Reversible generation of coacervate droplets in an enzymatic network
Open accessAbstract
Here we develop ATP-based coacervate droplets as artificial membraneless organelles that can be fully controlled by two cooperating enzymes.
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The enzymatic reaction is fast enough to overcome passive coarsening and slow enough to avoid spinodal decomposition.
“We can thus ensure that the reaction is fast enough to overcome passive coarsening and slow enough to avoid spinodal decomposition19,20.”
From Active coacervate droplets are protocells that grow and resist Ostwald ripening (2021) · cites this paper as [19]
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Prebiotic Peptides: Molecular Hubs in the Origin of Life
Frenkel-Pinter, M., Samanta, M., Ashkenasy, G., & Leman, L. J. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.9b00664 · Cited by 354 · see citing works
Active coacervate droplets are protocells that grow and resist Ostwald ripening
Nakashima, K. K., van Haren, M. H. I., André, A. A. M., Robu, I., & Spruijt, E. (2021) · Nature Communications · doi:10.1038/s41467-021-24111-x · Cited by 209 · see citing works
Self-citationChemical-mediated translocation in protocell-based microactuators
Gao, N., Li, M., Tian, L., Patil, A. J., Pavan Kumar, B. V. V. S., & Mann, S. (2021) · Nature Chemistry · doi:10.1038/s41557-021-00728-9 · Cited by 60 · see citing works
Complex coacervates as artificial membraneless organelles and protocells
Deng, N.-N. (2020) · Biomicrofluidics · doi:10.1063/5.0023678 · Cited by 40 · see citing works
- Authors
- Nakashima, K. K., Baaij, J. F., & Spruijt, E.
- Affiliations
- Radboud University Nijmegen (NL)
- Corresponding author
- Spruijt, Evan
- Venue
- Soft Matter
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2018
- Volume
- 14
- Issue
- 3
- Pages
- 361-367
- ISSN
- 1744-683X (ISSN-L)
- 1744-6848
- OpenAlex
- W2772280491
- Cited by
- 194
- References
- 0
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 26 · 2023: 31 · 2022: 25 · 2021: 25 · 2020: 29 · 2019: 17 · 2018: 8
- FWCI
- 5.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Soft Matter (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (project number 016.162.010)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Supramolecular Self-Assembly in Materials
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- coacervate droplets, phosphoenolpyruvate, glucose, enzyme kinetics, reaction network modeling, droplet nucleation, coarsening, droplet dissolution
- MeSH terms
- Adenosine Diphosphate, Adenosine Triphosphate, Enzymes, Organelles, Static Electricity, Hydrodynamics
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