Ferritin nanocages loaded with gold ions induce oxidative stress and apoptosis in MCF-7 human breast cancer cells
Abstract
Two anticancer gold(iii) compounds, Au2phen and Auoxo4, were encapsulated within a ferritin nanocage. The gold-compound loaded proteins were characterized by UV-Vis spectroscopy, inductively coupled plasma mass spectrometry and circular dichroism. X-ray crystallography shows that the compounds degrade upon encapsulation and gold(i) ions bind Ft within the cage, close to the side chains of Cys126. The gold-encapsulated nanocarriers are cytotoxic to human cancer cells. Au(i)-loaded Ft, obtained upon the encapsulation of Au2phen within the cage, induces oxidative stress activation, which finally leads to apoptosis in MCF-7 cells.
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FT nanocages are used to encapsulate chemotherapeutic agents such as doxorubicin or gold ions to induce tumor cell death.
“FT nanocages are used to encapsulate chemotherapeutic agents such as doxorubicin [115] or gold ions to induce tumor cell death [116].”
From Iron as a central player and promising target in cancer progression (2019) · cites this paper as [116]
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- Authors
- Monti, D. M., Ferraro, G., Petruk, G., Maiore, L., Pane, F., Amoresano, A., Cinellu, M. A., & Merlino, A.
- Affiliations
- University of Naples Federico II (IT)
- University of Sassari (IT)
- Corresponding author
- Merlino, Antonello
- ORCID
- Venue
- Dalton Transactions
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 46
- Issue
- 44
- Pages
- 15354-15362
- ISSN
- 1477-9226 (ISSN-L)
- 1477-9234
- OpenAlex
- W2761075434
- Cited by
- 49
- References
- 45
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 7
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Dalton Transactions (publishedVersion)
- PubMed (publishedVersion)
- UnissResearch (Università degli Studi di Sassari) (submittedVersion)
- Topics
- Health Sciences › Medicine › Oncology › Metal complexes synthesis and properties
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Materials Science › Electronic, Optical and Magnetic Materials › Gold and Silver Nanoparticles Synthesis and Applications
- Keywords
- ferritin nanocages, gold(III) complexes, oxidative stress, apoptosis, MCF-7 cells, anticancer nanocarriers, cytotoxicity
- MeSH terms
- Antineoplastic Agents, Binding Sites, Ferritins, Gold, Humans, Ions, Molecular Conformation, Spectrophotometry, Apoptosis, Crystallography, X-Ray, Oxidative Stress, Nanostructures, Coordination Complexes, MCF-7 Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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