Integrated heart/cancer on a chip to reproduce the side effects of anti-cancer drugs in vitro
Abstract
Integrated Heart/Cancer on a Chip (iHCC) is a promising microfluidic platform that allows the culture of different cell types separately and application of closed-medium circulation to reproduce the side effects of doxorubicin on heart in vitro .
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Current GLA-MPSs are based on two approaches: the cell-culture insert in microtiter plates and microfluidic devices.
“The current GLA-MPSs are based on two approaches: the cell-culture insert in the microtiter plates 7,11 and microfluidic devices.12,13”
From Gut-liver-axis microphysiological system for studying cellular fluidic shear stress and inter-tissue interaction (2022) · cites this paper as [13]
Use of a microfluidic device allows control of perfusion flow in planar compartmentalized chambers and interconnection of two or more tissue cells via a microfluidic channel with an on-chip micropump.
“In contrast, the use of a microfluidic device allows the control of perfusion flow in the planar compartmentalized chambers and the interconnection of two or more tissue cells via a microfluidic channel with an on-chip micropump.12,13,16”
From Gut-liver-axis microphysiological system for studying cellular fluidic shear stress and inter-tissue interaction (2022) · cites this paper as [13]
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Drug Toxicity Evaluation Based on Organ-on-a-chip Technology: A Review
Cong, Y., Han, X., Wang, Y., Chen, Z., Lu, Y., Liu, T., Wu, Z., Jin, Y., Luo, Y., & Zhang, X. (2020) · Micromachines · doi:10.3390/mi11040381 · Cited by 140 · see citing works
Bridging the gap between tumor-on-chip and clinics: a systematic review of 15 years of studies
Bouquerel, C., Dubrova, A., Hofer, I., Phan, D. T. T., Bernheim, M., Ladaigue, S., Cavaniol, C., Maddalo, D., Cabel, L., Mechta-Grigoriou, F., et al. (2023) · Lab on a Chip · doi:10.1039/d3lc00531c · Cited by 58 · see citing works
Liver–heart on chip models for drug safety
Ferrari, E., & Rasponi, M. (2021) · APL Bioengineering · doi:10.1063/5.0048986 · Cited by 53 · see citing works
Yang, J., Hirai, Y., Imamura, S., Tsuchiya, T., Tabata, O., & Kamei, K.-I. (2022) · doi:10.1101/2022.01.31.478467 · Cited by 21 · see citing works
Self-citation
- Authors
- Kamei, K.-I., Kato, Y., Hirai, Y., Ito, S., Satoh, J., Oka, A., Tsuchiya, T., Chen, Y., & Tabata, O.
- Affiliations
- Institute for Integrated Cell-Material Sciences (WPI-iCeMS)
- Department of Micro Engineering
- Medical Research Support Center
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2017
- Volume
- 7
- Issue
- 58
- Pages
- 36777-36786
- ISSN
- 2046-2069
- Cited by
- 119
- References
- 2
- Language
- en
- Funders
- Japan Society for the Promotion of Science (16K14660, 24656502)
- Ministry of Education, Culture, Sports, Science, and Technology (World Premier International Research Centre Initia)
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