 2020: 10 · 2019: 7 · 2018: 6
- FWCI
- 10.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomaterials Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81701024, 31370963)
- Osteology Foundation (Young Researcher Grant 2015)
- Topics
- Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Health Sciences › Medicine › Urology › Periodontal Regeneration and Treatments
- Keywords
- guided bone regeneration, osteoimmunomodulation, macrophage response, inflammatory cytokines, osteogenic differentiation, bone marrow mesenchymal stem cells, BMP signaling, Wnt/β-catenin signaling, pulsed laser deposition, foreign body reaction
- MeSH terms
- Animals, Bone Marrow Cells, Bone Regeneration, Cell Line, Cells, Cultured, Collagen, Glass, Humans, Macrophages, Male, Membranes, Artificial, Osteoclasts, Osteogenesis, Cytokines, Rats, Wistar, Bone Morphogenetic Proteins, Coated Materials, Biocompatible, Guided Tissue Regeneration, Nanostructures, Wnt Proteins, Mice, Rats
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