Recent advances in spirocyclization of indole derivatives

Privileged scaffolds for library design and drug discovery

Welsch, M. E., Snyder, S. A., & Stockwell, B. R. (2010) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2010.02.018 · Cited by 1,509

Synthesis of Spirocyclic Indolenines

James, M. J., O'Brien, P., Taylor, R. J. K., & Unsworth, W. P. (2016) · Chemistry – A European Journal · doi:10.1002/chem.201503835 · Cited by 338

Exploring Chemical Space for Drug Discovery Using the Chemical Universe Database

Reymond, J.-L., & Awale, M. (2012) · ACS Chemical Neuroscience · doi:10.1021/cn3000422 · Cited by 326

Synthesis of Functionalized 3-Spiro[cyclopropa[a]pyrrolizine]- and 3-Spiro[3-azabicyclo[3.1.0]hexane]oxindoles from Cyclopropenes and Azomethine Ylides via [3 + 2]-Cycloaddition

Filatov, A. S., Knyazev, N. A., Molchanov, A. P., Panikorovskii, T. L., Kostikov, R. R., Геннадьевна, Л. А., Boitsov, V. M., & Stepakov, A. V. (2016) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.6b02505 · Cited by 95

Thiourea–Quaternary Ammonium Salt Catalyzed Asymmetric 1, 3-Dipolar Cycloaddition of Imino Esters To Construct Spiro[pyrrolidin-3,3′-oxindoles]

Zhang, J., Wang, H., Jin, Q., Zheng, C., Zhao, G., & Shang, Y. (2016) · Organic Letters · doi:10.1021/acs.orglett.6b02098 · Cited by 78

Asymmetric [3 + 2] Cycloaddition of 3-Amino Oxindole-Based Azomethine Ylides and α,β-Enones with Divergent Diastereocontrol on the Spiro[pyrrolidine-oxindoles]

Zhu, G., Wei, Q., Chen, H., Zhang, Y., Shen, W. F., Qü, J., & Wang, B. (2017) · Organic Letters · doi:10.1021/acs.orglett.7b00625 · Cited by 74

Silver-Nanoparticle-Catalyzed Dearomatization of Indoles toward 3-Spiroindolenines via a 5-exo-dig Spirocyclization

Schrӧder, F., Sharma, U. K., Mertens, M., Devred, F., Debecker, D. P., Luque, R., & der Eycken, E. V. V. (2016) · ACS Catalysis · doi:10.1021/acscatal.6b02443 · Cited by 58

Asymmetric Synthesis of 2′‐Trifluoromethylated Spiro‐pyrrolidine‐3,3′‐oxindoles via Squaramide‐Catalyzed Umpolung and 1,3‐Dipolar Cycloaddition

Su, J., Ma, Z., Li, X., Lin, L., Shen, Z., Yang, P., Li, Y., Wang, H., Yan, W., Wang, K., et al. (2016) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201600688 · Cited by 56

Chiral N‐Heterocyclic Carbene‐Catalyzed Asymmetric Michael–Intramolecular Aldol‐Lactonization Cascade for Enantioselective Construction of β‐Propiolactone‐Fused Spiro[cyclopentane‐oxindoles]

Zhang, J., Li, N., Yin, S., Sun, B., Fan, W., & Wang, X. (2017) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201601259 · Cited by 51

Asymmetric [3+2] cycloaddition of 3-amino oxindole-based azomethine ylides with α,β-ynones: a straightforward approach to spirooxindoles incorporating 2,5-dihydropyrroles and pyrroles

Zhu, G., Wu, S., Bao, X., Cui, L., Zhang, Y., Qü, J., Chen, H., & Wang, B. (2017) · Chemical Communications · doi:10.1039/c7cc01653k · Cited by 42

The First Enantioselective Organocatalytic Synthesis of 3‐Spiro‐α‐Alkylidene‐γ‐Butyrolactone Oxindoles

Cerisoli, L., Lombardo, M., Trombini, C., & Quintavalla, A. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201504157 · Cited by 40

Iron(III)‐Catalyzed Arylation of Spiro‐Epoxyoxindoles with Phenols/Naphthols towards the Synthesis of Spirocyclic Oxindoles

Luo, M., Yuan, R., Liu, X., Yu, L., & Wei, W. (2016) · Chemistry - A European Journal · doi:10.1002/chem.201601185 · Cited by 37

Reversal of Selectivity in C3-Allylation and Formal [3 + 2]-Cycloaddition of Spiro-epoxyoxindole: Unified Synthesis of Spiro-furanooxindole, (±)-N-Methylcoerulescine, (±)-Physovenine, and 3a-Allylhexahydropyrrolo[2,3-b]indole

Hajra, S., Roy, S., & Maity, S. (2017) · Organic Letters · doi:10.1021/acs.orglett.7b00420 · Cited by 37

Enantioselective Cascade Reaction of α‐Cyano Ketones and Isatylidene Malononitriles: Asymmetric Construction of Spiro[4H‐pyran‐oxindoles]

Xie, J., Xing, W., Sha, F., & Wu, X. (2016) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201600432 · Cited by 35

Assembly of Indolenines, 3-Amino Oxindoles, and Aldehydes into Indolenine-Substituted Spiro[pyrrolidin-2,3′-oxindoles] via 1,3-Dipolar Cycloaddition with Divergent Diastereoselectivities

Zhu, G., Liu, S., Wu, S., Peng, L., Qü, J., & Wang, B. (2017) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.7b00316 · Cited by 34

Leaching‐Free Supported Gold Nanoparticles Catalyzing Cycloisomerizations under Microflow Conditions

Schrӧder, F., Erdmann, N., Noël, T., Luque, R., & der Eycken, E. V. V. (2015) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201500628 · Cited by 31

The organocatalytic asymmetric Neber reaction for the enantioselective synthesis of spirooxindole 2H-azirines

Zhao, J., Yue, D., Zhang, X., Xu, X., & Yuan, W. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c6ob02220k · Cited by 29

Ambient temperature synthesis of spiro[indoline-3,2′-thiazolidinones] by a DBSA-catalyzed sequential reaction in water

Preetam, A., & Nath, M. (2016) · Tetrahedron Letters · doi:10.1016/j.tetlet.2016.02.079 · Cited by 26

Discovery of novel polycyclic spiro-fused carbocyclicoxindole-based anticancer agents

Zhang, L., Ren, W. T., Wang, X., Zhang, J., Liu, J., Zhao, L., & Zhang, X. (2016) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2016.12.021 · Cited by 25

Synthesis of Cyclobutane-Fused Angular Tetracyclic Spiroindolines via Visible-Light-Promoted Intramolecular Dearomatization of Indole Derivatives

Zhu, M., Zheng, C., Zhang, X., & You, S.-L. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b12965 · Cited by 298

Energy-Transfer-Enabled Dearomative Cycloaddition Reactions of Indoles/Pyrroles via Excited-State Aromatics

Zhu, M., Zhang, X., Zheng, C., & You, S.-L. (2022) · Accounts of Chemical Research · doi:10.1021/acs.accounts.2c00412 · Cited by 267