Collagen-based three-dimensional culture microenvironment promotes epithelial to mesenchymal transition and drug resistance of human ovarian cancer in vitro

Cancer Statistics, 2017.

Siegel, R. L., Miller, K. D., & Jemal, A. (2017) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21387 · Cited by 14,712 · see citing works

The basics of epithelial-mesenchymal transition

Kalluri, R., & Weinberg, R. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39104 · Cited by 10,196 · see citing works

Epithelial–mesenchymal transitions in tumour progression

Thiery, J. P. (2002) · Nature reviews. Cancer · doi:10.1038/nrc822 · Cited by 6,632 · see citing works

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.

Yang, J., & Weinberg, R. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.05.009 · Cited by 3,135 · see citing works

The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2

Park, S.-M., Gaur, A. B., Lengyel, E., & Peter, M. E. (2008) · Genes & Development · doi:10.1101/gad.1640608 · Cited by 2,272 · see citing works

Molecular requirements for epithelial–mesenchymal transition during tumor progression

Huber, M. A., Kraut, N., & Beug, H. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.001 · Cited by 1,813 · see citing works

Snail and Slug Mediate Radioresistance and Chemoresistance by Antagonizing p53-Mediated Apoptosis and Acquiring a Stem-Like Phenotype in Ovarian Cancer Cells

Kurrey, N. K., Jalgaonkar, S. P., Joglekar, A. V., Ghanate, A. D., Chaskar, P. D., Doiphode, R. Y., & Bapat, S. A. (2009) · Stem Cells · doi:10.1002/stem.154 · Cited by 655 · see citing works

EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancer

Haslehurst, A., Koti, M., Dharsee, M., Nuin, P. A. S., Evans, K., Geraci, J., Childs, T. J., Chen, J., Li, J., Weberpals, J. I., et al. (2012) · BMC Cancer · doi:10.1186/1471-2407-12-91 · Cited by 402 · see citing works

The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis

Zhang, K., Corsa, C. A. S., Ponik, S. M., Prior, J. L., Piwnica-Worms, D. R., Eliceiri, K. W., Keely, P. J., & Longmore, G. D. (2013) · Nature Cell Biology · doi:10.1038/ncb2743 · Cited by 393 · see citing works

Interstitial collagenases as markers of tumor progression.

Brinckerhoff, C., Rutter, J. L., & Benbow, U. (2000) · PubMed · Cited by 333 · see citing works

EMT and Stem Cell–Like Properties Associated with miR-205 and miR-200 Epigenetic Silencing Are Early Manifestations during Carcinogen-Induced Transformation of Human Lung Epithelial Cells

Tellez, C. S., Juri, D. E., Do, K., Bernauer, A. M., Thomas, C. L., Damiani, L. A., Tessema, M., Leng, S., & Belinsky, S. A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-3035 · Cited by 277 · see citing works

Integrin α5β1 facilitates cancer cell invasion through enhanced contractile forces

Mierke, C. T., Frey, B., Fellner, M., i, M. H., & Fabry, B. (2011) · Journal of Cell Science · doi:10.1242/jcs.071985 · Cited by 268 · see citing works

Collagen I Promotes Epithelial-to-Mesenchymal Transition in Lung Cancer Cells via Transforming Growth Factor–β Signaling

Shintani, Y., Maeda, M., Chaika, N. V., Johnson, K. R., & Wheelock, M. J. (2007) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2007-0071oc · Cited by 259 · see citing works

Modeling Ewing sarcoma tumors in vitro with 3D scaffolds

Fong, E. L. S., Lamhamedi-Cherradi, S.-E., Burdett, E., Ramamoorthy, V., Lazar, A. J., Kasper, F. K., Farach‐Carson, M. C., Vishwamitra, D., Demicco, E. G., Menegaz, B. A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221403110 · Cited by 238 · see citing works

Molecular and pathological signatures of epithelial–mesenchymal transitions at the cancer invasion front

Wever, O. D., Pauwels, P., Craene, B. D., Sabbah, M., Emami, S., Redeuilh, G., Gespach, C. P., Bracke, M., & Berx, G. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0464-1 · Cited by 229 · see citing works

Collagen I Promotes Metastasis in Pancreatic Cancer by Activating c-Jun NH2-Terminal Kinase 1 and Up-regulating N-Cadherin Expression

Shintani, Y., Hollingsworth, M. A., Wheelock, M. J., & Johnson, K. R. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-2322 · Cited by 221 · see citing works

Down-regulation of E-cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines.

Menke, A., Philippi, C., Vogelmann, R., Seidel, B., Lutz, M. P., Adler, G., & Wedlich, D. (2001) · PubMed · Cited by 196 · see citing works

Tumor cell invasiveness correlates with changes in integrin expression and localization

Macho‐Maschler, S., Wirl, G., Spring, H., Bredow, D. V., Sordat, I., Beug, H., & Ernst Reichmann, A. (2005) · Oncogene · doi:10.1038/sj.onc.1208423 · Cited by 190 · see citing works

Resistance to platinum-based chemotherapy is associated with epithelial to mesenchymal transition in epithelial ovarian cancer

Marchini, S., Fruscio, R., Clivio, L., Beltrame, L., Porcu, L., Nerini, I. F., Cavalieri, D., Chiorino, G., Cattoretti, G., Mangioni, C., et al. (2013) · European Journal of Cancer · doi:10.1016/j.ejca.2012.06.026 · Cited by 176 · see citing works

A 3D Fibrous Scaffold Inducing Tumoroids: A Platform for Anticancer Drug Development

Girard, Y., Wang, C., Ravi, S., Howell, M., Mallela, J. P., Alibrahim, M., Green, R. J., Hellermann, G., Mohapatra, S. S., & Mohapatra, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075345 · Cited by 134 · see citing works

The α2β1 integrin mediates the malignant phenotype on type I collagen in pancreatic cancer cell lines

Grzesiak, J. J., & Bouvet, M. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603088 · Cited by 119 · see citing works

Targeting epithelial-mesenchymal transition and cancer stem cells for chemoresistant ovarian cancer

Deng, J., Wang, L., Chen, H., Hao, J., Ni, J., Chang, L., Duan, W., Graham, P., & Li, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.9908 · Cited by 115 · see citing works

Collagen I but not Matrigel matrices provide an MMP-dependent barrier to ovarian cancer cell penetration

Sodek, K. L., Brown, T. J., & Ringuette, M. J. (2008) · BMC Cancer · doi:10.1186/1471-2407-8-223 · Cited by 111 · see citing works

miR-206 regulates cisplatin resistance and EMT in human lung adenocarcinoma cells partly by targeting MET

Chen, Q., Jiao, D., Wang, J., Hu, H., Tang, X., Chen, J., Mou, H., & Lu, W. (2016) · Oncotarget · doi:10.18632/oncotarget.8229 · Cited by 100 · see citing works

Composition of the extracellular matrix of the peritoneum

Witz, C. (2001) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(01)00122-8 · Cited by 96 · see citing works

Acquisition of epithelial–mesenchymal transition and cancer stem-like phenotypes within chitosan-hyaluronan membrane-derived 3D tumor spheroids

Huang, Y.-J., & Hsu, S. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2014.09.010 · Cited by 77 · see citing works

Proliferation and Differentiation of Mouse Embryonic Stem Cells in APA Microcapsule: A Model for Studying the Interaction between Stem Cells and Their Niche

Wang, X., Wang, W., Ma, J., et al. (2006) · Biotechnology Progress · doi:10.1021/bp050386n · Cited by 75 · see citing works

MiR-770-5p inhibits cisplatin chemoresistance in human ovarian cancer by targeting ERCC2

Zhao, H., Yu, X., Ding, Y., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10736 · Cited by 75 · see citing works

Expression of miR-136 is associated with the primary cisplatin resistance of human epithelial ovarian cancer

Zhao, H., LIU, S., Wang, G., WU, X., Ding, Y., Guo, G., Jiang, J., & Cui, S. (2014) · Oncology Reports · doi:10.3892/or.2014.3640 · Cited by 71 · see citing works

Expression of miR-224-5p is associated with the original cisplatin resistance of ovarian papillary serous carcinoma

Zhao, H., BI, T., Qu, Z., et al. (2014) · Oncology Reports · doi:10.3892/or.2014.3311 · Cited by 64 · see citing works

Effect of microRNA-206 on Cytoskeleton Remodelling by Downregulating Cdc42 in MDA-MB-231 Cells

Liu, H., Cao, Y., Ye, W., & Sun, Y. (2010) · Tumori Journal · doi:10.1177/030089161009600518 · Cited by 60 · see citing works

Motility-related actinin alpha-4 is associated with advanced and metastatic ovarian carcinoma

Barbolina, M. V., Adley, B. P., Kelly, D. L., et al. (2008) · Laboratory Investigation · doi:10.1038/labinvest.2008.25 · Cited by 58 · see citing works

Cancer early dissemination: cancerous epithelial-mesenchymal transdifferentiation and transforming growth factor signalling

Sabe, H. (2011) · The Journal of Biochemistry · doi:10.1093/jb/mvr044 · Cited by 58 · see citing works

Progressive ovarian carcinoma induces synthesis of type I and type III procollagens in the tumor tissue and peritoneal cavity.

Zhu, G., Risteli, J., Puistola, U., Kauppila, A., & Risteli, L. (1993) · PubMed · Cited by 52 · see citing works

Ovarian normal and tumor-associated fibroblasts retain in vivo stromal characteristics in a 3-D matrix-dependent manner

Quiros, R. M., Valianou, M., Kwon, Y., Brown, K. M., Godwin, A. K., & Cukierman, E. (2008) · Gynecologic Oncology · doi:10.1016/j.ygyno.2008.03.006 · Cited by 52 · see citing works

Tumor microenvironment and noncoding RNAs as co‐drivers of epithelial–mesenchymal transition and cancer metastasis

Alsibai, K. D., & Meseure, D. (2017) · Developmental Dynamics · doi:10.1002/dvdy.24548 · Cited by 51 · see citing works

Coordinated expression of integrin subunits, matrix metalloproteinases (MMP), angiogenic genes and Ets transcription factors in advanced-stage ovarian carcinoma: A possible activation pathway?

Davidson, B., Goldberg, I., Gotlieb, W. H., Kopolovic, J., Risberg, B. Å., Ben‐Baruch, G., & Reich, R. (2003) · Cancer and Metastasis Reviews · doi:10.1023/a:1022272204045 · Cited by 50 · see citing works

Chitosan-hyaluronan based 3D co-culture platform for studying the crosstalk of lung cancer cells and mesenchymal stem cells

Han, H., & Hsu, S. (2016) · Acta Biomaterialia · doi:10.1016/j.actbio.2016.06.014 · Cited by 45 · see citing works

Fibrillar Type I Collagen Matrices Enhance Metastasis/Invasion of Ovarian Epithelial Cancer Via β1 Integrin and PTEN Signals

Shen, Y., Shen, R., Ge, L., Zhu, Q., & Li, F. (2012) · International Journal of Gynecological Cancer · doi:10.1097/igc.0b013e318263ef34 · Cited by 38 · see citing works

Three-Dimensional Collagen Type I Matrix Up-Regulates Nuclear Isoforms of the Microtubule Associated Protein Tau Implicated in Resistance to Paclitaxel Therapy in Ovarian Carcinoma

Main, H. G., Yu, Y., Choi, J. J., Kajdacsy‐Balla, A., & Barbolina, M. V. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16023419 · Cited by 37 · see citing works

A novel 3D in vitro metastasis model elucidates differential invasive strategies during and after breaching basement membrane

Guzman, A., Alemany, V. S., Nguyen, Y. T.-K., Zhang, C. R., & Kaufman, L. J. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.11.014 · Cited by 37 · see citing works

Neoangiogenesis: A putative marker of malignancy in non-small-cell-lung-cancer (NSCLC) development

Fontanini, G., Vignati, S., Bigini, D., Lucchi, M., Mussi, A., Basolo, F., Angeletti, C. A., & Bevilacqua, G. (1996) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19960904)67:5 · Cited by 34 · see citing works

Composition of the Extracellular Matrix of the Peritoneum

Witz, C. A., Montoya-Rodriguez, I. A., Cho, S., Centonze, V. E., Bonewald, L. F., & Schenken, R. S. (2001) · Journal of the Society for Gynecologic Investigation · doi:10.1177/107155760100800508 · Cited by 24 · see citing works

Isolation of Mammary Epithelial Cells from Three-dimensional Mixed-cell Spheroid Co-culture

Xu, K., & Buchsbaum, R. J. (2012) · Journal of Visualized Experiments · doi:10.3791/3760 · Cited by 16 · see citing works

Inhibition of IGF-1-Mediated Cellular Migration and Invasion by Migracin A in Ovarian Clear Cell Carcinoma Cells

Ukaji, T., Lin, Y., Banno, K., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137663 · Cited by 12 · see citing works

Three-dimensional modelling of ovarian cancer: from cell lines to organoids for discovery and personalized medicine

Yee, C., Dickson, K.-A., Muntasir, M. N., Ma, Y., & Marsh, D. J. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.836984 · Cited by 66 · see citing works

An omentum-inspired 3d peg hydrogel for identifying ecm-drivers of drug resistant ovarian cancer

Brooks, E. A., Gencoglu, M. F., Corbett, D. C., Stevens, K. R., & Peyton, S. R. (2019) · APL Bioengineering · doi:10.1063/1.5091713 · Cited by 51 · see citing works

[Immunofluorescence study of intermediate filament protein vimentin of CP-activated macrophages].

Su, Y. X. (1990) · PubMed

TGF-β1 regulates invasion and migration of human bladder cancer cells T24 through epithelial mesenchymal transition

Wu, G., Yin, Y., & Bai, P. (2017) · Biomedical Research-tokyo · Cited by 1 · see citing works

Fra‐1 regulates vimentin during Ha‐RAS‐induced epithelial mesenchymal transition in human colon carcinoma cells

Andreolas, C., Καλογεροπούλου, Μ., Voulgari, A., et al. (2007) · International Journal of Cancer · doi:10.1002/ijc.23309 · Cited by 73 · see citing works

Effects of over-expression of macrophage migration inhibitory factor on the epithelial-mesenchymal transition in cervical cancer cells SiHa

Shi, X., & Liu, W. (2014) · 肿瘤研究与临床 · doi:10.3760/cma.j.issn.1006-9801.2014.11.004

The expression of epithelial mesenchymal transition related factors in human colorectal cancer cell lines

Kim, M. J., Cho, Y. B., Chun, H.-K., et al. (2013) · Korean Journal of Clinical Oncology · doi:10.14216/kjco.13030 · Cited by 3 · see citing works